This course is just amazing! thank you Brianne for posting it online! I've binged through all of the lectures in 1 week - I just couldn't stop. (skipped the first lecture due to the sound issues - the rest of the lectures are fine)
800 views and no comments. This is concerning. Hi Brianne, I was only told about you today, am shocked and surprised nobody has mentioned you that you have this huge source of educational lectures. I hope people have appreciated your efforts. I'm working on a survey of how people have failed to learn t cells immunology over the last four years. Scientists to FDA in 2022: "don't forget the T cells". Forgotten worriors. Hidden assassin's. Serial killers! It's like everybody HAS forgotten them! You sound very enthusiastic. Im going to sit and work through all your lectures and give you responses you deserve. This is exciting! You sound really friendly too. Wait. Are you one of the TWIV team? I'm sure I recognise your voice.
1000 views and NO comments!?!? We have been in an immunology crisis for 4 years and nobody seems interesting in the most important half of the immune system ??
2.7 thousand views and only 3 comments. All three comments don't talk any science, they only critisice "performance". This is exactly the same response i have had in four years, after thousands of videos. Nobody will discuss the subject with me. Interesting.
Hi Brianne again. I'm just going through all your videos and surveying for intelligent communicative responses. This video is 4 years old, 2 thousand views. And only one comment? That seems uncharacteristically low. Almost like the whole world decided to ignore T cells role, and only focused on antibodies?
Hello Brianne. You don't appear to get anyone commenting or asking you questions. Despite t cells immunology being central to COVID and mRNA. I am curious to hear about how you have coped his last four years. Sorry to ask, but have you found people being bizzarly distant, disagreeable, and unresponsive, or uncharacteristically difficult and condescending with you?
I have a question, if C3 spontaneously cleaves and can attach to basically any organic molecule in the body, can it attach to a normal nucleated cell that is displaying an expected peptide on MHC I? Or attach to an MHC II displaying a peptide? If it can then what happens to that cell?
Does an adult normally have circulating CD28+ T-cells outside of infectious state meaning without an obvious acute activation? CD28+ % CD3+ ? Is there a reference as to what would be suspicious and maybe represent an activ antigen presentation?
What about the integration of gene repressive markers such as JMJD3-mediated H3K27 as silencing the innate immunity and allowing the transcription of genes with a TH1 linneage signature?
As I interpret Parham figure 9.22, slide 11, it would seem that there may be some fetal IgM being produced, along with maternal IgG. Would we see an increase in fetal IgM concentration if there is an infectious agent present in fetal circulation? Thanks for the great videos!
It doesn't work this trement thay just wont your money becarfeel i have been there done thay thay tookmy money and said thay couldn't be any more for me
This immunotherapy does not work thay just take your money and promise and lie to you that it is a wonder qure for cancer and its not 9 thousand And 5oo$ Dollars in new zealand per trement
thank you professor Dr Brianne Barker, for all your courses on youtube. it is really great support, you have enriched my immunological knowledge. best wishes for you and your loved ones.
Great lecture, but I'd like to make a correction: IPEX syndrome primarily involves a deficiency in peripheral tolerance, rather than central tolerance. This distinction arises because, although regulatory T cells (Tregs) originate and are selected in the thymus, their critical function in maintaining tolerance occurs in the peripheral tissues. Their role in controlling and suppressing immune responses to self and non-self antigens is crucial in preventing autoimmunity, situating the dysfunction seen in IPEX within the realm of peripheral tolerance mechanisms
Advice to Brianne. Great lecture series, but please repeat the question before answering it because otherwise the question from the students doesn't get captured on audio.
Is it possible for you to share which book is used by your students and which pieces of text are required to read as a supplement to the lectures? I am trying to self-study immunology and knowing what is important to study would make it a lot easier.
Thank you for uploading the lecture! I find it tremendouly helpful. I have one question about light chain testing. Does the lightchain undergo any positive selection? How does the cell know it has a functional lightchain if any signaling from IgM is considered reactive to self antigen and signal negative selection?
I wanted to express my sincere appreciation for your outstanding teaching in immunology. Your unique approach has made this intricate field more accessible, especially for medical students like myself. Your ability to simplify complex processes into a linear and understandable format has been invaluable to many of us. The clarity of your videos is not only helpful for initial understanding but also serves as a valuable resource for review. I hope these resources continue to be available as they greatly contribute to our learning experience. Thank you for your dedication to making immunology more comprehensible for students at various levels of education.
I am really appreciated for the whole classes! It is really a systematic class. But in this lecture, I am confused about the peptide length the MHC I can hold. Is the length fixed or varied for individual MCH I molecule?
Pfizer and BioNTech are seeking to hold Poland to its commitments for COVID-19 vaccine orders placed by the Polish Government, as part of their contract to supply the European Union signed in May 2021," a Pfizer spokesperson told Politico, adding that BioNTech is joining the lawsuit. According to Polish newspaper Gazeta Prawa, Pfizer brought the civil case before a Brussels court because the doses were purchased through EU joint procurement contracts, drawn up under Belgian law. -Politico Poland, under the leadership of then Health Minister Adam Niedzielski and the populist PiSparty, took a bold step in April 2022 by stopping vaccine deliveries, citing force majeure. This decision, influenced by both financial and epidemiological factors, echoed across Eastern and Central Europe, leading to a wave of dissent against the Commission's deal with Pfizer. POLAND DOESN’T WANT THE HORSE PISS
Pfizer Sues Poland For Bailing On COVID-19 Vaccine, Citing Shady EU Mega-Deal Tyler Durden's Photo BY TYLER DURDEN SATURDAY, NOV 25, 2023 - 07:15 PM In April, 2021, the world learned that European Commission President Ursula von der Leyen had been negotiating the biggest contract ever sealed for 1.1 billion doses of COVID-19 vaccines via text messages back and forth with Pfizer CEO Albert Bourla.
