Bonjour Diane, I've tried to contact you by email. I would like to know how I can PAY for a consultation with you (via email) in order to get some answers. My cat is FECV and I would like to know if it is safe to give him: - Dewormer (oral medication) - Pancreatic enzyme supplements - Elura ("Owners should be advised that ELURA mimics the action of a naturally-occurring hormone called ghrelin. Ghrelin influences many systems in the body. ELURA may also affect these systems. Owners should monitor for changes in: thirst or water intake; lethargy or weakness; digestive issues (vomiting, diarrhea, drooling, decreased appetite); or behaviors.) - Supplements to boost immune system (e.g. Fortiboost paste by Osalia) I've been holding on the deworming treatment for more than a year now so I really need to know if it is safe or not. Please help me! Claire from France
Bonjour Diane, I've tried to contact you by email. I would like to know how I can PAY for a consultation with you (via email) in order to finaly get some answers. My cat is FECV and I would like to know if it is safe to give him: - Dewormer (oral medication) - Pancreatic enzyme supplements - Elura ("Owners should be advised that ELURA mimics the action of a naturally-occurring hormone called ghrelin. Ghrelin influences many systems in the body. ELURA may also affect these systems. Owners should monitor for changes in: thirst or water intake; lethargy or weakness; digestive issues (vomiting, diarrhea, drooling, decreased appetite); or behaviors.) - Supplements to boost immune system (e.g. Fortiboost paste by Osalia) I've been holding on the deworming treatment for more than a year now so I really need to know if it is safe or not. Please help me! Claire from France
Dear Dr Diane and team, my boy Pumpkin is back to his normal self since early this year after following your kind instructions. He was diagnosed with wet FIP last December. We gave him a jab and switched to oral after watching your video and reading papers on your website. The other two cats also had a week of double dose together with pumpkin towards the end of the course as advised. Thank you very very very much for making this information available to all. It saves life and money! Love from Malaysia ❤
Hi Dr. Diane, I have a 10 months old male Devon Rex diagnosed wet FIP. My doctor immediately prescribe him Bova pills 50mg for the next 84 days. Can you share if you know any ratio on a success rate of this pill? Where I’m from people do not support pill treatment but injections 😢 because those 441 groups says the survival rate is higher.
I need your help. I am trying your protocol with 20mg/Kg for neurological FIP. should I divide the dose into 2, morning and evening? should I keep the same dose throughout the treatment or can I reduce the dose at some point? I m from France.
hi dr! Just wanted to ask what you think of favipiravir as an option for FIP treatment since it was similar to molnupiravir? I was looking for options and I saw that compared to other treatment, favipiravir lacked clinical studies. Even paxlovid seems to have few studies compared fo favipiravir. Is it perhaps has more risks of side effects compared to other meds?
hi dr, I started molnupiravir treatment for my cat and its been one week into the treatment. He thankfully gained weighed, my vet also said he needs a minimum of 5 weeks treatment, if by then the virus went back to sleep, we can stop the treatment and hopefully no relapse. I was told to keep my cat stress free to prevent relapse 😊
I'm glad that is working for your cat. What we found was that each cat needed to be treated as an individual: some needing a longer course, some shorter and monitor blood results to know when to stop treatment safely. It's important to begin with a double dose for about 2 weeks to ensure you clear the brain of virus. Remember also to check your other cats for virus shedding and clear them with a 5-7 day course of pills to prevent re-infection of the FIP patient. God bless you and your cats. D.
Hi Dr. Diane, I would like to set up a consult with you. I am currently treating my cat with FIP and he has had some complications late into treatment and I now on an extremely high dose. Any help would be greatly appreciated.
My cat started on injections in January but quickly moved over to pills after about 3 weeks in. On day 79 of his treatment he got very sick and was showing signs of a regression. Our team believe it was another virus or infection though because it was SO late into treatment. Out of precaution they made us change over to injections again on a very high dose. That is what we are currently doing and he has gotten better for the time being. We are seeing a specialist next week to get a better idea of what happened but do you have any opinion on this?
