The game is called struggle simulator

Effects Notes (except in Repentance) Brimstone is a special item. Character Azazel icon Azazel starts the game with a short-ranged, slower-charging version of Brimstone. Without the long-range version, his mini-brimstone won't have enough length to use any homing items. (except in Rebirth)His Brimstone's shorter range can be increased with range-increasing items or pills. Multi-shot effects like Collectible 20 20 icon 20/20 will increase the number of beams accordingly, with exceptions listed below. Although extremely unlikely, Isaac can shoot a total of 16 blood beams at a time via multi-shot items. If the number of blood beams would exceed this number, the beams' span will instead widen. (in Repentance) Character Tainted Azazel icon Tainted Azazel has a full-range, but thinner beam whose damage is halved unless enemies are cursed by his inherent Collectible Hemoptysis icon Hemoptysis sneeze. The beam will apply Tear effects and does so frequently thanks to its high tick rate. Any item that grants homing tears: will cause the beam to make sharp turns and even loops to hit enemies, which is extremely powerful. Character Azazel icon Azazel's mini-brimstone does not home unless he has a high range stat.

Synergies Interactions Overridden by Brimstone: (in Rebirth) Collectible 20 20 icon 20/20 Collectible Cursed Eye icon Cursed Eye (except in Rebirth) Collectible Evil Eye icon Evil Eye (in Afterbirth † and Repentance) Collectible Eye of Belial icon Eye of Belial (in Afterbirth and Afterbirth †) Collectible Explosivo icon Explosivo (in Afterbirth † and Repentance) Collectible Flat Stone icon Flat Stone (in Afterbirth and Afterbirth †) Collectible Head of the Keeper icon Head of the Keeper (in Afterbirth and Afterbirth †) Collectible Holy Light icon Holy Light (in Afterbirth †) Collectible Jacob's Ladder icon Jacob's Ladder (except in Rebirth) Collectible Kidney Stone icon Kidney Stone (in Afterbirth †) Collectible Lachryphagy icon Lachryphagy (in Afterbirth †) Collectible Lead Pencil icon Lead Pencil (in Rebirth) Collectible Monstro's Lung icon Monstro's Lung (in Rebirth) Collectible Mysterious Liquid icon Mysterious Liquid (in Repentance) Collectible Neptunus icon Neptunus (except in Repentance) Collectible The Parasite icon The Parasite (in Afterbirth † and Repentance) Collectible Parasitoid icon Parasitoid (in Afterbirth †) Collectible Pop! icon Pop! (except in Rebirth) Collectible Pupula Duplex icon Pupula Duplex (in Rebirth) Collectible Rubber Cement icon Rubber Cement (in Afterbirth †) Collectible Sinus Infection icon Sinus Infection (in Rebirth) Collectible Tech.5 icon Tech.5, unless using Character Azazel icon Azazel, in which case it will fire normally while charging Brimstone (in Rebirth) Collectible Technology icon Technology (in Afterbirth † and Repentance) Collectible Technology Zero icon Technology Zero (in Afterbirth † and Repentance) Collectible Trisagion icon Trisagion Only stat effects are applied; otherwise overridden by Brimstone: (in Afterbirth † and Repentance) Collectible Compound Fracture icon Compound Fracture (in Afterbirth and Afterbirth †) Collectible Continuum icon Continuum (except in Repentance) Collectible Cricket's Body icon Cricket's Body (in Afterbirth and Afterbirth †) Collectible Marked icon Marked (in Rebirth) Collectible My Reflection icon My Reflection (in Afterbirth †) Collectible Sulfuric Acid icon Sulfuric Acid (in Rebirth) Collectible Technology 2 icon Technology 2 Other interactions: (except in Rebirth) Collectible 8 Inch Nails icon 8 Inch Nails: Beams gain knockback, pushing enemies away in the direction they travel but not out of their path. This increases its consistency. (in Repentance) Collectible Abyss icon Abyss: When Isaac uses Abyss to absorb Brimstone, it turns into a larger gray locust, but otherwise acts like normal locusts created by Abyss. (in Repentance) Collectible Bird's Eye icon Bird's Eye: Will occasionally spawn a fire when firing. (except in Repentance) Collectible Chocolate Milk icon Chocolate Milk: Reduces Isaac's tear delay by 20%. Does not increase damage. (in Rebirth and Repentance) Collectible Dr. Fetus icon Dr. Fetus: Overrides Brimstone. (in Afterbirth and Afterbirth †) Isaac continuously fires bombs while charging the beam. (in Rebirth) Collectible Epic Fetus icon Epic Fetus: Overrides Brimstone. (except in Rebirth) Collectible Epiphora icon Epiphora: