Years of biology learning in the 80’s and I learned and understand more from this 7 min video. I hope colleges today use this kind of material, if they do the students are lucky.
Когда понимаешь, как много таких процессов происходит в каждой клетке каждую секунду не прекращаясь - становится даже удивительно, что в организме происходит так мало сбоев.
Very interesting video. It's unbelievable how perfectly these little machines work and how they are optimally co-ordinated throughout the entire organism.
Тяжело поверить, что жизнь на Земле зародилась самостоятельно. А если не самостоятельно, то как зародилась где-то та жизнь, которая породила жизнь здесь, на Земле?!
From the looks of all WEHI movies, it seems thermal movement (brownian motion?) is absolutely required for the molecular machines to work. I would love to see a video on how fever favors immune response, how a freezer slows down bacterial growth, etc.
They don’t show how the mechanism works here, molecular motors usually work via ATP or GTP working like switches and energy to a precise motion mechanism, a good example of the motion motor of kinesins is here, see how each ATP molecule gives its one shot spring energy to the motion structure of each foot to perform a single step along the microtubule… ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-YAva4g3Pk6k.html more details here about motor proteins and all their functions… (same kinesin in after 12 min…) ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-lVwKiWSu8XE.html Here instead the building mechanism of COP 2 the working scaffold forming vesicles, with similar GTP switches around 39s and 1m40s involved in the assembly or disassembly function… ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-ABGlD1vQG3s.html Biology videos don’t show all times these energy switches and the underlying motion mechanism, when their main purpose is to illustrate the whole working process of an enzyme, motor, or whatever…
They don’t show how the mechanism works here, molecular motors usually work via ATP or GTP working like switches and energy to a precise motion mechanism, a good example of the motion motor of kinesins is here, see how each ATP molecule gives its one shot spring energy to the motion structure of each foot to perform a single step along the microtubule… ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-YAva4g3Pk6k.html more details here about motor proteins and all their functions… (same kinesin after 12 min…) ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-lVwKiWSu8XE.html
@car103d You're right. I was talking about the stochastic movements, how proteins are brought to the mouth of the machine and other useful actions solely done by the brownian motion
@@spolo123 Yes the motion of water molecules (not shown) is crucial to the functioning of life, helping to fold proteins (hydrogen bonds forming hydrophilic bonds for protein folding and reactions) and enabling proteins and other molecules to react together. Too hot or cold and proteins unfold or chemical reactions are slowed.
@@spolo123 Ok, the warm environment and Brownian motion allow those mechanisms and the 'flow of life' inside the cell. There are more mechanisms than are commonly shown, who knows how many yet to be discovered, and many things that we once thought were accomplished by Brownian motion or other simple chemical processes, osmosis, fractal-like structures, etc. proved to be functional mechanisms. Another example is the formation of vesicles with COP 1-2, in my past I thought that those bubbles were formed by sprouting from the endoplasmic reticulum like soap bubbles on a surface of soapy water with a strong wind blowing above, or like bubbles of mud around hot springs or volcanoes, or in other similar ways. The following video shows how the COP 2 dynamic scaffold is capable of forming vesicles, also with GTP switches (at 39s and 1m40s) involved in the assembly-disassembly function... ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-ABGlD1vQG3s.html Biology videos rarely show these switches and the underlying mechanism, often even more mechanisms are omitted when the main purpose is to illustrate the bigger picture of the function e.g. of an enzyme, sometimes however I found interesting videos, like this one on how the MVP Major Vault Protein is built… How it is built in the cell, animation… ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-rqfbK2T03cA.html MVP Major Vault Protein structure www.rcsb.org/3d-view/ngl/4v60 Try switching the viewer, selector on the right [mol* (WebGL), NGL (WebGL), etc… ] if one doesn’t work on your device. Then choose different Style, Cartoon, etc.
I remember being curious about Molecular Nanotechnology in the 1990s (now called Atomically-Precise Manufacturing,) and we DREAMED of having simulations of our Diamandoid dreams like this!
Are there any mechanism that ensures ADP is always brought in to the reaction sites instead of another molecule? Are there like microtubules that picks out the right molecules into them?
The mechanism is protein structure itself, something like a lock -key principle. Protein is the lock,and ADP is key. Unique lock that can be only opened by unique key. Wrong key just wouldn't fit in the lock.
@@demonfedor3748 agree but in the lock-and-key analogy, someone has to bring the key inside the lock for it to work. At the cellular level, there are moles upon moles of other molecules present in the surrounding media, so what does it takes and what ensures that there is ALWAYS an ADP to insert into the protein? Is it always guaranteed that for every turn of the machine there is always ADP-ATP conversion? Or is it a hit-or-miss thing, by chance, like one turn could be an empty run?
Billions of years are not enough for some random events to create things this complex. It just shows how truly almighty the God is and how tremendously ignorant atheists are
This really feels like time is not linear... if cells can process so many things in 24 hours as a living being, then I can say I live more than a million times the life of a cell ...so like gods... Are we perhaps cells from a universe?
