UCLA CTSI is an academic-community partnership to accelerate scientific discoveries and clinical breakthroughs to improve health and health care in Los Angeles, the most populous county, and among the most diverse, in the United States. Its mission is to create a borderless clinical and translational research institute that brings UCLA resources and innovations to bear on the greatest health needs of Los Angeles. It is one of 62 CTSAs supported by the National Center for Advancing Translational Sciences (NCATS) at NIH.
The information is very informative and promising, the presenter should yield to someone else. He is too fast and careless. He also needs to stop moving the pointer, slow down, and change the tone. Pretend that you care about your content. He seems bothered. Terrible presentation, but vital information.
🎯 Key Takeaways for quick navigation: 00:50 *🧬 Common complex diseases like Alzheimer's, Parkinson's, diabetes, and obesity remain poorly understood despite vast research funding.* 02:41 *📚 Thomas Kuhn's idea of paradigms in science highlights the importance of initial conceptual frameworks in shaping scientific understanding.* 05:14 *⚡️ Energy, particularly mitochondrial function, plays a crucial role in health and disease beyond traditional anatomical perspectives.* 07:17 *🔬 Bioenergetic dysfunction is proposed as the root cause of common complex diseases, shifting focus from anatomy to energy metabolism.* 16:04 *💡 Mitochondrial DNA inheritance from maternal lineage ensures conservation of energy circuitry, vital for cellular function.* 21:20 *🧠 Different tissues have varying reliance on mitochondrial energy, leading to tissue-specific symptoms in mitochondrial dysfunction.* 22:30 *🔬 Mitochondrial bioenergetics play a crucial role in regulating energy, reactive oxygen species, and cellular function, affecting various aspects of health.* 23:13 *🧬 Inhibited mitochondrial function can lead to energy deficits, DNA replication errors, and age-related decline, potentially contributing to the onset and progression of common diseases.* 24:22 *⚕️ Certain mitochondrial mutations can result in diverse phenotypes, ranging from neurological symptoms to metabolic disorders, illustrating the complexity of mitochondrial genetics.* 26:38 *🧪 Transcriptomic analysis reveals distinct gene expression patterns in response to different levels of mitochondrial mutations, indicating a fine-tuned regulatory mechanism.* 27:18 *🔄 Nuclear-cytoplasmic interactions are essential for understanding mitochondrial pathology and disease manifestation.* 30:44 *🧠 Mitochondrial mutations can have varying effects on phenotype, influencing neurological disorders, diabetes, and cardiomyopathy, highlighting the importance of mitochondrial genetics in disease.* 35:19 *🌍 Geographic distribution of mitochondrial DNA variants suggests adaptation to environmental factors, such as altitude and climate, influencing disease susceptibility.* 39:35 *🔄 Mitochondrial mutations may exhibit context-dependent effects, with variants showing both beneficial and detrimental outcomes depending on genetic backgrounds and environmental factors.* 44:52 *🏃 Mutant mice with mitochondrial mutations exhibit collapse during exercise, indicating a progressive mitochondrial dysfunction.* 46:14 *🍔 Mutant mice with high mitochondrial levels resist high-fat diets and display insulin sensitivity, contrary to expectations.* 47:08 *🧠 Mice with mitochondrial mutations exhibit subtle behavioral changes, indicating potential links between energetics and personality traits.* 50:11 *⚡ Partial mitochondrial defects can affect long-range migration of neurons, potentially contributing to neurological disorders like schizophrenia or autism.* 53:07 *🔬 Research suggests mitochondrial bioenergetics could bridge Western and Eastern medical approaches, potentially impacting treatments like herbal medicine and acupuncture.* 57:19 *🧬 Mitochondria serve as environmental sensors, communicating with the nucleus to maintain homeostasis; dysfunction leads to bioenergetic decline, disease, and aging.* Made with HARPA AI
He is our guru ( bioquantum hackers) too bad he has no time to go sub atomic. I have. Thanks to a career in solid state physics, semiconductors and biohackin’ and finally the disasterous health outcomes now over turned. Only if one gets very sick, will they become motivated to connect the dots of pharma history, funding of research, biology, quantum effects and etiology of mitochondrion dysfunction👏🏻
Kids really need good fresh food that's not processed. A lot of health problems come from the high sugar and that's in shelf stable food. Poor people are often obese due to highly processed food.
Can anyone brilliant provide time stamps and summary .., I see this is more more true it’s about the energetics and I really think NAD creatine ubiquinol, magnesium and carnitine can be very helpful
I wonder where she gets her money from? Conflicts of interest anyone? Low carb or carnivore diet would have this subject feeling better than ever within a few months, guaranteed. But that doesn’t make as much money for docs and Big Pharma now does it? Doctors are just drug dealers and procedure pushers. They have no ability and most, no desire to push for actual health. Why do you think everyone is so sick?