So GS 441524 is also attacking FCoV, not only mutated FIP? My cat has dry ocular FIP and is currently on day 12/84. First 7 days she was on injections 10mg/kg, after that we switched to piils. She is great but her stool is still not great. It was worse before it became better since switching to pills. (She had loose/watery stool since she came to me in late january) I was afraid it was from pills but your video gives me hope it will resolve in a few days.
Dear Iva, diarrhoea is not a typical FIP symptom. It can happen due to inflammation in the intestines, but it should resolve within a few days after the start of the treatment. If loose stools continue, you should take a standard approach and start with complete stool testing, in some laboratories, it is called “diarrhoea profile” i.e.: IDEXX Canine and Feline Diarrhea RealPCR Panels, to determine the cause of diarrhoea.
@@dominikmirowski4390 no, she had diarrhea prior to developing fip symptoms. She also had inflamed gums and was smaller for her age. Her stool was tested for parasites and giardia and came back negative. She is now little over 5 months old. We resolved all of the issues except diarrhea when her FIP symptoms showed. Now she is actually doing great. Her stool is getting better every time. Now I have a feeling it is because of the gs pills after watching this video.
Thank you for sharing your experience. Please let us all know if your cat's diarrhoea resolves after about 12 to 14 days on the GS-441524 pills. As I showed in another video, beginning with an antiviral injection can risk mutants developing in the gut which resist the antiviral drugs, so if your cat persists with a loose stool, it may be a sign of needing to change antiviral, but hopefully that won't happen. God bless you and your cat.
@@DrDianeDAddie Thank you for the response. She seems to have better stool with each time. Today she unfortunately showed signs of anisocoria again but it lasted about two hours. Now she is normal again. The admin told me to up her dosage to 15mg/kg pills. Told me not to worry. Fingers crossed.
Reading this publication: "An Optimized Bioassay for Screening Combined Anticoronaviral Compounds for Efficacy against Feline Infectious Peritonitis Virus with Pharmacokinetic Analyses of GS-441524, Remdesivir, and Molnupiravir in Cats" I noticed that the peak plasmatic concentration of gs441524 detected with oral administration is different compared to the injectable one. "Peak plasmatic concentrations of GS-441524 were > 30 µM after oral administration of GS-441524 at 25 mg/kg with no treatment-related adverse events; this is approximately 3-fold higher than the Cmax when GS-441524 is subcutaneously administered at the 5 mg/kg (~10 µM)." Should a FIP cat who started therapy with injectable according to these data be increased 1,6 x when switched to tablets? best regards
What an EXCELLENT question! That's the Cook paper, isn't it? I'm planning on doing a brief video to explain a little about using remdesivir orally rather than by injection (Cosaro et al, 2023 have shown that it is effective against FIP orally so there is really no reason to inject it, although of course it's less effective than GS-441524 because the body has to convert remdesivir to GS-441524). In a way, the simple answer to your question could be "yes", but it becomes more complicated when you take into account that analyses of various oral products showed that they contain rather more GS-441524 than they claim to: in other words the manufacturers have already taken into account that the drug is less bioavailable when given orally, so there is a risk of overdosing (risk of bladder stones and possibly kidney damage). If you would like to friend me on MeWe we could discuss the specific product(s) you have in mind: my MeWe address is www.mewe.com/i/catvirus1. Another thing to think about is using a double dose of antiviral to clear the brain of FCoV, but again, one would only do that briefly (about 2 weeks) unless the cat were exhibiting neurological FIP. We are fortunate in the UK in having a Bova pill and potion where the stated amount in is is what is really in it. My recommended dose for such products is 20mg/kg for two weeks dropping to 10mg/kg until the acute phase protein AGP has consistently returned to normal values (I believe SAA could similarly be used but have no evidence, whereas I've published the AGP evidence). Thank you for such an erudite question. God bless you and your cats, D. Addie
