The ME/CFS Collaborative Research Center (previously known as the CFS Research Center) at Stanford University was established in 2014 and is part of the Stanford Genome Technology Center. Both centers are directed by Ronald W. Davis, PhD, Professor of Biochemistry and of Genetics at Stanford.
Very impressed by Dr. Davis' hypotheses and I am enthusiastic about the concept of the metabolic trap. But as a professor myself I think he explanations would REALLY benefit from some slides and many animations. Laypeople simply do not understand enzyme kinetics and metabolite feedback.
There's a RU-vid channel called Ribeye Rach. Rachel had a huge list of issues, including ME and she did Carnivore plus other visualization and she's so much better. Lion Diet cured my Dishydrotic Eczema that I had since I was 2 years old. I think it completely redid my gut flora. I'm 49 years old now! There's a guy on here (Homestead How) who got rid of a heart murmur and irregular heart beat. I thought heart muscle can't heal, but what if it can! I hope you look into this Dr. Davis. Thank you for all your efforts! My great grandmother used to scrape mold off of bread and feed it to her kids when they were sick. Later, penicillin was discovered. Sometimes anecdotes can lead to discoveries. Good luck with your research!
Thank you so much for your dedication and research to find a cure not only for your son but for all of us. To say I’m grateful for all that you are doing doesn’t seem like a big enough word. I pray for more funding for this research, I think once you find the cure for ME/CFS this will also be a cure for Long Haulers Covid patients as well. Bless you Mr Davis, stay well.
After 30 years of having this and doing my own research I am hoping before I die someone finds out the cause of this nitemare. I have a study published in 2000 medical journal. Started and facilitated a support group for this at local hospital for 23 years. I was diagnosed during the Incline Village breakout time about 1988. Problem money for this research has been lacking till recently. Most new people don’t even know about this time frame in the 80s. Hopefully for us and the Covid long haulers there will be help someday. This disease is a thief of life stealing years of days and nites that we will never get back.
I am bedridden too due to CFS plus other symptoms like neuropathic pain in both arms and legs, too drowsy during the day and insomnia at night, extreme food and supplement or even RX sensitivities, joint pains, brain fog/memory loss, etc. For me it started when I took multiple antibiotics for extended periods of time like couple of years for Lyme, Sibo, lung and bladder infections. Holistic medicine says that antibiotics kill not only bad bacteria but also good ones and somehow it’s true for me as I don’t have lactobacillus and Bifido strains. Also, this caused leaky gut or increased intestinal permeability causing autoimmune diseases. The problem is if it’s severe, people are unable to tolerate probiotics due to Mast Cell Activation or histamine intolerance. Those who tolerates probiotics at therapeutic strength are able to get better or cured. I hope you could also look into this and ask Functional MDs regarding this. Thanks
I discovered Ron Davis 9 years ago after I got sick from CFS. I have much hope in Ron and his team and others and have been following the research for these past nine years. I'm 75 now and still hope that there will be a cure before all my time runs out. Thanks Dr. Davis.
God bless you and your son, my son is in the same medical state as your own son and has been for 18months now, most UK NHS services telling him the same old fashioned "get out more" "you need CBT". Thanks for all your doing and giving us hope.
I am recovered from ME/CFS but when I was ill, I used to get bad allergies. Now, I don't get any allergies. I think there must be a correlation so something is happening in the immune system as one of the things gone wrong.
I was told I have a defective tryptophan transporter gene. Is that the same thing? Am I understanding correctly that we should never take tryptophan supplements?
What's helped me : Rest, low stress lifestyle, ASEA redox signaling molecules, high dose vitamin C, NAC, low carb, intermittent fasting (OMAD). Gut health with homemade sauerkraut daily. Putting my health needs first everyday and letting the rest of the world go on turning without me.
Thank you for your dedication, Dr. Davis! Long before C*VID, my geographic area had several outbreaks of "unknown" "really tough" viruses, so labelled by our small town doctors. These monsters began like mild upper respiratory illness and in about 48 hours the GI tract, mostly intestines, were attacked. Neurological symptoms followed for some and those who had neurological symptoms had difficulty recovering or never fully recovered. Such patients were then labelled mental which is a fairly common procedure in the U.S. No one knows how many people drag through life, or who have given up on life because of ME/CFS or other sequelae from extremely nasty, unidentified viruses.
Screen for borrelia miyamotoi through redlabs, my doctor sees is in almost all of his ME patients. IV abx for the co infections (too many to test for so treat it anyway) and then oral disulfiram with serrapeptase. Dont wanna test and wanna just know if you have it? if you feel worse on abx or disulfiram, you have a borrelia infection. spirochete bacteria are the only ones that make you herx.
Thank you for your tireless efforts! We’ve all seen the stat that if you’ve been severe for 5 years, you’re not likely to improve. I’ve been severe for seven years now and continually deteriorate further. My (little 😅) brain is trying to comprehend how that scenario fits with these theories? I was very severe at initial onset twenty-three years ago, relatively mild for fifteen years (with some brief moderate to severe episodes during that timeframe), now apparently permanently severe, homebound, almost entirely bedridden, and miserable. My return to severe about seven years ago was triggered by Hashitoxicosis. No idea if I could have rested my way out of this return to severe, as I didn’t get an accurate diagnosis until two years ago and didn’t realize how critical it was not to try to push through. I desperately wish I’d have known, and desperately wish for a cure. You all have my prayers and whatever financial support that I can manage.
Thank you for your work on this, it doesn't go unnoticed. Have you ever considered that traditional plant medicines might be helpful in breaking the above immune response loop that you described? Thank you 🙏
Cptsd, trauma, can cause it as well. I had it and healed myself. It can heal. Part of my healing was not to have crashes, i had to develope my day to what was sustainable with out a crash. Id do that for a few days, then id up my game the fourth day, just a tiny bit. Sometimes id do my routine for up to 15 days before id increase my activity just a bit. This was alot of trial and error until i found my pace. I started mostly bed bound, today, im a yoga teacher amd weight lifter.
I remember Dr. Robert Phair's presentation in 2018, which was about IDO2. Now, we're looking at IFNa/Itaconate. It's frustrating that, despite donations to OMF, we're still in the hypothesis phase for understanding these metabolic traps. I had hoped we'd be doing small clinical trials like those with JAK-STAT inhibitors etc. While I'm disappointed with the lack of progress, I appreciate the researchers' hard work. Funding is crucial for scientific advancements, and we can't expect quick results without it.
