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Hi, endothelin-1 indeed plays crucial role in initial vasoconstrictor (reversible), which is the central factor contributing to development of pulmonary arterial hypertension. (we have drug Bosentan which blocks ET-1 receptor - for PAH) But in terms of tissue remodeling and fibrosis myofibroblasts is the major factor. Fibrosis cause irreversible vasoconstriction. Do endothelial cells produce TGF-beta - yes. But are they the major producers of TGF-beta - no. So in terms of ET-1 and pathogenesis of early stages of vasoconstriction - you are correct. In this video i made an accent on fibrosis and sclerosis (cause it's scleroderma) and the role of immune cells ( cause in treatment we use MTX and other immunosuppressive agents), but when i will remake this video at some point, adding new features, i will definitely add the role of ET-1.

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Thanks for watching. Wacom intuos pro m + autodesk sketchbook.

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You welcome, 3rd degree av block ecg criteria: when there are no evidence of AV conduction p waves are not related to qrs 1.Ventricles paced by ventricular pacemaker, 2. atria by sinus, rate of ventricles (RR intervals are used for calculation ) always lower than atrial (PP intervals are used) Heart attack is a synonym for myocardial infarction ecg criteria st elevation/ depression pathological Q wave We have another video about AV block, hope it is helps)

@@Foxterrier ah I understand the difference now thank you so much, super helpful ! Great I will check your other videos, as a student I really appreciate these videos 👍🏻

@Kim-kd8or hope you will enjoy)

Because of that buspirone lowers serotonin in synapse and enchanche sexual function, in combination of ssri, or alone... Womens with hipoactive sexual funciotion, give a augment in sexual function, because dopamin its raise indirectly, serotonin inibits dopamine because the activation 5HT2C receptors in dopaminergic neurons, on tegmental ventral area

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Hi, thank you very much. It’s a pleasure to hear that. I always make videos based on what interests me at the moment. Right now, I’m working on a video about Ozempic for weight loss, as well as a few on biochemistry. At some point, I’ll also make one about monoclonal gammopathy of renal significance. Thanks for watching )

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No, i record vid and audio separately )

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