043 The details of Muscle Contraction 

You are a life savor, this is so helpful and more simple to understand compare to my college books.

I love how you go over everything a few times to help learn it, and that it's easy to understand. This has been great to help me learn and understand muscle contraction as in the lectures, they will only explain really once or twice and are sometimes more difficult to understand. Thanks a lot!

I can't tell you how much you are helping me w/ my physiology class. My professor does not teach it well at all and doesn't realize that he is ineffective. You make me feel like my goal is attainable. Don't ever feel like you don't make a difference.......

I really like how you break the process down into steps slowly and then run through them all again quickly.... It's just the way I need to learn. This will help me a lot for my A&P I class. Thank you! I'll keep my eyes out for more videos...

THANK YOU!!! Instead of reading a boring 10 pages chapter (which takes me 2-3 hours to comprehend), I watch your 10 min video and understand everything! Very helpful especially if English is a second lang! ( I am Russian)

our country needs to invest in these kinds of videos that help students learn and understand concepts if I had money i'd donate. Brilliant.

This video is wonderful! I have been struggling with anatomy and needed muscle contraction put into lamen terms. This has helped sooo much and I cannot thank you enough!

These videos are life-saving. I'm a pharmacy intern but my mind is all blank when it comes to physiology, biology and anatomy. So, THANK YOU SO MUCH!

Step 1 can be expanded on a bit: - AP traveling down T-tubule activates (Dihydropyridine) L-type Ca channels causing Ca influx - Ca influx acts at Ryanodine Ca dependent Ca channels on the Sarcoplasmic reticulum causing the release of sarcoplasmic reticulum Ca stores. - Ca then can bind to troponin C, etc, etc ,etc Other than great video!

I think videos like this are the future of teaching, it's just so much more effective than a textbook or teaching on a chalk board. You're also a very talented teacher, thank you for making this.

@369thegoose1 Awww, thanks for the feedback, and for the love :) Stay tuned for many more!

Excellent explanation!! I'm British and your accent makes everything so much more interesting!!!

Did not understand the 3 times my professor explained (actually, I never really understand unless I reteach it to myself), but your teaching is SO clear and simple to understand something that seemed so confusing and daunting. Thank you, sir!!

your accent makes learning so much more bearable, great stuff! and very selfless to put it up on-line free of charge! thanks a bundle

In 9 minutes you just did what my teacher was trying to do for over 3 months ! You explained the whole thing, and.. wouah !! I finally got it !! Thank youuuuuu

You are a great man thank you! I came in 15 minutes late to my class, my teacher explained this but I was late. Failed a quiz because I studied the anatomy of skeletal muscle but not the action of contraction.... Now I know what should have been on that paper. It was one question too.... "Describe in detail how muscle contraction occurs".. Boy when I saw that question I knew I was doomed. Thanks to this explanation I am enlightened. Excelsior !

My physiology professor literally tricks us on all the exams, and it's even more hard to do well since this info can be tricky. But because of you, I get it now!! I am a new suscriber and I'll look at your website, too! Thank you!!!! :)

Read 25 pages of my A&P book had no idea what they were flapping on about... thank you so much for making this so simple!! great teaching!!

You just saved my life. I was the only one in Anatomy who was totally confused. You are amazing. Thank you!!

@legwax100 That's awesome. Glad you are learning from the vids. Stay tuned for many more.

i have physiology right now and you sir saved me a whole bunch. REALLY love your videos. very simple to understand and enjoyable!!!! wish u were the professor...

We need teachers like you Professor! THANK YOU and God bless!!!

I have read this section again, and again in my text. Until I saw your video, it didn't make a much sense. Now it's much more understandable. Thanks!

thank you for explaining this so clearly! I wrote down each step as you described it; this will help me be prepared for my test!

Sir, you are truly amazing. Your videos have been incredibly helpful for me seeing the processes and applying the concepts and this video is no exception. Keep up the great work!

VERY helpful!!! I never would have got this concept without this video!!!

@pirateXhunterXzoro In order for the myosin head to bind to the actin, it needs to be in its high energy state. It gets that energy by breaking down ATP into ADP and an inorganic phosphate. You are correct about what happens in step 5, but that also carries over to step 2. When more calcium is released, the process happens again. Hope that helps.

@InteractiveBiology This, quite literally, saved me on the midterm on 4 different questions. Thanks yet again!

@baby3194 YOu're welcome! Keep on watching to learn more :) Have fun with all our Biology videos!

@REA0321 Thank you very much! Stay tuned for more!

Thank you so much! Your tutorials are great and you come across as being so friendly and inclusive. Your videos are so accessible, I use them to supplement my learning all the time. If only all my lecturers had your talent! :) Thank you, you are wonderful!

@izzy2imagine You are very much welcome!

@jaemo11 You are very much welcome. Glad it helps :D

If you're asking immediately where it comes from at that instant, it is brought from mitochondria which are plentiful in muscle cells. More specifically, within the mitochondria, the Citric Acid Cycle is used to convert the energy in glucose into smaller, more usable units of energy stored in ATP. The Citric Acid Cycle produces NADH and FADH2 which carry electrons to the Electron Transport Chain, which in turn produce ATP using ATPase in the mitochondrion. Search Google for more details.

Thank you so much for your time and energy. You have no idea how much this has helped me!

I don't know self how to thank you, coz these sequence of events of contractile process in skeletal muscle #excitation-contraction coupling of your's helped me alot. Thanks very much!

As a second year university student this video has really helped me, thanks a lot !

