31:24 and 37:34 what about titrating a single dose into two treatments? It seems that you could treat with the initial dose, at say 3/4 the overall treatment dose and once the tumor has started to degrade (> 4 months?), administer a second dose of the remaining 1/4 dosage for a two treatment regimen? One safety mitigation would be the overall dosage does not change, only the treatment regimen and the tumor stage associated dosage. One endpoint could be the scaring residuum. It would be interesting to track the duration of the ‘honeycomb’ tomography to see if by somehow extending this stage the end result is a more efficient and effective tumor degradation. Also, a two treatment regimen may provide a kind of compensation factor for a weaker immune response in some patients. Oh wow. I just reached this part of the presentation! Very similar idea. That’s great.
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Thank you for the information I found your information seeing that you are on ricardo komotar"s podcast He did my husband's surgery twice. The first time of diagnosis and when it came back. There is so little information about GBM
Hi and thanks for informative presentation. I have gbm that was diagnosed in February 2023. I had surgery followed by radiation and temozolomide for 40 days. I had a good recovery. From July to December 23 i had chemo temozolimide higher doze. But, in decemer 23 i had an mri that a recurrence and doctor prescribed avastin and irinotecan for six sessions each taken every two weeks. Tolerance has been relevatly good. My query is whether is it possible to participate in the these clinical trials after current avastin/ irinotecan?
Devastating loss to the brain tumor community. RIP Cheryl! Cancer didn’t take you because you kicked its butt! For those wondering, Cheryl passed this December after having complications from her recent surgery.
Can this be used just after a patient starts using Optune or is it limited to patients who just completed radiation? How does someone get accepted to clinical trial?
The standard device can not be used for DIPG as the electrode would have to be placed too low on the neck making it uncomfortable. I have heard that they are developing an new style of array that ight work in that area but it is not available yet. Sorry.
Mr. Musella would it be possible for Duke to discuss adult trials as well? I know they are a top institution. Very curious what they arent disclosing that they are working on.
Actually, why don't you tell the 13% that lived greater than five years yourself. Look at the combo trial data, it's some of most awe-inspiring cancer data known to mankind. Maybe you are just a little jealous of Dr. Liau😊
The times coming close, and clearly this doctor is nothing but a paid shill. I'm glad 70 other doctors signed off on it so that your simple-minded opinion is all but muted.
Guys an idiot, how in the world can he sit there and say DCVAX-L does not work when we have numerous patients still alive today. Does he even know what JAMA stands for ?
I just found a doctor's report on how ALBIUM was used in an IV with curcumin for high-grade brian tumours and they have success, how can i get this info to you?
@@musellafoundation There are Plenty of medical records and evidence from a German Oncologist who published an Astrocytoma gone among others, I can send you these reports, I see you have not studied Ruta 6 yet either.
I got one the size of a pea it's being watched if it grows I'm in for a huge journey of nothing but a harsh road ahead ,they said it's operable and I'm hoping it doesn't grow ,but if it does I'm doomed 😢
It is not available at MSK. This particular trial is at clinicaltrials.gov/ct2/show/NCT05362409 and a similar trial is at clinicaltrials.gov/ct2/show/NCT05370508 2 different approaches to the same concept. We do not know which one is best yet but both are worth trying
There are a lot of treatments that some doctors use and others do not. This is a relatively new technique only used by a few people. Same thing with Optune. Most doctors use it but others do not like it and won't tell you about it.
Because dcvax-l DEPENDS on the patients own immune system to work and the health of patients vary greatly, the results should be considered with that in mind. A doubling of OS is amazing. Combination therapy should provide a much greater benefit. Eliminating the toxic SOC should also benefit DCVAX, a combination with Optune.. very interesting.
Thank you for this presentation -----Love the straight shooter approach.Please help with DCVax approval if you agree.I think we will hear more positive news about it after the approval. KB.MD.FACC.
@@pechaa Yes - he was not the scheduled speaker. Dr Linda Liau was supposed to speak but she caught Covid and couldn't do it - so he presented Linda's presentation.
My 7yrs SON passed on 26.AUG.2020 with DIPG but peacefully. I did research and thought many factors and advised following for one girl patient in Pakistan and she got cured miraculously got rid of tumor and MRI After shows NO RESIDUE tumor. Please try following for 7 days if positive result continue. Can increase or decrease qty. 1) Oral consumption of Extra Virgin Olive Oil (twice a day one table spoon) as pure or in some food. 2) Natural Organic Sources HONEY (three times day tea spoon). If you get multiple kinds/sources try all of those in little qty. 3) Himalyan Pink Rock Salt in WATER over whole day span or in food (one tea spoon at least a day in divided over wholeday) 4) Sunrise and Sunet time soft DIRECT Sunlight 1 hr directly over head, neck, backbone DAILY 5) All seasonal fresh fruit and Vegetable juices (the maximum range avl of the season) 6) Maximum Time in GREEN OPEN areas with MAXIMUM clean fresh OXYGEN 7) Play "SURAH RAHMAN" near child can hear while sleeping or awake either and keep water near during play and use that water oraly.
My dad was just diagnosed with stage 4 lung brain metastases. He can't have surgery to remove his largest tumor (3x2in) because its connected to his blood brain barely and if he had tumor removal surgery he would bleed to death. My mom is killing herself getting my dad everywhere he needs to go. They have to travel to Houston on different days, sometimes having to pay for hotels for days and they spend so much time driving from doctor to doctor. They are down to their last $100 because they have been spending so much money on premiums at every appointment. It's been very stressful and hard on both of my parents. It's been hard on all of us. We can't lose my dad. My parents are best friends and they have been married for over 40 years. If we lose him then I would be losing both of my parents because my mom says that she can't go on without him. It would break her for the rest of her life. I'm praying that dad gets accepted into your clinic and I'm praying that his insurance will cover it. If you see or hear the last name "Marsiglia ' when my contacts your clinic please please please accept him into your program.