Quite simply everyone, there is a biological system already in place...therefore God-engineered, logistically...doing all of the classic adaptations. What is this biological system? It's called the epigenome. It's actions is called epigenetics. This includes adaptations seen in Darwin Finches without any natural selection of DNA mutations. Instead it's modifications by chemical tagging turning genes up and down or on and off for different structures such as new beaks for new diets. This is FAST...doing its job in just 2 generations, not millions of years by 'evolution'. Evolution is a scam folks. We are an intelligent design by Jesus Christ. This means he offers a free gift of eternal life just for believing in it and believing he resurrected. Take the free gift today!!!
You fail to mention that a lot of the people with "neuropsychiatric disorders" don't see them as disorders and don't want a cure. The definition of mental "disorders" and "cures" can be as much due to societal, especially neoliberalism capitalist values as it has to do with science.
The only two things I find missing in this lecture are one a creationist perspective and two the effects that the introduction of vaccines have had on this system. I realize this perspective is not popular but it is real. I appreciate the lecture and I believe there plenty of nuggets in here. The logic makes sense but if we only presume that evolution is fact we can become mislead. I believe that mutations have come from vaccines because many of these diseases we did not have prior to there introduction into the population along with EMFs and non native light.
We know why you don’t find the most basic of answers to medical issues plaguing Americans. Because medicine isn’t about curing illness it’s about producing synthetic medication’s. Dad user does more damage in the end than it does. Good paradigm. Western medicine was co-opted by the Rockefellers in the 20s, forcing out all holistic doctors, many of which had recent breakthroughs in disease and in treating and curing those diseases. Many of these doctors were put out of business or worse. Rockefeller being the oil man that he was, then put as the objective for Western medicine, to use oil based synthetic medication’s to treat American disease. But let’s be clear not to curate, to manage symptoms things like chemotherapy, that sure, kills cancer, along with your mitochondria and damages, various organs, etc. that should you survive it, decreases your lifespan dramatically, but chemotherapy isn’t just for cancer anymore! No, chemotherapy drugs have been used to treat the mythological AIDS virus And is even being used unbeknownst to the majority of Americans, as an antibiotic. One of the most prescribed antibiotics. - Cipro. So if you’ve been prescribed Cipro say for a urinary tract infection or a sinus infection, congratulations, you’ve just completed your first, second, third, fourth… Round of chemo therapy and if you think your body has a suffered consequences, think again. It damages your mitochondria and causes all kinds of diseases, like diabetes, high blood pressure, and a long list of other diseases that Western medicine just chocks up to bad diet and aging. Face it people, we have all been taken for a big ride.
Having just watched another mitochondria talk (Chandel), it seems to me that autoimmune disease stems from lack of energy production in regulatory T cells. They showed that if you take out the mitochondria, the T cells survive and multiply just fine, but they stop taking any actions based on antigens, which resulted in autoimmunity for example. Although they argue that it’s lack of h2o2 produced by the mitochondria which is a needed signaling function: maybe so, but that h2o2 can only be produced when energy production is ramped up in the mitochondria (from the calcium signal), so if mitochondrial atp production is lacking, it won’t get that h2o2 signal either. And here’s the really interesting part. Excess iron in the mitochondria causes excess ROS via the Fenton reaction, producing super radical/hydroxyl OH from H2O2, which is very damaging. So it at the same time takes away the H2O2 signal needed by the treg to function. We shouldn’t throw all ROS in the same pot, these have opposite effects.
I think I’ve watched this before. Don’t think I have different conclusions. The point seems to be that mitochondrial dna gets mutated hence lack of energy. Is there any evidence whatsoever other than case studies? Would seem to be as rare as any genetic diseases. The idea is not well thought out. Since mtDNA inherits through the mother, any lineage with mitochondrial problems would never improve and quickly die out EDIT: unless there was a selective advantage which there probably is. As is known, US population has lost about half a degree of body temperature since 1940 across all age groups. The lower energy production which this is a sign of would likely be responsible for pushing these mutations to the edge of resulting in symptomatic disease. 37:55 this is I’ll founded speculation. Northern ancestors don’t need less coupling to produce more heat. First of all you have brown fat cells that can already do that, you don’t take away energy from every cell in the body. Second, people have been wearing warm clothes. I seriously don’t see what his point is. He goes on about breeding different mitochondrial mutations. If any of this was indicative of all the large increases in heart disease, cancer, diabetes etc then one could simply show that most patients share some of these causative mutations. Which clearly is not the case as all these diseases affect a similarly large population across geographies (eg in melting pots like the US), which mostly determines mtDNA EDIT: He shows that for some of the known symptomatic mutations, there is increased risk of Autism given certain haplotypes. I don’t recall the details but it was only significant in a few haplotypes, and risk factor < 2 for a low risk just says this predisposes you more than other populations, but isn’t an explanation why the diseases are on the rise across populations, especially as there doesn’t seem to be a rise in occurrence of these mutations. All I got from this is that the most common mutations are melas and lebers, which are rare, and have a very distinct symptomatic predisposition unlike what we see in he general population. 