The International Agency for Research on Cancer has estimated that about half of all cancers could be avoided if current knowledge was adequately implemented.
ecancer is a UK charity, working tirelessly to ensure current knowledge is properly shared. Our mission is to raise the standards of global cancer care through education.
We were founded in 2007 by two inspirational oncologists, Prof Gordon McVie and Prof Umberto Veronesi. Frustrated by global inequalities in access to education and research, they were driven to create an open platform to share knowledge that would help raise the standards of cancer care - ecancer.org.
I lost my mom two months ago Lenvatinib is useless treatment This drug has very bad effect This medicine causes many diseases in the body Kidney failure Blisters on the body Pus in the body Constipation And there are many dangerous side effects
So far the combination has worked for me. 8 treatments with the EV lowered from 1.7-.75 down to .50 now. At 1.7 experienced Gi toxicity and was prescribed bentyl 10mg. Definitely experiencing neuropathy in fingertips, rash, some mild depression, anxiety, fatigue, loss of appetite in the beginning along with no taste. Petscan clear tumors gone in lungs, liver, and abdomen after 8 treatments. Started as bladder cancer urothelial papillary carcinoma. Radical cystectomy was performed with neobladder. Last year 2023 October ended chemo treatments, cisplatin and genmar. Following up with a few more treatments of keytruda and padcev (EV) then Petscan in three months. 🙏
I would only hope that it is as effective as indicated, and that it is available like yesterday. While you might not want to hurry any drug along because of possible side effects, ineffectiveness, etc., for those who are terminal what is there to lose? I also hope that it is affordable. I think everybody should pay at least something, but put it basically into the public domain like the poliio vaccine. No big pharma gazillionaires from this breakthrough drug, thank you.
F63, Diagnosed with rectal cancer. Completed 25 days chemoradiotherapy. Post therapy MRI result shows favourable response to treatment with minimal residual disease MRTRG2. Can i opt for non surgical care?
I received an email from Cidade da Esperança informing me that phase 1 of the AOH1996 trial is suspended at this time. I understood why. The trial list is already full. They shared a link for testing, but for other medications. But from what I understand, phase 1 studies are continuing.
Why are so many unaware of the cost of medication and treatment research and development??? Ongoing medical research, especially for the endless types of cancer, is focused on finding safe and effective treatments, which in the U.S. cost to make it to patient care. Many never make it to human trials. Does the public expect private companies to simply absorb the loss?? That will clearly inhibit and reduce further research and development. The government allocates a limited amount of funding.
Dr. Malkas, (please fwd this comment) I am very impressed with your work, and enjoyed your visit with NGT on StarTalk. As a physician not in the field of cancer research or treatment, I applaud your transparency and candid communication related to cancer formation and treatment. May your work be productive and help many.
The first thing, even if the drug will be approved, only the rich people can receive this treatment. and will past another 5-7 years until will be on the market. For my very sick wife it will be too late....... 😪😮💨
There may be resources to help pay for treatments not covered by health insurance. Check with your cancer physician for options. Also the American Cancer Society. Typically no assistance will be offered unless you pursue it. Best of luck
@@old-n-gettinolder Thank you for your advice but we are living in Israel and the medical system did everything for her. Even if there is no hope they are still take care of her....
My intro : I have metastatic breast cancer, Liver and bones, Er+, PR+ Her2-. I am a 55-year-old mother of 4 kids and post-menopause. Condition: No physical pains, Feeling normal but weak. Eating normally. I've been on a regimen of Palbociclib and Letrozole for the past 19 days, and recently, I received my CA153 test results. Last month, before starting the Palbociclib and Letrozole treatment, my CA153 level was recorded at 137. However, today, my most recent test indicates an elevation of CA153 =267. Platelets low to 159 WBC 2.9 HB 10. Before that, I had 15 weekly Taxol (paclitaxel) sessions. Until 12 sessions, CA153 decreased to 83 but again started rising to 137, so the Doctor prescribed Palbo + Letrozol. Started pacli from 142 CA 153. So can you please provide your experience? Does Palbociclib and Letrozole take longer to work? Should I give more time to see its result ?
I apologise for my diminishing grasp of biochemistry, as it has been quite a while since I studied the subject at university. However, I would observe that AOH1996 looks somewhat like an aminated analog of acetic acid. For info, amination is formation of a carbon-nitrogen (C-N) bond in an organic molecule (typically achieved with ammonia, amines, or other nitrogen-containing nucleophiles to organic compounds). Perhaps other RU-vid follower with better background in biochemistry (or organic chemistry) could offer a more useful view? If my guess is correct, it should be relatively easy to synthesise this molecule by nitrating vinegar for example, assuming that the trials will continue to show promise - but not before all tests are concluded. Whatever our reservations, science is our best ally. Best wishes.
