This channel considers new Technology discoveries in Anti-aging, the effects of Inflammation on Aging and with real example of Iron Overload as one example of medical conditions driving Aging. Why have we renamed the channel from Iron could kill you (the previous name)? The reason is we realised Inflammation has a significant effect on the symptoms of Iron Overload and inflammation is related to Aging. In fact Hemochromatosis causes aging to increase. So we are now very interested in Aging and Inflammation and with the huge successes currently happening in Aging Research this is now relevant to everyone - not just those with Iron Overload. We now use Iron Overload as an example of how Aging and Inflammation drives us into an Auto-immune response. This channel is now relevant to all people not just those with Iron Overload.
Thank you Robin for all that you do! I've posting the link to this paper. Claudia www.ncbi.nlm.nih.gov/pmc/articles/PMC9498654/#:~:text=It%20was%20concluded%20in%20this,appropriate%20pretest%20and%20posttest%20information.
yes correct, they're both rarely diagnosed, and rarely genetically tested. Type 4 rarely exists and Type 3 is nearly as common as Type 1 and neither 1 nor 3 rarely exist and the mixture of Type 1 and Type 3 also commonly exists.
I’m a carrier but have a history of anemia, low hemoglobin, and just had a bad episode after a blood donation (either a platelet or plasma donation, first time i had done that), where my BP dropped about 30 minutes after the end of the donation, and I had never had that happen before (regular donor). I am 54 and in menopause so no more periods to worry about. Is there another gene I should be looking into that might be a factor in iron issues affecting my blood pressure? I often have BP with systolic in the low 90s.
Thank you so much for making these videos! I live in Denmark and my doctor does not care to test me, so I am looking for a dna test kit but I have trouble finding any. Only test for US citizens of UK citizens available.
Had a genetic test done. Im a carrier of the C282Y gene (only one). My Iron Saturation was only 16%. Blood iron levels were normal, and TIBC was high, and Ferritin was high. My numbers have normalized since then. I eat a lot of red meat and I do take an occasional iron supplement. I do feel better when I take iron. But I also feel better when I give blood. What your opinion?
Im a carrier of h63d gene. I have many symptoms including RA and recently type 2 diabetes, the fatigue and lower back muscle spasms impede my life greatly. My gp is insisting im only a carrier even though im also storing iron. This worries me greatly that no one listens to how im feeling and just going by outdated information. Am i to develop cancer as a result before they take note!.
When my daughter was 3 she was diagnosed with cystic fibrosis. Husband and I are carriers. We were told for years carriers don’t have symptoms but we knew that was wrong as hubby and I along with many other parents had symptoms all our lives. I now found out I am a carrier of a hemochromatosis gene and my ferritin level was high. If I am just a carrier why would my level be high? From what I learned about the genes in cystic fibrosis, I believe being a carrier in any disease you can present with symptoms. If you have a car that runs on 2 spark plugs but one is not working your car may start but it gonna have symptoms of sputtering, the timing seems off, etc. same with genes…that can’t work well if one isn’t working.
Scientists do not know how a heterozygous defect in genes can determine the expression of a disease, sometimes yes and sometimes not. For the same reason that there are homozygotes who do not develop the disease. We are in a very early phase of understanding genetic diseases.
Told Im a carrier just yesterday H63D, I’m pleased I managed to find out why I have these symptoms ,all my own research I might add. Let’s get some PROPER research done scientists please. 🙏🏻I have Pernicious aneamia and now GH. Thank you for your Video. Very helpful
I am a carrier, I have liver overload with damage and I know others like me. There are still doctors who diagnose you as hemochromatosis secondary to anything.
I am a carrier of h63d, I have hemochromatosis and iron overload. My mother and my grandmother too. There are still doctors who tell me that it cannot be. 1200 ferritin and 50% saturation.
You petition is closed and have you done another one? Periodically there seem to be others stared that ive signed but ive not really been given any follow-up with how they got on or where they are in the system.
you are double heterozygous more likely to develop the disease. My honest opinion is that scientists are only beginning to understand how the disease manifests itself. Some doctors will tell you that double heterozygotes do not develop the disease or only mildly, all based on statistical studies only.