Effect only activates when holding charge in a specific direction, and deactivates when the charge is released, effectively making Epiphora useless unless Isaac has exceedingly high tear delay. Collectible Fire Mind icon Fire Mind: The beam will not cause explosions, but will still set enemies on fire. (in Afterbirth † and Repentance) Character The Forgotten icon The Forgotten: The charged attack will spawn a Brimstone ball that will float in front of The Forgotten for a few seconds before disappearing. The Forgotten will still melee attack while performing this action. (in Afterbirth †) Collectible Ghost Pepper icon Ghost Pepper: The flames can still shoot from Isaac while holding the fire button. (in Repentance) Has a chance to shoot flames for every other tick while the beam is being fired. Collectible Godhead icon Godhead: Homing and stat bonuses apply, but the beam does not have a damaging aura. (in Rebirth and Afterbirth) Collectible Ipecac icon Ipecac: Does not apply Ipecac's stat changes. The beam poisons enemies. (in Afterbirth †)Isaac shoots Ipecac tears while charging Brimstone. Stat changes from both items are applied as normal, meaning that Ipecac fires slower and Brimstone charges slower, but Brimstone deals drastically increased damage. (in Repentance)Applies +2 flat damage, instead of Ipecac's damage up. Does not apply Ipecac's tears down. The beam explodes on the first enemy or obstacle it hits every other tick, dealing 10 + twice of Isaac's Damage. The beam gains a poison effect. The explosions do not occur when the beam narrows, meaning that they occur only twice per shot without Collectible Soy Milk icon Soy Milk / Collectible Almond Milk icon Almond Milk. The beam and its explosions poison enemies. Collectible The Ladder icon The Ladder, when placed, will trigger the Ipecac-Brimstone explosions. (possibly a bug) Ipecac + Collectible Haemolacria icon Haemolacria: The flat damage bonus is +40 instead of +2. Tears will explode into multiple brimstone beams, each of which explodes and has a chance to hit Isaac. (in Rebirth and Afterbirth) Collectible Isaac's Tears icon Isaac's Tears: Fires normal tears, but nearly instantly charges when charging Brimstone. (in Afterbirth †)Fires normal tears. Charges at the same rate as Isaac's fire rate while charging Brimstone. (in Repentance)Fires normal tears. Charges when firing Brimstone. (in Repentance) Collectible Knockout Drops icon Knockout Drops: Gives the lasers high knockback. (in Repentance) Collectible Lachryphagy icon Lachryphagy: Brimstone's range is lowered, but Lachryphagy tears will form at the end of the beam, which can be fed. (in Afterbirth † and Repentance) Collectible Large Zit icon Large Zit: Creep shots will still be fired occasionally while holding the fire button. (in Repentance) Collectible Lodestone icon Lodestone: Changes the beam to gray, can still apply the magnetized effect. The beams are not attracted to enemies with the magnetized effect. Collectible Number One icon Number One: Although Number One is otherwise purely beneficial with standard Brimstone, Character Azazel icon Azazel's range is severely affected. (in Repentance) Collectible Playdough Cookie icon Playdough Cookie: Brimstone will start cycling through colors and applies the standard chance of tear-effect on hit, with the homing effect occurring intermittently. (in Repentance) Collectible Pop! icon Pop!: Brimstone has shorter range, a bit longer than the default range of Character Azazel icon Azazel's mini-Brimstone, and it is not affected by Range. The beam fires Pop! tears at the end, which are Piercing. (in Rebirth) Collectible Proptosis icon Proptosis: Does not apply distance penalty. (in Afterbirth and Afterbirth †)The beam deals 2× Isaac's Damage, which is already doubled from the item's effect, at point blank-range. The damage quickly drops further along the beam, at about 0.8× per tile of distance. (in Repentance)The beam deals 6× Isaac's Damage at point-blank range. Decreases 13.3% of the damage per tile of distance, to the minimum of 0.1 point of damage at 7.5 tiles of distance. (in Repentance) Collectible Spirit Sword icon Spirit Sword: Overrides Brimstone. (in Repentance) Character Tainted Samson icon Tainted Samson: Greatly decreases attack speed for Samson's rage mode melee attack and replaces the thrown jawbone with a large laser sphere (similarly to Character The Forgotten icon The Forgotten).

