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Thank you very much indeed for such an informative lecture. I started taking Mavacamten, here in the United Kingdom, only two weeks ago (we are behind the US in distributing this First in Class medication). So it is early days but I remain cautiously optimistic. Whilst I have tried to keep up with the trial data for these CMI medications, I found your discussion of the clinical management very helpful. The possibility of long-term remodelling remains tantalising, but for now I need to be cautiously optimistic about receiving improvements in my symptoms and NYHA status over the coming months.
CAC is a late manifestation of atherosclerosis. We don’t have to wait for CAC > 0 to treat the patient. The most spartan of diets associated with exercise would reduce LDL and Apo B to what level? 10%? 7%? It is impossible not to use drugs to reduce cholesterol and MACE.
Atherosclerosis is not a inexorable condition . Is there a level of ApoB that that if maintained throughout life would not let plaques to build up ? ApoB less than 55 mg/dl for instance .