Hi I recently found out that I am a C287Y carrier and that I have a high ferritin count, however I would like to make contact with you to chat about genetics. I breed designer ball pythons and used combinations of genes to create new mutations, so through this I found several genes that are allelic that creates similar genetic outcomes in combination with other genes, there are also several examples of heterogeneous genes that would create markers of the visual homogeneous mutation. The relevance in the work you are doing could be to identify gene combinations that reduce / increase iron loading in the case of carriers or modeling the primary and secondary onset of iron loading due to a partial expression of the homogenous mutation linked with a secondary inflammation response.
My Husband just got diagnosed today as a carrier. Very interesting. Thank you for posting this video. His Doctor said he wasn’t going to affected, looks like that isn’t entirely true.
Hello, I have also been told I am a carrier (I have inherited 1 faulty mutation of C282Y in the HFE gene) I am 52 yr old female. I was tested because my 79 yr old father was recently diagnosed with haemochromatosis with a ferritin level of 700. His liver function is normal and he is currently having blood removed on a fortnightly basis. My ferritin levels and all other blood tests are normal. However, as a precaution I will have my iron and ferritin levels checked once every 3 years. I did find information online that suggested 5% of carriers may develop symptoms of haemochromatosis if they also have a faulty mutation of H63D (in addition to one mutation of C282Y) Symptoms can be so general and linked to so many other conditions. My dads condition was discovered purely by chance. It is worth noting that some people with haemochromatosis never develop symptoms (or only mild ones) so try not to worry if you are a carrier. Best course of action is to request ferritin and iron level checks every 3 years or so (my GP says this is straightforward and won't be a problem)
isn’t entirely true , near 95% of true maybe. The cases that I know of have the peculiarity that the disease usually manifests itself as carriers when they already have ancestors who have manifested the disease.
Around 21:55, I'm still learning about the most recent anti-aging studies & science. This is first time I've heard about NR. With the image you attached, I found "Tru Niagen" online and it's ocmponent NR is new to me. Thanks. I want to look up the ld50 of NMN and NR. Can they be taken in really large very amounts safely? I see that you reply to many of our comments. Thanks for the replies and great video so far. I have 10 minutes left.
I know David Sinclair takes a gram of NMN per day. He also takes resveratrol which he dissolves it in yoghurt before eating. I dissolve resveratrol in Olive oil. I take a lesser amount of NMN under the tongue.
Reversal of Ageing using lifestyle choices is possible to a limited extent, reversal is a tall order but feasible for a few years and then there is a relapse. Relying on a magic potion or magic pill is foolishness.
Not yet. It's early days there is a gene therapy in trials for Sickle Cell Anaemia, if/when this is successful I think we'll see increased usage of these techniques for other conditions. I do think it could be possible to produce an mRNA strategy which emulates the signalling for increase Hepcidin production but I think its 10s of years away to actually try to correct the germ-line genetic fault.
what is wrong with you ! You mention your web site that I wanted to visit, problem couldn't catch the web site name. Looked in description for it *Not There* At the very least you could have put it on screen so people could go visit it. Can't take a person like you seriously.
Interesting - i found out i'm a carrier of hereditary hemotomachrosis 2 weeks ago from 23andme, which apparently still increases my risk of iron overload. I have quite a bit of celtic ancestry so this is not at all surprising. Vitamin C also enhances absorption of iron; another vitamin that is often supplemented and overloaded in foods.
If scientists were able to somehow reverse aging in mice ,then how come human trials has yet to occured ? I`m willing to volunteer if no one else is willing to be tested . Only though if no pain is involved that is .....
When is comes to human trials the caution they take means that it will be 10-20 years before it becomes available to the likes of you and me unfortunately. They've been successful with the eye of a mouse the question is what other parts of the body can be reversed. Just in animals that investigation could take years.