Synergies Interactions Overridden by Brimstone: (in Rebirth) Collectible 20 20 icon 20/20 Collectible Cursed Eye icon Cursed Eye (except in Rebirth) Collectible Evil Eye icon Evil Eye (in Afterbirth † and Repentance) Collectible Eye of Belial icon Eye of Belial (in Afterbirth and Afterbirth †) Collectible Explosivo icon Explosivo (in Afterbirth † and Repentance) Collectible Flat Stone icon Flat Stone (in Afterbirth and Afterbirth †) Collectible Head of the Keeper icon Head of the Keeper (in Afterbirth and Afterbirth †) Collectible Holy Light icon Holy Light (in Afterbirth †) Collectible Jacob's Ladder icon Jacob's Ladder (except in Rebirth) Collectible Kidney Stone icon Kidney Stone (in Afterbirth †) Collectible Lachryphagy icon Lachryphagy (in Afterbirth †) Collectible Lead Pencil icon Lead Pencil (in Rebirth) Collectible Monstro's Lung icon Monstro's Lung (in Rebirth) Collectible Mysterious Liquid icon Mysterious Liquid (in Repentance) Collectible Neptunus icon Neptunus (except in Repentance) Collectible The Parasite icon The Parasite (in Afterbirth † and Repentance) Collectible Parasitoid icon Parasitoid (in Afterbirth †) Collectible Pop! icon Pop! (except in Rebirth) Collectible Pupula Duplex icon Pupula Duplex (in Rebirth) Collectible Rubber Cement icon Rubber Cement (in Afterbirth †) Collectible Sinus Infection icon Sinus Infection (in Rebirth) Collectible Tech.5 icon Tech.5, unless using Character Azazel icon Azazel, in which case it will fire normally while charging Brimstone (in Rebirth) Collectible Technology icon Technology (in Afterbirth † and Repentance) Collectible Technology Zero icon Technology Zero (in Afterbirth † and Repentance) Collectible Trisagion icon Trisagion Only stat effects are applied; otherwise overridden by Brimstone: (in Afterbirth † and Repentance) Collectible Compound Fracture icon Compound Fracture (in Afterbirth and Afterbirth †) Collectible Continuum icon Continuum (except in Repentance) Collectible Cricket's Body icon Cricket's Body (in Afterbirth and Afterbirth †) Collectible Marked icon Marked (in Rebirth) Collectible My Reflection icon My Reflection (in Afterbirth †) Collectible Sulfuric Acid icon Sulfuric Acid (in Rebirth) Collectible Technology 2 icon Technology 2 Other interactions: (except in Rebirth) Collectible 8 Inch Nails icon 8 Inch Nails: Beams gain knockback, pushing enemies away in the direction they travel but not out of their path. This increases its consistency. (in Repentance) Collectible Abyss icon Abyss: When Isaac uses Abyss to absorb Brimstone, it turns into a larger gray locust, but otherwise acts like normal locusts created by Abyss. (in Repentance) Collectible Bird's Eye icon Bird's Eye: Will occasionally spawn a fire when firing. (except in Repentance) Collectible Chocolate Milk icon Chocolate Milk: Reduces Isaac's tear delay by 20%. Does not increase damage. (in Rebirth and Repentance) Collectible Dr. Fetus icon Dr. Fetus: Overrides Brimstone. (in Afterbirth and Afterbirth †) Isaac continuously fires bombs while charging the beam. (in Rebirth) Collectible Epic Fetus icon Epic Fetus: Overrides Brimstone. (except in Rebirth) Collectible Epiphora icon Epiphora: Effect only activates when holding charge in a specific direction, and deactivates when the charge is released, effectively making Epiphora useless unless Isaac has exceedingly high tear delay. Collectible Fire Mind icon Fire Mind: The beam will not cause explosions, but will still set enemies on fire. (in Afterbirth † and Repentance) Character The Forgotten icon The Forgotten: The charged attack will spawn a Brimstone ball that will float in front of The Forgotten for a few seconds before disappearing. The Forgotten will still melee attack while performing this action. (in Afterbirth †) Collectible Ghost Pepper icon Ghost Pepper: The flames can still shoot from Isaac while holding the fire button. (in Repentance) Has a chance to shoot flames for every other tick while the beam is being fired. Collectible Godhead icon Godhead: Homing and stat bonuses apply, but the beam does not have a damaging aura. (in Rebirth and Afterbirth) Collectible