13.6 Ring Opening of Epoxides | Organic Chemistry

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Chad provides a comprehensive lesson on the Ring Opening of Epoxides. This can be done under two conditions with varying regiospecificity, and ring opening in the presence of a strong nucleophile is covered first (sometimes called base catalyzed ring opening of epoxides), while acid catalyzed ring opening of epoxides is covered second. Chad concludes the lesson by providing an example of Grignard addition to an epoxide.
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00:00 Lesson Introduction
00:26 Ring Opening of Epoxides with Strong Nucleophiles
3:17 Acid-Catalyzed Ring Opening of Epoxides
8:39 Grignard Addition to Epoxides

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4 авг 2024

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Комментарии : 55

@Syllonay 3 года назад

That might have been the best chemistry lecture I ever had. You are genuine, funny, interesting and straight to the point. Thank you for your excellent teaching sir, it helped me tremendously

@ChadsPrep 3 года назад

You are very welcome, MangeUlver - thank you for saying so!

@rajikarobinson122 2 года назад

Thank you so much! This was the best lecture on ring opening of epoxides that I've ever seen.

@ChadsPrep 2 года назад

You're welcome, Rajika Robinso - glad it helped!

@DallinPlatt Месяц назад

Idk what it is about these videos but they make so much sense

@ChadsPrep Месяц назад

Glad they do!

@amalgregory4375 2 года назад

Thank you so much! I've been scratching my head for an hour with two different textbooks but this sorted it all out clearly. Ur amazing!

@ChadsPrep 2 года назад

Glad you found the channel and the video so helpful, Amal Gregory - Happy Studying!

@Czar_Char Год назад

i keep saying this man needs an award.........and i'mma keep saying it!!!! Big up from Ghana

@ChadsPrep Год назад

Thank you, from U.S.A. - Happy Studying!

@Vinayak_Nair 2 года назад

You explained this concept so well! Thank you.

@ChadsPrep 2 года назад

You're welcome!

@emiliolarrazabal5360 2 года назад

This is the best breakdown of epoxide reactions online

@ChadsPrep 2 года назад

Glad to hear it, Emilio!

@ccoppola11 3 года назад

this was so helpful! great video

@ChadsPrep 3 года назад

Glad you think so, Cararose - thanks for commenting!

@kanchanmotwani4305 3 года назад

Thank you-this helped me so much!

@ChadsPrep 3 года назад

You're welcome, Kanchan. Thank you for the feedback.

@borzoo Год назад

thank you very much for great lecture

@ChadsPrep Год назад

You're welcome.

@ADPL-tn5ix 2 месяца назад

Amazing lecture sir, thank you

@ChadsPrep 2 месяца назад

You're welcome and Thank You.

@target__iit 10 месяцев назад

Absolutely worth it 👍

@ChadsPrep 10 месяцев назад

Thank you

@stephennguni1145 3 года назад

Great video keep up

@ChadsPrep 3 года назад

Thanks, Stephen!

@laavanyarajan4444 Год назад

The best, thank you sir...

@ChadsPrep Год назад

You're welcome!

@WomannequinReviews Год назад

What would happen with the methyl group during the ring opening if it was neither dashed nor wedged from the start? Would it remain unchanged at the end of the reaction or would it become dashed or wedged?

@isaacotto3202 Год назад

Thanks alot sir!

@ChadsPrep Год назад

Very welcome.

@gracerl Год назад

This is the video that made me subscribe

@ChadsPrep Год назад

Welcome to the channel :)

@thedarkknight1865 2 года назад

Thanks 😃💖 you're best 😎👍

@ChadsPrep 2 года назад

Thanks and you're welcome!

@rf9674 2 года назад

YOU ARE AMAZING WOW

@ChadsPrep 2 года назад

THANKS!

@zcarinareimuyargas5793 Год назад

hi! what happen to the H2SO4 number 2 example?

@matthewclaveria8348 7 месяцев назад

It was just used to protonate the alcohol (CH3-OH)

@rickyl7442 4 месяца назад

I have a question, so idk if this is just a professor preference thing but for acid catalyzed ring opening my professor has the CH3OH on the top and then HCl (cat) on the bottom. So I was wondering of the placement of this means anything at all or if it doesn’t matter. Because your way makes a lot more sense.

@ChadsPrep 4 месяца назад

Do you mean above/below the arrow? There is no set rule, but the reagent tends to be written above the arrow and anything else, solvent etc below.

@target__iit 10 месяцев назад

This guy never fails to reply to comments 🙃

@ChadsPrep 10 месяцев назад

Trying....not....to....comment....CAN'T!! 😀 😀 😀

@verisa19 10 месяцев назад

I’ve a doubt, what happend with H2SO4?

@matthewclaveria8348 7 месяцев назад

H2SO4 was just used to protonate the alcohol (CH3-OH), I assume it can also activate the epoxide without having to protonate the alcohol first but both scenario works.

@eseegs 7 месяцев назад

Why would the positively charged pronated epoxide not first lose the bond to the carbon to become neutral and causing a full carbocation on the tertiary carbon. Then the weak nucleophiel could attack either side like a typical SN1 reaction. Why does this not happen?

@ChadsPrep 7 месяцев назад

Hey there, I mention a few times in the video that it can occur in an SN1 type reaction, where the O-C bond on the more substituted side will be longer and weaker than the other side (as if the ring were starting to open in that way before the nucleophile attacks) leaving a more positive tertiary carbon.

@target__iit 4 месяца назад

Hey i'm back 🧤

@ChadsPrep 4 месяца назад

Welcome back and Happy Studying!