Neuromodulation approaches. We can determine the Neuromodulation as "An alteration or modulation of the corrupt nerve activity by electrical stimulation or chemical agents" The Neuromodulation is carried out to normalize or modulate nervous tissue function. Neuromodulation interventions consists of 5 different surgeries performed in different diseases. Deep Brain Stimulation for; Parkinson’s Disease Dystonia Essential Tremor Obsessive-Compulsive Disorder (OCD) Epilepsy Spinal Cord Stimulation for; Intractable Pain Diabetic Neuropathy Failed Back and Neck Surgery Buerger Disease Phantom Pain Ischemic Pain Sacral Stimulation for; Urinary Incontinence Urge incontinence Fecal Incontinence Interstitial Cystitis Overactive Bladder Urinary Retention Urinary Urgency-Frequency Vagal Stimulation for; Intractable Epilepsy Major Depression Episodic Cluster Headache Intrathecal Baclofen Pump for; Intractable Spasticity Intractable Pain.