Ipecac icon Ipecac: Does not apply Ipecac's stat changes. The beam poisons enemies. (in Afterbirth †)Isaac shoots Ipecac tears while charging Brimstone. Stat changes from both items are applied as normal, meaning that Ipecac fires slower and Brimstone charges slower, but Brimstone deals drastically increased damage. (in Repentance)Applies +2 flat damage, instead of Ipecac's damage up. Does not apply Ipecac's tears down. The beam explodes on the first enemy or obstacle it hits every other tick, dealing 10 + twice of Isaac's Damage. The beam gains a poison effect. The explosions do not occur when the beam narrows, meaning that they occur only twice per shot without Collectible Soy Milk icon Soy Milk / Collectible Almond Milk icon Almond Milk. The beam and its explosions poison enemies. Collectible The Ladder icon The Ladder, when placed, will trigger the Ipecac-Brimstone explosions. (possibly a bug) Ipecac + Collectible Haemolacria icon Haemolacria: The flat damage bonus is +40 instead of +2. Tears will explode into multiple brimstone beams, each of which explodes and has a chance to hit Isaac. (in Rebirth and Afterbirth) Collectible Isaac's Tears icon Isaac's Tears: Fires normal tears, but nearly instantly charges when charging Brimstone. (in Afterbirth †)Fires normal tears. Charges at the same rate as Isaac's fire rate while charging Brimstone. (in Repentance)Fires normal tears. Charges when firing Brimstone. (in Repentance) Collectible Knockout Drops icon Knockout Drops: Gives the lasers high knockback. (in Repentance) Collectible Lachryphagy icon Lachryphagy: Brimstone's range is lowered, but Lachryphagy tears will form at the end of the beam, which can be fed. (in Afterbirth † and Repentance) Collectible Large Zit icon Large Zit: Creep shots will still be fired occasionally while holding the fire button. (in Repentance) Collectible Lodestone icon Lodestone: Changes the beam to gray, can still apply the magnetized effect. The beams are not attracted to enemies with the magnetized effect. Collectible Number One icon Number One: Although Number One is otherwise purely beneficial with standard Brimstone, Character Azazel icon Azazel's range is severely affected. (in Repentance) Collectible Playdough Cookie icon Playdough Cookie: Brimstone will start cycling through colors and applies the standard chance of tear-effect on hit, with the homing effect occurring intermittently. (in Repentance) Collectible Pop! icon Pop!: Brimstone has shorter range, a bit longer than the default range of Character Azazel icon Azazel's mini-Brimstone, and it is not affected by Range. The beam fires Pop! tears at the end, which are Piercing. (in Rebirth) Collectible Proptosis icon Proptosis: Does not apply distance penalty. (in Afterbirth and Afterbirth †)The beam deals 2× Isaac's Damage, which is already doubled from the item's effect, at point blank-range. The damage quickly drops further along the beam, at about 0.8× per tile of distance. (in Repentance)The beam deals 6× Isaac's Damage at point-blank range. Decreases 13.3% of the damage per tile of distance, to the minimum of 0.1 point of damage at 7.5 tiles of distance. (in Repentance) Collectible Spirit Sword icon Spirit Sword: Overrides Brimstone. (in Repentance) Character Tainted Samson icon Tainted Samson: Greatly decreases attack speed for Samson's rage mode melee attack and replaces the thrown jawbone with a large laser sphere (similarly to Character The Forgotten icon The Forgotten).

Trivia Bugs Bug Bug! (except in Repentance) Picking up Brimstone before picking up Collectible Scorpio icon Scorpio will not change the beam's color. Picking up Scorpio before Brimstone, however, will properly change it to green. Bug Bug! (in Repentance) When having Brimstone + Collectible My Reflection icon My Reflection and facing towards an east/west wall, standing directly in front of it will make Isaac shoot in reverse - the front-facing oval Brimstone beam will shoot from the back, and the back-facing beam will shoot from the front. Bug Bug! (in Repentance) PC Brimstone will occasionally fire the laser the opposite direction.