Al-Hussaini Virtual Lab aims at addressing practical tips, pitfalls and challenges for the practicing pathologists that helps in drawing the avoiding errors or address new reporting skills
Hello dear. Thank you for sharing the case. Without molecular classification you cannot it call it as such especially that supportive features including the loss of ATRX are not seen. You can call it high grade glioma, consistent with glioblastoma NOS.
Dear prof , i have a problematic case 5yrs , deep frontal ( with a midline component yet the radio is suggesting that the epicenter is not midline) , Histo: looks glial with atypia , bizzare cells , mitotic activity , microvascular proliferation IHC : GFAp: patchy positive Olig2 ; diffuse positive Ki67: around 25% Neurofilment: some fragments are negative other tumor areas are positive H3kme3: loss INi: retained Synato; patchy EMA; negative IDH: non mutant P53: non mutant BRaF: negative CD34: negative Its a def. High grade glioma yet i need to push towards somewhere can it be a HGG with piloid features although i have no rosenthal or EGBs or ATRX or molecular
This is a tumor with an undetermined malignant potential. It should be regarded as a borderline tumor that needs close follow up but no active treatment.
If we don't have POLE mulecular study, can we still write the 2023 FIGO stage in our diagnosis? For example an aggressive histologic type or tumor with invasion of cervical stroma should it be staged as FIGO II before doing the POLE molecular test? And if subsequently, the molecular test shows POLE mutation, should we downstage it to FIGO IAm (POLEmut)?