@@DrDianeDAddie thank you for your kind reply, I had read the recent publication by M.Kent et al where they found important differences in active ingredient content compared to the values declared by the manufacturer (with an average of over 20% in excess). The problem is that some products were found to be much underdosed compared to the declared ones such as Capella and Curefip in the more concentrated formats. Others, however, correspond almost perfectly to the values declared by the manufacturers. I hope that these studies help to clarify until the Italian drug agency authorizes the distribution of products similar to Bova Uk. I've already followed your MeWe page, thanks again for your availability! Giovanni
My cat is five years old. He was diagnosed with fip in September last year and is being treated using a gs 441524 drug. The pleural fluid does not disappear. It was confirmed through ct imaging, ultrasound, and blood tests that it was not a different disease. However, even with long-term drug treatment, pleural effusion does not disappear. Tachypnea and pleural effusion were his first symptoms. Coronavirus was detected in the pcr test that was performed with a pleural puncture. Could he be suffering from another disease? Or ask for advice on how to treat it
Hello, I live in Vegas. I have a Neuro relapse cat. I am treating this time with GS capsules. It’s been a month and he’s still not walking. Seeking some info and found your channel
I'm really sorry to hear this. Have you tried molnupiravir? If you've tried double dose (i.e. 20mg/kg GS) by mouth and it hasn't worked, then try molnupiravir. Supplement with vitamin B12.
>>>>PLEASE RESPOND<<<< I would much prefer doing the pills as the injections are not a good experience for me or my cat ...but. He has diarrhea and I have been advised that the pills are not effective in this case. I have him on probiotics but so far his diarrhea has only improved a little. Do you still think the pills would would be best for him?
Yes I do, and would likely stop the diarrhoea, which is also probably caused by the coronavirus. Please give it a try and let us all know how you get on. God bless you and your cat.
Hello! Our kitty was diagnosed with dry/neurological FIP in the end of December. Now it is our 41st day of treatment, we are doing 12mg/kg dosage injections. Also, we were giving him Prednisolone until 15th day of treatment. Now we would like to switch to pills. I wanted to ask if there is still something we can do to prevent possible relapse? Thank you!
Yes, change to pills as soon as possible and increase the dose to 20mg/kg. Prednisolone is a disaster and inhibits recovery. If your cat does relapse at least there's the chance to use molnupiravir, which has rescued a number of FIP relapses.
i have a 5 month old kitten that the vet said has FIP. He had his first injection last night and this morning he was foaming from the mouth, rapid breathing, rapid heart rate, and would not shut his eyes. He is still the same if not worse now and i don’t know what to do with him.
@parisarnett1638 I'm sorry to take so long to reply. Please switch to GS-441524 or molnupiravir (EIDD) pills. I think you need to take him back to your vet. I am so sorry for you and your cat to be going through this.
You are such a godsend. We sent you an email regarding Nirmatrelvir and Ritonavir pills as another optiom for treament. Is this viable?? We would love to hear from you!! Many thanks!!
Hello! My cat Mitze is 1 year and 2 months old and she was diagnosed with wet FIP in december. She has already taken 32 injectable doses of GS and still haven't improved. We sent the abdomen liquid for analysis and they found the virus in it. She has granulomas in her liver and spleen shown by the ultrasound. She has very little appetite and just lies in bed all day and she's losing weight. We've drained the liquid from her abdomen twice and it's already swelling up again. We really don't know what to do. Do you think we should switch the GS supplier? Should we talk to the veterinarian about the possibility of giving Mitzi antibiotics?
Please ask your veterinarian about switching to molnupiravir PILLS - not injections (see my videos on why injections are not as good as pills. Please let us know how you get on. I will pray for Mitze and hope others will pray for her recovery too.
@@DrDianeDAddie Hello there, just an update: we tried switching the GS brand but it didn't work...I believe she is resistant to the GS. We will start giving her Molnupiravir pills. Does that work on these cases? We are truly desperate.
Supplement the GS with albumin capsules, liver supplement containing sylmarin and in case your cat has anemia symptom it will need B12 injection as well.
