Pathology and life topics aimed to foster a new generation of diagnostic pathologists skilled to care for their patients. Focused on morphology, surgical pathology and related issues. Comments and materials presented do not constitute medical advice, nor are they intended to provide care in specific instances.
hello sir my Father diagnosed with this cancer and surgery (whipple) is completed now doctor saying chemotherapy or radiation also going to treatment. Will my father get well sir? plzz reply
Hello doc I was diagnosed with signet ring cell carcinoma esophageal mild to moderate How serious is this cancer and what are advance treatments available please tell i am from india
Signet ring cells occur in cancers at several sites, including the esophagus. Generally these tumors are not a favorable diagnosis, but there are several variables, the most important of which are the stage (depth of invasion, any nodal spread, distant metastasis, etc.) and the precise molecular profile. There are several different groups of molecular changes that can be seen with this morphologic subtype of tumor. In our institution, tumors that are still T1a will be treated with endoscopic resection, but any tumor that is stage T1b to T3 will get some type of adjuvant treatment (drugs plus radiation) followed by consideration of a resection procedure. Tumors that are T4 may get targeted treatment depending on whether they express Her2, or standard chemotherapy. I hope that is helpful, and wish you a favorable outcome with this challenging disease.
MICROSCOPIC APPEARANCE: Sections revealed fragments of squamous and columnar lined mucosa. One of the fragment in the stroma beneath shows discrete atypical cells some are of signet ring cell type having vacuolated cytoplasm vesicular nuclei and mild to moderate nuclear atypia. Associated inflammatory cell infiltrates present. Remaining fragments shows normal mucosal lining with inflammatory changes. No extracellular mucin present. No intestinal metaplasia is seen.
Interesting question-- stress does impact many body systems, including the immune system, which plays a role in tumor detection and suppression. So probably yes-- but the timing of the stress, the type, etc. and the eventual appearance of a tumor may be quite difficult to connect since the time from earliest appearance of an abnormal cell to the appearance of a clinically detectable tumor is often many years.
My father has stage 4 lymphoma in his bone marrow. He said he could live another 10 years. He said he could die of something else entirely. I’m not buying it.
It depends a lot on what "flavor" of lymphoma he has. Some are rapidly growing, aggressive and hard to treat. Others are slower, indolent (and also hard to treat.)
@@LewisHassell-OPEN he says it’s terminal, in that there is no cure, but it’s non aggressive. His white blood cells were 11.8 and there was cloning going on. That’s what triggered the testing. The doctor told him to try to stay calm and not get upset because stress could increase WBC. They aren’t doing chemotherapy because you can’t do it on bone, he said. They didn’t see much in the cat scan. I’m just going to appreciate the time I have left with him and hope for the best. He’s very active for a 70 year old.
For cancer patient who has bilateral serous borderline tumor, microscopic tumor deposits in omentum and peritoneal fluid has atypical cells, does chemo be helpful or hormonal therapy? As the tumors are er and pgr positive
Borderline tumors do not respond to conventional chemotherapy, so the side-effects outweigh any potential benefit. I'm not sure about hormonal therapy; it isn't used commonly in our institution, but might have value. check with your gynecologic-oncologist
I've been diagnosed with the rare congenital GH in the duodenum, esophagus, and colon. My symptoms are difficult to deal with daily 💔 What can I do to avoid flare ups of the symptoms?
Sorry to learn of your distress. I am not the right person to ask about symptoms that flare up, but I would imagine you must have a gastrointestinal doctor who could help you manage those.
Dear Sir. What subtype is this neoplasm. Is it pancreaticobiliary or intestinal type of IPMN. I always have difficulty with this sutyping. Any morphologic clues would be very useful.
A really lovely and encouraging video It really gave me good thoughts and methods for learning and getting better at pathology Since pathology is a really huge specialty that sometimes gets me frustrated, your video gave me motivation ❤❤
A better analogy would be of a reservoir nearly to the brim. It isn't going to cause a flood unless some next step occurs- a break in the dam, or a downpour that pushes it over the top. A cancer precursor is like that, a state that awaits some further genetic change before it can progress to become life threatening. That change may come sooner, later, or perhaps not at all.
@@LewisHassell-OPEN so why wouldn't the EMT want to cut or freeze or Lazer it out they just want to wait till it becomes cancer shouldn't they want to get it early before the change?
my oncologist is going to schedule me to OU cancer center for treating SMARCB1-deficent sinonasal carcinoma. I am one of what like 200 cases like mine globally. and this is my 2nd carcinoma cancer. i was in 8th grade back in 1990 with Kemo and radiation (stage 4) . and tumor grew back after all these years and could be the heavy doses of radiation I had then. in May of 2024 this tumor was taken out and ready to hopefully soon get the treatment I need to again be cancer free!
This is a benign condition that doesn't require any surgery. The importance is for pathologists to recognize it and NOT call it something more serious leading to unnecessary surgery.
Thanks Dr. Hassell, showing a behing the scenes look is a great idea. Helpful for me but also something I will certainly share with my staff pathologists who are still figuring out how to integrate digital slides into their teaching presentations.
