Cool explanation. Thank you for updating us on methylation. According to your talk depending on the region hyper methylation can be repressive in some regions for gene expression. But not for some others?
Wow, that was a great explanation. Thank you. I read somewhere that inversion is the main cause, do you think it is wrong cause you said translocation somewhere in the video
A nucleosome is the smallest subunit of chromatin,formed by dna wrapping around an octamer of histones, dna being the string and the histone being the bead. Nucleosomes folding over each other condense form a more condensed complex of dna and proteins called chromatin, and chromatin condenses further to form chromosomes.
just want to clarify that there is an exception regarding methylation of Cpg islands where methylated islands can cause transcription only in case of igf2 gene
THIS IS THE MOST IMPORTANT VIDEO EVER, CAREFULLY PAY ATTENTION TO EVERY SMALL DETAIL IN THIS wow I watched this when this was on coursera and promptly forgot everything, until a thiel fellow refreshed my interest
does iPSC reprogramming decrease activity of repressive chromodomain proteins? Do repressive chromodomain proteins maintain differentiation? Also are chromodomain proteins more pro-longevity (keeping chromatin compact) or anti-longevity (potentially inhibiting translation of longevity-important genes like glycolytic ones)? [bromodomains rely on acetylated/open histones and are more pro-cancer/anti-longevity. with chromodomain proteins that rely on histone methylations, it seems way more complicated] (edited)
Very confused explanation, in last lecture she said, DNA methylation occurs at CpG island, in this lecture she said DNA methylation does not occur in CpG island, it occurs in intergenic region. And she often uses" probably," "it seems".......