@@aginginflammationandironov6371 I just turned 30 few days ago . Does that mean I still have an chance of obtaining " age reversal medicine " or will it be too late by then ? I don`t know how it`s gonna worked on middle age men
Others have been working with Stem cells but David Sinclair is using a technique which pushes cells back in time but not as far as stem cells which do know their cell type - his cells keep their cell type so there should be fewer risks of cells turning into the wrong type
well put together and instructive video, nice work. Tragic how almost everything is pushed 10 to 20 years down the road: fusion, going back to the moon or mars, hydrogen as a power source, ...and effective cures for ageing.
Yes agree. Incidentally we can get fusion power now... its called solar panels and a lot easier than building a sun on earth. Agree though that the hard thing get pushed back and both fusion and the body are hard and complicated - both will come.
@@aginginflammationandironov6371 sir , you said in the end of the video , that reversal of aging in animal has been demonstrated to work ) but as far as i've found , dr sinclair only managed to make a mouse grow older faster than it twin (by scratching it's DNA ) isn'it ? ,,,,, i mean..is there any other experiment that he did on older animal and made them young ? i would love to see that
@@jaimenazaryan860 I think he's talking about the experiment where they damaged a mouse's nerve cell and then made it grow back. IIRC Dr. Sinclair referred to this as reversing aging in other interviews. You bring up a really good point though, he hasn't even demonstrated safe age reversal in animals yet (Im subject to correction here).
Excellent presentation. Two small points I would like to clarify. One, The SENS Foundation actually is working on repairing the damage from aging. I spoke with Dr. Aubrey DeGrey after a presentation at OSU School of pharmacy about 11 years ago and one of the major research areas they were funding was the search for non-toxic compounds to undo cross linking in protein molecules. Another was a search for compounds to break down or remove intracellular and extracellular waste products like lipofuscin, beta-amyloid, et. al. As you pointed out more recent studies have shown at least some of those "waste products" like beta-amyloid may have a beneficial protective function. The second point is the problem of doctors looking for "one effect" in research is not specific to medicine. It is a result of the reductionist scientific method that seeks to simplify the problem to an "either, or" logical situation that can rule out all other chance occurrences. This method is both its strength and its weakness. It has allowed science to gain an understanding of complex systems that our poor human brains could not possibly comprehend in their full complexity, but it has also blindly ignored that many phenomena are the result of multiple synergistic effects that when some are isolated, removed or ignored change or destroy the essence of thing that is being studied. In some cases this can be overcome with more complex, sophisticated multi-variable statistical analysis methods but this requires the biologist or medical doctor to also be an advanced mathematician. But even then some troublemaker will invariably ask, "how do you know you have included all the variables in your model"?
Both good points. I think Aubrey deGrey was trying to dumb down his description so it could be understood. I do think there being a natural genetic/epigenetic based repair mechanism like that described by David Sinclair (if it can be proved correct), could be a more fundamental approach than solving repair for each aging mechanism - let's see who is right. I agree with the point about Science trying to simplify. In Physics we have Occams Razor which basically says the simplist idea is the right idea and certainly in Physics it tends to work. But in Biology none of the ideas are simple and everything interworks with everything else. When I hear a doctor saying Hemochromatosis is the result of a single gene (monogenic) I think they've made the mistake of thinking it can be simple when it isn't. Whereas the scientists do say it polygenic.
Why are so many companies in the anti-aging space say they are producing anti aging medicine when their products seem to target disease after manifestation....i.e. same old treat the disease not the cause . Other than a couple of over the counter supplements there is no general treatment even though there are now hundreds of companies in the space.
Yes, another good point. I think the fundamental idea that epi-genetics are involved will bring everything down to single treatments for all aging diseases (it might be wishful thinking of course - see might comments about nothing is simple in biology). An example of this is a sick person having a healthy baby - this is a form of anti-aging where the memories are lost and the genetics diluted.