I had to put my 10 year old cat down due to FIP, he started to lose hair and become more anxious and the blood work looked fine in may but by november he had lost weight and was tested again and we found he had supposed liver failure, small kidneys and fluid was building up in his stomach and check to the point it had enlarged his body and become visible on the outside. His body started reacting to it like an allergic reaction as he began to get flakey skin and lose hair. Im so worried my other cat may have it due to litter sharing, the vet never mentioned it could be contracted this way and I wish I had thought of it sooner.
That's a great question because of course in nature, cats would be eating meat raw! You'd expect the shape of L-arginine to be changed by heating, yet most papers which examined the effect of cooking on nutrition do not report an adverse effect from cooking. I suppose cats would be dying everywhere if food processing had destroyed the arginine. Many thanks for making me think about that! God bless you and your cats.
Hey, I have just started my treatment with my sweet Chunky, I took him in for a teeth cleaning where my vet ended up extracting all his teeth. After the surgery my cat was fine until the second week when I started noticing a constant fever. I took him him for a recheck and his blood work was all wrong as well as one eye was a different color. Long story shoe he got ocular FIP 😢 I have already started the injections but I really want to start the pills (I already ordered some) as of day one he seems to be himself again 🩷 I am very confused on understanding how much he needs to take. Chunky is weighing 12lbs how many pills would he need to take ? Thank you!!
I'm really sorry that I didn't notice your comment until now. How is Chunky doing? The dose you use will depend on which brand of pills you got. My email is draddie@catvirus.com if you have more questions.
My kitten Brandy, she was 8 months old, had to be unthanazed today. She was sprayed a week ago and she didn't like the collar around her neck so I took it off. The stitches became infected because the vet said I let her lick it. Is her death my fault? I'm distraught. She had peritonitis. The vet said she got it from licking her stitches.Xx
I am REALLY sorry to hear this awful story and ashamed that a member of my profession, a vet, would put the blame on you. This was NOT your fault. There is no way your kitten got peritonitis from licking her stitches. I send you my deepest sympathies.
Hello! My 3yo cat had a fever for 2weeks. She lost weight very fast. We gave prednisolon, antibiotics and melosus (for pain and fever) but she didn‘t get better. Well, at least she was eating again. The bloodwork came back with changed ig, albumine, but negative for fcov. Vet said it must be sepsis. Then her abdomen got larger and larger with ascites, a new test was negative for fcov again. The laboratory said it might be because all the antibodys IN BLOOD are bound to antigen?! So fip but just low antibody count. We started sc treatment 3 days ago and i am so worried its the wrong diagnosis. Now Theos story sounds so similar… please, what do you think?
I'm very sorry not to have noticed your comment before now. The antibody binding to antigen problem is more likely if effusion, rather than blood, was put onto the test. What happened to your cat? I hope that they sent off the effusion for analysis to determine the reason, or at least narrow down the list of differential diagnoses?
@DrDianeDAddie Thank you for your response! Sadly my cat died. I called and cancelled all lab tests the day after her death. I will never know what she was suffering of, probably not fip. We treated her with GS for 5 days. The feaver was gone but ascites increased even more. The fluid was yellow and cloudy but not putride (it didn't smell).
Thank you very much for these videos re Lysine. My cat (male · 5 months) was diagnosed with calicivirus, FIV and gingivostomatitis and was prescribed Lysine. I looked for information about this supplement and I found the paper written by Bol S and Bunnik EM. I am no expert, just a worried pet owner looking for answers, so I kept on giving it to my cat. Now, after what you just explained, I am going to talk with my vet because I want to discontinue its administration. I have read about bovine colostrum for immune support (Gore AM, Satyaraj E, Labuda J, Engler R, Sun P, Kerr W, Conboy-Schmidt L. Supplementation of Diets With Bovine Colostrum Influences Immune and Gut Function in Kittens. Front Vet Sci. 2021 Aug 10;8:675712. doi: 10.3389/fvets.2021.675712. PMID: 34447799; PMCID: PMC8383104), so maybe I should try it instead of Lysine. Once again, thank you very much for your dedication.
