At 62 I just reconnected with a family member who said the family is riddled with Fabry. I have been ill over 20 years and drs said I have CFS/ME but I always felt it was more. Now got to start the hard task of trying to get a genetic test with a dr that I cant even get an appointment with, times like this you really wish you had the money to pay privately but not been able to work for last 20 years. Symptoms got bad after 40. Dad died with heart failure and mom with strokes. Dads side is the carrier of the faulty gene.
My lipids are fine, cholesterol low. Fairly high calcium score and Lp(a). I couldn't think of anything to do but add colchicine 0.5. It's over the counter where I live. A doctor had me add aspirin, to my great unease. I also take an anti-hypertensive. With the low adverse profile of colchicine, I can't see a reason to not take it. I have no symptoms...yet. Stuck with something like Lp(a), which has no treatment, there isn't much useful intervention. I declined a tomography with dye because the only justification given was to decide whether to have a stent, and prior to a CV event I'm convinced (by cardiologists) that it's a bad bet. Office visits are normally concise. There should be some way that thoughtful patients and thoughtful doctors talk to each other (but not for treatment recommendations). It's sort of remarkable that no such forum exists.
Sir thanks for your priceless informative lecture you presented. May I ask how we made a balloon to be probably cutting for distal pressure measurement?
Excellent video. Covered all bases and and a great primer for new fellows starting cath. As someone who was trained in the radial first doctrine I must say your video is quite comprehensive! Great job
if my LPa is 486nmol/L (which it is) and my apo B was 160mg/dL = 2909nmol/L. Is this correct? and does that mean that one out of 6 of my LDL is the LPa type?
It is all in circulation or also in the heart if a person receives a new heart transplant could it also be there. I would imagine only in the circulation
Thanks a lot for sharing this content! The infromation presented here is inavuable for us people with hyper-lp(a)-aemia, for making informed decisions about our health and medical interventions. Especialy when official recommedations are obviously lagging the science.
Such a great man, Dr. Moses. He worked on my dad when every other doctor said stuff like "oh we'll adjust his meds and he will be alright". He saved my dad.
I'm in the UK and will be having this procedure 30th Nov 23. I have had issues with the heart since 2008 including heart bypasses. At the moment I can't do anything under pressure I have a angina attack. I'm scared about having this it's most probably the fact it's done through the main vein in the neck. I had stents through the groin. Can someone put my mind to rest a little please.
Great feedback discussion. I also support the view that hsCRP >2 should NOT be used to select patients who would benefit from colchicine for all the reasons you mentioned. Further, it would exclude its use in almost 2/3rds or patients with chronic coronary disease who have the same atherosclerotic process as those with a lower hsCRP at baseline and have a life time risk from their disease. While hsCRP is sensitive to risk in a cohort, it lacks specificity when assessing individual risk. To not prescribe colchicine in patients with proven coronary disease would be akin to not prescribing a statin in patients with a low LDL. Lowering LDLc and dampening inflammation are 2 sides of the same coin and both must targeted. Besides, 0.5mg of colchicine is safe, with a low risk of drug-drug interactions in patients without renal disease, and inexpensive (outside the US).
My (new) cardiologist will not prescribe Colchicine for me. The dr I had practiced preventative medicine and he was “let go”. I am that patient you describe & I am confounded by this Drs actions and words, I am in the process of finding a new doctor. Ps.. I don’t have renal disease nor kidney issues.
@radiant2012 Colchicine is OTC in Mexico. About 10 cents a day. I'm taking it after a 317 cardiac score. My lipids are fine, so no statin. No kidney issues. No improvement in all cause mortality is not great. Why focus on relative risk?
I believe the Slide on Topiramate is wrong at the 32:10, Topiramate enhances GABA (A) receptor activity, which inhibits the AMPA and kainate subtypes of glutamate receptors. The Slide states the opposite. Topiramate is an anti seizure drug, activating the Glutatmate pathway ould trigger seizures.
High blood pressure is the symptom for a medical problem. Artificially lowering blood pressure with drugs does not treat the "root cause" .While medication can control blood pressure, it cannot cure the condition.
😮 my aunt was Diagnosed with it and died at 55 from Liver Cancer. My Dad shows symptoms as well and has major issues. I have red Spots and Kidney issues. I just researched up testing centers.