Wow, you are a great teacher. Your voice, your animation, your simplicity, and the steps you go over and over makes it soooo simple to learn!!!! Awesome! :)))))

Thanks for making "Muscle Contraction topic" interesting and more importantly understandable

a thank you from Denmark, where I'm writing my master thesis about Bioimpedance, and just needed to catch up on muscles physiology :)

This video allowed me to go from dreading learning this to actually understanding and finding it interesting. Thanks!

This is so much easier to understand than a book. Thanks

Thanks so much for making my life easier, couldnt get the muscle contraction part in my textbook and with this video, I got it. Awesome job!!!!!

Thank you! Best explanation I've seen. 👍

@anfro18 THANK YOU! We appreciate you spreading the news to everyone :) Good luck with your midterms!

am here because of my STRUCTURE AND FUNCTION CLASS in COSTAATT....excellent video!

Thank you so much for the great simplified video. :))

thank you so much your videos saved my life for this test!!

wow. he makes it so clear.from now on im going to watch all of his video

Your videos are very helpful. Thank you for contributing such great videos. I am med student and there are some great points that I am picking up from your videos. Thank you.

when i first heard you say make biology fun i thought that this would be crap but you really did make it fun and understandable

@369thegoose1 All questions are answered in the Interactive Biology community forums from now on. Go to the website in the description and then visit the community. This is to make it as efficient as possible as we have multiple people over there to help answer questions. All the best

i cant thank you enough, you are such a great man

@anfro18 Wow! That's fantastic! :) Stay tuned for more because we have a lot more coming :)

@ey7681 That's awesome. Glad to know you are getting value in the videos :D

I love this guy's accent! I feel like I'm learning a lot from him already!

The greatest video ever when it comes to mind numbing muscle contraction. It just proves the power of good teaching. There are no dumb students, there are teachers who unable to explain. Cheerrrrs! I am so happy now :)

@mo0odina Thank you! :) Stay tuned for more Biology videos coming very soon!

Very glad I found your channel, I feel like I have a chance on my next exam now :D

@GonGaRoo Glad to know. Stay tuned for more :D

Thank you,sir

Great work...very well explained in such short time...blessings

i seriously love you... thank you so much for this amazing video.... our teacher didn't even teach us this and our exam is gonna cover this as well. so i thought i was pretty much screwed. but you literally saved my life....!!! again, thank you so much for uploading such an awesome video :)

Tx for the vid, haha the accent helps a lot its so much better to listen to than some other boring vids with monotone voices.

This is such a helpful video! Very clear, concise explanation which brought these concepts to life for me. Thank you! Looking forward to watching more of your Biology videos. Feeling much more confident for my anatomy midterm coming up. :)

The sliding of the actin over the myosin is incremental; in order for the two actin molecules to become so close, the actin-myosin reaction has to happen multiple times. The muscle can pull the actin as close to each other as it wants, as long as there is calcium and ATP to power each slide. TL;DR it can be a graded response

Thank you so much!!!!!! You helped me with my Anatomy class :DD

THANK YOU! Because of you, I’ll be able to pass my quiz tomorrow. Great explanation. I more understand it. God bless you! :)

@ruddergrl1 Glad to be able to help. All the best in your class.

Informative supplement for the A&P review course I'm currently taking. Thank You!

Thank you so much for making and sharing this video! It helps me a lot. You've a lovely voice!

thanku very much i:am a 10 class grader and really appeariciate,,, ur video it actually helped me a lott and to understand every single step in binding

I was hoping to hear more about the muscle contraction beginning from the axon terminal. With acetylcolene and sodium being released

Thank you very much for making this video......it truly helps me....

Thank you, I've learned so much by watching your videos!

Excellent!!! Thank you so much for the explanation!

YOU are a LIFESAVER. Thank you so much!!! My professor isn't the most helpful!

don't know how people can't like this!

Excellent video!

Titin is a giant protein that functions as a molecular spring which is responsible for the passive elasticity of muscle.

Seriously awesome video. Just great!

Tnku very much u r a very good lecturer.I understood wt u thought 😍😍

keep uploading ---for pathology ,pharmacology and microbiology !!!! will be of great help :D

VERY NICE SIR,THANK FOR U R WONDERFUL PRESENTATION

Greetings, My name is Fransuas and I am a medical student about to take USMLE step 1. First I would like to congratulate you on your great videos. You teach in an excellent way I wish my professors in collage would have teach like that and now I wouldn't have doubts on the more complicated mechanisms. I use your videos when I have doubt or to refresh my memory. I wanted to ask you if you have a smooth muscle contraction video?(con. on next post)

What about the acetocholinase? that assists in the process of removing calcium and resituating the muscle fibrile in its relaxed state by eating up the inorganics leftover? I'm sure you know what I'm talking about. Or, by all means correct me if I am wrong. Great info though. You really can explain it in a way that fits A to B to C....etc. Thanks.

Thank you for this!

very good exlanation. Thanks a lot!

That was good but what is the function of magnesium ion on the myosin head

very well explained.I can’t thank you enough🌺🌺🌺

is this for skeletal muscle or smooth muscle ?

I go to UCLA. RU-vid has taught me most of what I need to know

You're awesome!! Thank you for making these helpful videos!

Fantastic lesson! finally I understand how all works....THANK YOU!! :)

Hi! I just want to know what makes calcium ions bind to the troponin?

great video. thanks. tell me during a muscle ATP converts to ADP only once or many times? I actually need to watch your vid about ATP and ADP. need to know what happens there and how they brake done and build up. Is awesome and your voice and your english is excellent and clear.

Very simple to understand thankyou!

thank you very much! do you have lectures for a cardiac and smooth muscles?

you're amazing! thank you!

This has cleared it up! Thank you SO very much!