53:25 acupuncture works because it affects fascia which seems like a dynamic mold or mask around our body. Equating mitochondria with qi is a bit simplistic scientific, it’s pretty clear that most energy is produced in the mitochondria. Regarding Dr Wallace’s talks on mtDNA mutation increased heteroplasmy effect on disease and a paper that doesn’t see any correlation of the degree of hetplas with symptoms, it’s probably different haplotypes that make it appear random, ie some are susceptible some are not (can’t find the paper). He rarely mentions the fact that males are almost 10x more susceptible to develop symptoms, which renders his heteroplasmy graphs kind of useless for women. Regarding keto diet for improving melas, as he says a colleague is claiming, I’m looking at the evidence. But it doesn’t make sense to me because the mitochondria doesn’t see a difference between ketones and glucose, both enter it as acetylcoa. So if he sees a difference it’s probably just the standard claim that ketones enter the cell more easily than glucose in diabetes, nothing to do with mtDNA. For example, MCT transporters which move ketones into the cell, can be downregulated, just like the cell can become insulin resistant. Imo the cells are becoming energy resistant due to too much ROS, so it doesn’t matter if the energy arrives as glucose, fatty acid or ketones. In Alzheimer, downregulation of MCT has been implicated: Nitric oxide might be an inducing factor in cognitive impairment in Alzheimer's disease via downregulating the monocarboxylate transporter , 2019 “AMD3100 increases monocarboxylate transporters 1 (MCT1)” Subcutaneous Administration of AMD3100 into Mice Models of Alzheimer’s Disease Ameliorated Cognitive Impairment, Reduced Neuroinflammation, and Improved Pathophysiological Markers, 2020 EDIT: I have to say I’m utterly perplexed. Keto, which is a baseless fad in general, may turn out to be uniquely beneficial for the melas mutation? I don’t quite understand the results. They create a high heteroplasmy melas cell that has respiration issues and turns to glycolysis, then ketones turn it back to normal, but only starting after 2 weeks? Hard to speculate what’s going on. By replacing glucose for ketones, one thing that does change is the cell cannot use the energy from the initial glycolysis step, or even shift to glycolysis, to offload energy production. So maybe what happens is the forced usage of mitochondria over time shifts the heteroplasmy to a normal level, down from 90%, at which point it can produce more energy again. Also they casually mention that the control cells also generated 50% more atp after 4 weeks on ketones, so it seems that pure ketones for these in vivo brain cells (which never happens in nature) increases energy whether melas or not, after 4 weeks, which is a long time not running on any glucose. The addition of ketone bodies alleviates mitochondrial dysfunction by restoring complex I assembly in a MELAS cellular model, 2016
Many thanks. The acupuncture hypothesis was just too much for me. If the 'treatment ' was scientifically credible, why continue repetitive clinical trials? Is greater than 3,000 trials not enough?
@@tfoxen7518 I don’t remember what he said about acupuncture, but I recall from some paper that acupuncture effectiveness may be more to do with stimulating the fascia layer under the skin.
Your "financial and political" distractions severely distract from your science and research, something you know little about (ref. Insurers, lawyers, Wall Street; form reflects function) Frankly your presentation has a huge dose of BS. Do better.
ERMES simplifies the reproduction of Mitochondrion in Yeast/animal vs in Chloroplast/Algal - this is the molecular basis for old sayings “life is movement”.
the genius that is the mitochondria is magnified by science but that magnification power is small by comparison to that which is intuitive, the intelligence that is cultivated when we focus on energy through meditation and contemplation; that's where the real AH HA moments are revealed. it is always inspiring to hear young geniuses who keep tapping away on the inner workings of the energy hub that is the mitochondria; keep up the great work;
Thank you for a highly informative video in lay public terms! 👏🏽👏🏽 It is currently July 2022, is this video still relevant for the most part? If not or, if partial, is there an updated version somewhere? 🤔
Your slides are terrible! They are unnecessarily detailed and interfere with comprehension, not enhancing it. You need to make the slides much more focused and simpler. The fewer the words and symbols and legends, the better. Your verbal delivery is pretty good but the slides destroy it.
The disease was the poison you ate . The headache was the inflammatory reaction. It makes sense for surgeons to specialize. But diagnostics is thinking big picture , theorizing, testing
@@binathere2574 well no . Poisoning the mitochondria with coal pollution. Don't get me wrong I'm under IR right now . But the body can tolerate non ionizing radiation much much much better then mercury lead uranium and magnetic nanoparticles. Sorry . You can damage a cell with non ionizing radiation for sure or magnets. But the #1 killer on earth is coal pollution
I wish all researchers had communication skills like Prof. Jung Every scientific researcher should watch this as a masterclass on how to communicate your research problem to the layman This talk was perfect - full of insights, humor and got me excited about medicinal chemistry ! So glad the youtube algorithm recommended this to me !
There are FIVE information codes in every cell, aside from blood cells. The five are the DNA code, the mtDNA code, the epigenome code, the 'sugar' code that lines the surface of every cell, and the lipid code making up cell membranes. All these had to work in unison. The makeup of these for life are mathematical impossibilities-by-chance. To say the ribosome sums up evolution is ludicrous. That is defined as a 10^50 or more. It's far too complex without outside intelligence to make it happen. On top of this, the Intelligent Designer is a master chemist with 65 different hormones in the human body. We are a creation.. Not an evolution.