THANK YOU for your comment. I'm really sorry to hear about your cat and hope your vet will be open to trying alternative treatments. Do NOT use corticosteroids. Please friend me on MeWe to join my FGS group if you would like to: www.mewe.com/i/catvirus1 and ask your vet to join too. Please subscribe to this RU-vid channel and my Bitchute channel (for content YT would censor).
Hi Diane, thank you for putting this information out there. I was hoping you could answer a few questions for me. My cat's spinal fluid was tested for FIP, the results were 10 mRNA copies per sample (not sure if that is helpful to you) and my vet said it is extremely unlikely that the test could produce a false positive. My cat's symptoms are very mild compared to other stories I have seen. It's been about a week since his first neuro episode; he was walking hunched over with his tail between his legs for 2 few days, but after that his posture went back to normal. He has refused food once since his diagnosis (very unlike him) and has been vomiting clear liquid occasionally (1x a day at most) with some mild GI upset (runny poop). My question is, can a cat have FIP and not have severe symptoms or for the symptoms to not present for days or weeks? My vet was shocked that the test was positive, but still suggested I treat him just in case.
I also wanted to see what dosage you may recommend for a cat who is 11.5 pounds? The company I ordered the GS pills from is recommending 12mg per 2.2 lbs of body weight per day
I agree with your vet about treating him to be on the safe side, but I would like to know more, both about the test and which treatment you are using. Would you contact me on draddie [at] catvirus.com? Non-effusive FIP can indeed incubate for a long time - even many months.
Thank you and I'm sorry to take so long to reply. My ABCD colleague Dr Hartmann has just had great success using 15mg/kg for 6 weeks. I've been using 20mg/kg for the first 2 weeks of non-neurological cases, to clear the brain. However, there is a risk of bladder stones, so I am learning all the time and changing my recommendations as we gather more data worldwide. Also remember that pills sold online can have varying amounts of GS-441524 in them. Please watch my FIP Treatment page on www.catvirus.com to get the latest information. @@emmafrisbie6611
Hi, is it possible to stop treatment before the 84 days or is 84 days absolutely necessary? My cat has wet FIP and appears to be back to normal, i've done 50+ days of treatment so far with oral GS but I'm running out of funds for the next batch of pills...
We showed that 84 days is not usually necessary: please show our paper to your veterinary surgeon and ask for the AGP blood test that determines whether your cat is truly cured or only in remission. The paper is here: www.mdpi.com/1999-4915/14/4/744/htm# If you copy that link and paste it the paper should come up.
Hey I have a cat we cured from FIP. Another cat of ours got out and never came home. Roommate adopted a cat he thought was ours but when we got him home it was very obviously not him. Unfortunately shelters don't allow much interaction. The cat he adopted has FIV but I'm now worried he has contracted FIP from the cat who previously had it. I know FIP itself isn't contagious but the virus that causes it still is. So I guess my question is how do I find out? I can't afford heavy vet bills. Just lost both my jobs unfortunately. He certainly has a URI. The cat we cured of FIP has had a URI on and off for a few months. We believe it to be his dormant coronavirus. I believe the FIV kitty has contracted it that way as we have recently started letting him out of my room since he was crying so often. Please help its urgent. I'm taking him to vet in morning.
Pleasd give a site to buy GS-441524 MY CAT HAS a dry pif (fip) i'm scared that someone will give a fake medicine or something that hearts my baby . Please i wanna something safe for him tell me where to buy this medicine or give me the best market of it .
Please email me on draddie [at] catvirus.com I'm sorry to hear about your cat and that I didn't notice your comment sooner. God bless you and your cat.