As near as it seems as far it is actually is. I feel like it is 50 years away at least the way things go. All is slow...way too SLOW! another promising molecule on mice and another one every few years. We are NOT mice! the ageing process in people is much more complicated. I remember the breakthrough of Resveratrol 10 years ago then what...we are not even in the stage when we have someone already proven to reverse ageing on himself. Even if we were at this point...then we will still need funding and talks to organize safety trial...then bigger effectiveness trial and more tests and prolonged data. Then we will have decades of talks and regulation issues to overcome with FDA and other parties (the population doesn't see ageing as a disease). Then scale it and bring it to the masses in a reasonable price. I am in my 30's and I feel like it might not happen in my lifetime. Hope I will be proven wrong though.
Well I hope it does happen in your lifetime. I agree that the medical methods are very time consuming and progress can be too slow to see sometimes, but I do think it will happen some time.
@ironcouldkillyou Firstly thanks for the great videos. I have recently found out I have hemochromatosis by doing a 23 and me test and a Thirva test which showed my ferritin levels as being high. It has been confirmed and I am going to start donating blood next month to reduce iron content. I caught it early (I am 38 and my ferritin is 400). I was told by the doctor that once we get my ferritin level down to around 50 and maintain it, it would be like I don't have it, i.e. the iron won't do any damage. However, watching one of your videos (I forget which one) you mention that it causes inflammation which can lead to other diseases like diabetes. Can you tell me if the inflammation would only be present if my iron levels were left unattended or if it's a non issue now I have caught it? I realise this is not medical advice and I should do my own research etc. Thank you!
If you peaked at 400 then you should not have done too much damage so its true if you get to a serum Ferritin of 50 and Transferrin Saturation<50% you should be be symptom free. That's the simplified view... the reality is once down to 50 in what they call maintenance and you then donate every 3-6 months to maintain below 50 for the rest of you life. As you do maintenance cycles you may need to donate at longer intervals. Also in the first cycle people often find their Transferrin Saturation>50%... this needs to stabilise over perhaps more than 1 cycle.
Brillianty all put together the latest reserch in this short video explaining the complicated science simply .I personally think we are very close in a few years for the cures to happen which is why videos like this need to be shared to more people.
Thanks for your kind words. I do think we're on the verge of the biggest medical break-through ever, as its not only reversal of age but also curing many of the inflammatory diseases we see in the old too.
@@aigirls9927 what do u mean ? u mean that if he's too old it's not gonna work, right , ,,, what about a guy in his mid-thirties ? thats young enough right ?
Reversing ageing is not about changing DNA at all. It's about change the methylation on the DNA and I don't think it cannot be changed everywhere. But clearly we don't yet know how to do this.
@@aginginflammationandironov6371 but according to dr sinclair it will hopefully be done in the next 20-to 30 years right ? ....then old people can turn young again right ?
It's different for different people dependent on how much iron is in the liver. This is an accumulative condition which increases as you get older as the iron builds up. The earlier someone is treated the less damage is done. With carriers just a few blood draws can be done. In my case it took 9 months with blood draws every 2 weeks - once the levels are down then every 3 months I get 1-3 months for the rest of my life. I have heard of others where it takes years to get the levels down.
I am getting tested for the gene today. However my ferritin levels are only 555. I’m not sure what’s going on because I have low/normal saturation. The Doctor is baffled. I feel very tired and have a host of symptoms. I also have slightly elevated CK levels. Did you experience any vertigo/dizziness?
@@22killakush22 High ferritin can be caused by inflammation or Hemochromatosis. If your levels fluctuate a lot and you have low saturation then less like Hemochromatosis. However of you have the hemochromatosis gene mutation(s) then its more likely one of the weaker forms such as compound C282Y/H63D or homozygous H63D or even a carrier for C282Y or H63D or even S65C. I certainly get very easily out of breath and this could be interpreted as vertigo/dizziness I guess.
Thanks Robin... Your absolute selflessness and drive to educate is commendable. I do hope members of the medical profession will watch your videos and rethink their position on HH / carriers of the C282Y and or H63D gene variants and results of iron loading and damage at a cellular level in the cases of either Heterozygous and Homozygous instances. Also further educate themselves with the help of your research on bio markers / predicting age and possible illnesses and related symptoms through DNA at Check Iron checkiron.com/ci/index-v2.jsp#home 👀
