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So if hydration does correlate with stability, your latest model should be able to detect a change in Tm with increasing sucrose, right? Have you observed this?
For me the biggest advantage I see in the automation of the process (you can load about 48 samples) and the simplicity of using the system (for CD mostly you need a deeper education level). This is something, that is missing on CD. On the other hand, the user needs to know the purpose of using the system. The sence is for those labs who wants fast, accurate results for bigger amount of biomolecules such as proteins without complicated training and running system costs. Do you have any experiences with MMS or CD?
I think if it is doing real time buffer subtraction in that cell then they can basically avoid the buffer interferences you usually get in CD. So sulfate, phosphate, acetate buffers etc shouldn’t be a problem. Sometimes that can lead to big headaches with CD.