Hi Dr Diane, I would like to consult with you via your website and am hoping you have some spaces? our 6 month old Ragdoll is currently undergoing treatment, she was given injections of Remdesivir for about 3 days (I’m not sure of the dosage but will find out) and she has been on pills from this Monday of 20mg (7 days of treatment so far). Currently there is not much improvement, nor have her bloods changed since she has started the treatment. They are now going to up the dosage of the pills to 30mg . She is presumed to have dry FIP, she has neurological signs, can hardly stand and as of the other day is starting to have seizures. I’m based in the UK and would really appreciate your advice, thank you
I am so sorry to hear this and I am also sorry that I haven't seen your comment before now. Email me at draddie@catvirus.com for advice. Is she on Bova GS-441524 pills? At 30 mg per kg? I hope I'm not too late.
dra Addie, i need to talk to you?. I am veterinrian here in Brazil, with a patient with FELV and Fiv and gengivostomatitis.. i saw the article using Thalidomide, and I want know if you used this medication also in retroviroses postives.. tks a lot. And tks for all the knowledge and articles to support cats diseases.. i have treated lot cats with gs and found some articles and the catvirus site information very useful ! You are an angel 🙏
I would like to just point out that it is RU-vid and not me who has put advertisements on my video. I have no control over that - they don't give me the ability to prevent ads.
Hi! Thank you for the informative video. I’ve been wanting to start treatment with my 10 month old cat who was just diagnosed with FIP. She started showing symptoms (pleural effusion) a few days after her fist vaccine dose, which I believe was the stress factor that lead to the mutation. I was going to get started with injections but after watching the video I’ll go with the pills. The one that I have access to has 45mg of GS in 1 pill. Is that an enough amount in a dose? They suggest to start with the injection as they say the cats don’t absorb too much when on pills. I would appreciate your input.
Also, they say that if the cat has a neurological form of FIP the dose should be higher. I know hers is wet (because of the effusion) but about 1 month ago she had an episode that seemed like an eye infection (I though she was going blind as she couldn’t see properly) but I believe she fully recovered from that as her eyes are back to normal (I gave her medication). Is that possible with FIP? Does that mean she also has the neurological form?
I'm really sorry to take so long to respond to your comment. Can you tell me the brand of the pill you have access to? I actually believe that ALL FIP cases should begin treatment with a neurological level dose of GS-441524 or molnupiravir, which usually means a 20mg/kg dose. Please make certain about the diagnosis, especially if after a week of antiviral your cat isn't improving. God bless you and your cat! Diane@@NiicoleF
I agree: it was likely the vaccine stress which triggered FIP. I'm so sorry that you weren't advised to have a feline coronavirus antibody test before the vaccine, to check whether or not there was a risk of FIP. So sad you and your cat are going through this, but at least now it is curable.
@@DrDianeDAddieHi Dr Addie, thank you for your response! I chose to go with the pills, the one that I have access to here in my country (Brazil) is from CureFIP. I’m on day 50 of the treatment and she is almost healed! Her blood samples have improve dramatically and she showed signs of improvement after 2 days of taking the pills. I’m grateful for the information you shared. I read everything on your website. Thank you! I hope the info is spread so professionals don’t make the same mistakes they did with her that lead to the mutation in her body. She was also Felv positive at the time of the vaccination.
If the dose is high enough, the risk of relapse is lower, no matter pills or injections. 4mg/kg is way too low dose! We start treating the wet form on 8-10mg/kg, all others above 10. No relapses in 9 cats.
Well done! I agree completely: 4mg/kg is way too low especially at the start of FIP treatment. However, we have to bear in mind that Prof. Pedersen was wary of side effects, which was probably why he began with a cautious low dose. The literature on remdesivir shows that it is very toxic to kidneys, and he probably bore than in mind when working out how to cure cats of FIP. His study was a major breakthrough.
There are other reasons why I don't recommend injections if pilling is at all possible: they are very painful and inflammatory, which is a risk for feline injections site sarcoma, and people who used them reported to me that it destroyed their bond with their cat: the cat lost all trust in them for inflicting so much pain on them. I know there are ways of mitigating the pain, but why do GS injections unless pilling is absolutely impossible? Also, as I said in the film, they don't reliably prevent FCoV shedding in faeces, which puts other cats at risk.