I guess the main problem is the American Money Association (also known as AMA). IF it CURES, that's bad, no profit. IF it's not EXTREMELY expensive, there is no profit. Sad, but the AMA is probably the biggest cancer going on.
Well, Cancer IS one of biggest profit centers in the industry. It's a bit like Co**id. Every ventilator-dead person resulted in a cost/profit of $1Million+ Multiple times as many /100000 as in Germany. There IS a $ystem going on. We had the highest hospital deads. I hope that OAH1996 can SHINE in some other countries, and it will be made known where, and then patients can flock there and get cured.
What you have to understand is that the medical industrial complex will lose incalculable amounts of money. The Germans cured cancer in 1944 and the medical community has been killing us for decades.
I hope you guys will give some great news for the next looks like in September in 2024 , hopefully going to phase 2 data comning out@@ecancerorg. I would think if the data is great, then phase 3 it will be mass produced
I have a dog I need to try it on hes like my child , I want to save him , he has a large tumor way down the base of his toung they cant operate on it they said it will eventually cut off his food and water in take😭 does any know of anything I can try😭
I believe Dr. Malkas is deliberately playing down or lowering expectations for AOH1996 (calling it an "olive" for instance). However, if it works on humans as well as it does on animals, it's going to be a game changer just like GLP-1 and GIP agonists are for diabetes and obesity. We are living in exciting times in the field of medicine.
If you search online, many sources say it started the human trial on the first patient in 2022. Now they say august 2023. I hope I am wrong but I do not like it.
@@73maxoneit My understanding is that they are testing the drug for safety at this point. That usually involves testing it on healthy people. IOW, they are following the FDA's procedures for testing and approval of medications.
@@VernCrisler You would think that way…but no. As cancer patient I can tell you no, the normal way in these cases, given the enormous risks of adverse events (90% of trails fail phase 1) it is given to late stage patients. But you can check online, it does not let me paste a link to one of the many official sites. One of the paradox is in fact that from time to time they discover that a last line drug would work better as first line drug.
PCNA stands for Proliferating Cell Nuclear Antigen 1. It is a DNA clamp that acts as a processivity factor for DNA polymerase δ in eukaryotic cells and is essential for replication 12. PCNA is a homotrimer and achieves its processivity by encircling the DNA, where it acts as a scaffold to recruit proteins involved in DNA replication, DNA repair, chromatin remodeling, and cell cycle regulation
So how many individuals were tested total and how many had new cancer detected? I am welcome to new information though. Please present links to these followings, so I may keep up.
I can't listen to this. How many, many times have we heard exciting news about a new cancer "cure" and then never heard about it again? Something is going on here. I don't know if the drug fails clinical trials, and then is withdrawn from FDA review, or the drug actually works and for some reason is not FDA approved. There may also be big Pharma dollars or even political considerations involved in all this. Whatever the reason, the American people are deliberately kept in the dark. Why?
first patient was given this pill in 2022 (there are various articles about this online), now you are saying that phase 1 just started and recruiting (for 8 subjects) is still ongoing....this is quite confusing...
When you look at the current study it shows that patients are giving doses for 28 days and start the cycle again if disease doesn't progress or there isn't unacceptable toxicity. Phase 1 started in 2022 and it looks as if study ends next year.
@@Schnellanie correct, trust me being an (ex) researcher and a cancer patient myself I know how to read studies. But this conflicts with the statement that the first patient has been dosed in August 2023 then.
I think the first trial is using healthy people, so they can find the right up-dosing schedule -- toxicity, side-effects, etc. I guess it's the FDA's do-no-harm requirement.
@@VernCrisler if FDA's has "do-no-harm requirement" then tehir wont be any Chemo drugs out there...FDA will delay this as long as possible because this can impact Chemo drugs sales
It still is in trial phase and doesn't seem to be offered in other countries. Depending on where you're at have a look if you can get Mistletoe therapy for your mom, it helped me a lot recently and without it I wouldn't be here anymore. Wishing you all the best!
Why not making it public so other researchers can put efforts on it? Other clinical trials can be done in parallel. Most important, whoever in the pharma industry or related cannot stop it. They "buy" everything and shutup everybody. The economical impact worldwide is huge. You cannot just keep it in one hospital and research center. Make it free and spread the knowledge.
@@VernCrisler My wife has grade 4 Glioblastoma. W would gladly take any risk to save her. If the FDA "expedited" any of these promising trials like they did the COVID vaccine, they could possibly save or add several years to patients around the globe that have little or no hope.
@@VernCrisler They are just killing time. It has been known since 2022 that AOH1996 is non-toxic. They probably are cracking a deal with big pharma to either sell patent or delay the trials so that their is no impact on sales of patented drugs for next 5 years
That’s not how science works. You test, and then publish for other people to review it. Also suspending progress on other treatments would cause more harm than good. There are hundreds of forms of cancer and this doesn’t treat all of them.