Drug Discovery Distilled for Industry Scientists by Industry Scientists\t Drug Hunter’s goal is to provide an inclusive platform that empowers, educates, and connects professional drug hunters, and celebrates the important work being done by the heroes in our industry.
Treat infections before the take over the human brain with damage and inflammation infection that’s toxic to any human neuron’s….. my neurologist wouldn’t so bye bye lost soul waste less useless service all to make a coin off anti epileptic drugs or many others lol thanks again for letting the issues cause me brain damage so I can have a life long chronic issue needing neurologist prescribed drugs. Nothing to say here about the non obstructive hydrocephalus deemed dementia a lot of the time LOL AGAIN WOW just ignore infection and physiology of the brain. Let it continue to have occurring damage inflammation neurodegenerative issues that could be attenuated but get ignored. Bye useless health services let me rot then. Been there done that seen neurologists up through the I iverstity network first 2014 then by 2020 my ventricles were so large I endured years of hydrocephalus I assume causing the epilepsy they said had no cause. lol again disappointing people look so highly to these places of fake therapy. I couldn’t get the autoimmune work up even though I told my neurologist steroids had me seizure free for almost 2 years again nothing their stupid anti epileptics could do….. Yes I see through them now after 4 neurologists of not ruling out my ear fullness been there for 14 years now same amount of years the seizures …. Chronic infections present with non acute signs and symptoms. I suppose lvl may have mastoiditis all ignored and not ruled out as causing me infection close or in my brain nor the autoimmune…. So just know they like to diagnose and adios quick to do such without proper work ups. No specialists would make sure I had no infection. The side my ears full hurts can’t sleep on it or it feels horrible the next day, hmmm!? Makes one like me think, RETHINK each thing I’m told. Wow even though an MRI SAID IT WAS INFECTION of MASTOID bilateral, 8 years after it became full one day only one ear. Told it’s not infection not an issue not a cause but it feels different the the other side it’s the side seizures are coming from and I see through all these types of people now after 14 years of studying them and their actions through my treatment and it’s only been a pill. Only thing required was to look for brain tumour in my MRI by them….. lol not safe. That’s not the only way physically a seizure can be produced in the human brain. Neurologists also disregard autoimmune issues and any physical issues like with the spine/nervous system…. Not safe for the patient.
Thank you for the nice presentation. Does this mean that current ABeta targeting therapeutics such as donanemab could lead to increased infections in patients under treatment?
Wow not good since infections and inflammation can cause amyloid….. leave the infection or inflammation not targeted and get a patient with memory and cognitive issues…. Time to play drug deals…..
How much AI assistance the team makes use of while writing these super exciting articles and how do you foresee AI contributing further in your journey. Thanks Gagan Kukreja
Hi Gagan, Thank you so much for this important question. We utilize ML and AI tools to helps us research and filter the vast amount of publications, patents and other sources produced every month. However, our validation and selection process is performed by experts in the field. All of our content is human-written and not generated by generative AI. Looking ahead, we envision further leveraging AI in research and in enhanced search, but it is hard to imaging AI displacing the level of scientific talent on the team!
Super inspiring. Besides compiling and sharing the literature, how important is for the Drug Hunter team to share their own independent insights, expert opinion/readout on the molecule being covered. Thanks Gagan Kukreja
Hi Gagan, Thanks for your kind words. At Drug Hunter, our mission is to share the knowledge and learnings acquired by drug discovery teams across the industry with scientists actively engaged in the drug discovery. We aim to facilitate easy access to the primary sources we use, enabling our readers to delve deeper into specific topics if the wish. In "Molecules of the Month" and "Patent Highlights" we follow a rigorous editorial selection process, as detailed by Dennis here: drughunter.com/blog/how-do-you-choose-the-molecules We believe that providing expert opinions is crucial, and we ensure our expressed opinions are well-grounded in facts and thorough analysis. Hope that helps.
Hi Dennis. I think there may be a misunderstanding. The EPSA means "exposed PSA" not experimental PSA. Please refer to the literature ACS Med. Chem. Lett. 2014, 5, 1167−1172; ACS Med. Chem. Lett. 2022, 13, 6, 964-971. As you mentioned, the intramolecular hydrogen bond of RMC-6291 may sheild the polarity of morpholine and amide, which results in a similar EPSA with compound 5
Thank you for your comment! In the original Pfizer paper(s), EPSA (an experimentally determined value from chromatography) was named EPSA in analogy to their previous experimental measure, ELogD (see AMCL 2014). While the "E" wasn't defined in the paper, many started to refer to this as experimental PSA and others exposed PSA, though people are all generally referring to this method.
A person with a strong background in Organic Synthesis will best succeed in the area of process chemistry. Significant training in a Ph.D program along with post-doctoral training focusing in total synthesis of complex natural products is a likely optimal route for one to pursue, however, that's not to say that a chemist with extensive training in organic methodologies development and applications to total synthesis of natural products could not success just as well. I came from a Medicinal Chemistry graduate program and we had many people with Pharmacy backgrounds who succeeded very well in synthetic chemistry careers. Overall, it's important to understand a breadth of organic reactions, mechanistic understanding and hands on applications from milligram to multi-gram scale. To transition to process, a deep understanding of physical organic chemistry becomes important since these considerations must be accounted for when working on kilogram scales. I worked in a pharma med chem lab for a decade and now in project management for the federal government, and hold process chemists in the highest respects for their elegance and optimization of initial synthetic routes. Good luck in you endeavors ~John
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