Yes, otherwise infant mortality would be crazy high, like 250 years ago, when 1 out of 3 children died of smallpox, many mothers and infants died in childbirth mostly because doctors did not wash their hands after doing autopsies on people that died of sepsis...like the previous mother they infected. Then there was typhoid, diphtheria, tuberculosis, diarrheal diseases, hookworm, cholera, whooping cough, scarlet fever, meningitis...
Hi Mike, In addition to lymphocytes, your neutrophils and monocytes are also below the optimal levels. I think your total WBC has been hovering around the low end of reference range for a few tests now. I wonder if it’s due to calorie restriction. By the way, low WBC artificially lowers the PhenoAge in the calculator as it assumes a linear relationship, i.e. the lower the better, which we know is not the case. The curve is U shaped. If your lymphocytes, neutrophils and monocytes are all in the optimal ranges, the total WBC would be higher and ironically the calculated age would be higher. So this is a shortcoming of the calculator.
Hi @justsaying7065, I'm ok with neutrophils and monocytes being on the low side (but not too low!), as they increase during aging. But, I definitely want to increase lymphocytes...
Thanks Max. Before making that video, in the Correlations Tier on Patreon cacao bean intake is close to strongly correlated with lower MCV, so adding them back in for the next test (I had some today) is part of the plan...
Nice video as always. Do you have thyroid symptoms with a Free T3 of 2.4? I was at 2.7 and couldn’t function cognitively and wanted to sleep all day. Now I’m totally fine taking NP Thyroid.
Thanks @lv1985aa. Interesting about your symptoms at 2.7. I'm not sure if it's related to my 2.4, but sure, I could always get more sleep, although sleep duration averages 7-8h/night. Cognitively I'm ok, but I suppose that could be better, too, but it's subjective, so I'm not sure.
@@conqueragingordietrying123 that one stood out to me since my TSH and FT4 were also totally fine. It’s clear that the issue is that we aren’t converting T4 into T3 well enough. I tried everything to get it up naturally but nothing helped at the end of the day besides desiccated thyroid hormone. I don’t think Levothyroxine would be too useful for conversion problem. I feel like a whole new person now. Just my n=1.
Congratulations prof.Lustgarten for the excellent results. It is well-known that reducing protein intake and/or fat intake improves eGFR. And you say in this video that you have decreased protein and fat consumption. By the way may I ask you what are the percentages of respectively protein and total fats in your total daily calorie intake, compared to the previous Lab tests? The fact that those 2 percentages allowed you to reach an optimal level of creatinine means that they are very probably optimal for your overall health. just an hypothesis.
Thanks Abdelilah. Total protein and fat intakes are not significantly correlated with creatinine in my data, which argues against their potential involvement with improved kidney function markers. Diet composition data is coming within the next week (currently on Patreon), but macros for this test were 21% protein, 36% net carbs, 43% total fat
Waking up to this video makes for a great start to the day. These videos are tremendously valuable. Does CR increase MCV? I thought I had read this before...
Thanks @adamd9418. It could, but there are other aspects of diet that could reduce it, even on CR. For example, cacao beans are inversely correlated in my data, but whether that's causative, we'll see...
Thank you for your great work! I am very interested in your changes in food intake, espacially for Ergothionin and Niacin/ NAD etc... 👍🏻 What do you think about S-Adenosylmethionin, N-Acetylcystein or Glutathion-glycoside for more intracellular Glutathion?
Thanks @dirkheyer6871. The diet composition video is coming soon (it will be on Patreon 1st, though)... In terms of increasing intracellular glutathione, the best option would likely be supplementing with GlyNAC, as glycine and cysteine decline during aging, and replenishing them might help resist that. However, the key is measuring blood GSH and GSSG levels, to see if it works-only total GSH is available in the US, for now.
@@conqueragingordietrying123 I was reading at IMD Labor, that the measurenent of Glutathion in blood serum has a big Error and I think an optimization of Glutathion is very diffucult. Do you have a better way for measuring intracellular Glutathion? You prefer GlyNAC, but what is with S-Adenosylmethionin, is there a Study available?
Just curious. Seeing as that your total WBC is low end (which i view as a marker of optimal health, as long as crp or other inflammatory markers are low, like yours) I don't know that you would want to, or even could, get your Lymphocytes much higher, without increasing WBC, especially since your Lymph percentage is already high at 40.7, which is youthful. Curious if your average WBC was a little higher in the prior 47 test average which may explain some of the decline in total Lymphocytes. My guess is that the optimal 2000 Lymphocyte number from studies would be correlated with a much higher WBC.
Hi @frankfeather8548, lymphocytes decline during aging, so I definitely want them to be closer to 1900, not 1500. If I don't try to increase them, they may be 800 before I know it...
@@conqueragingordietrying123 Right but it seems like the only way you can increase them is to increase total WBC. The other way would be to further increase your Lymph percentage, but that already seems optimal at over 40%.
@@frankfeather8548 The lymphocyte % being relatively high is important, but so is the absolute % of lymphocytes, so I'm ok with WBCs being ~4000, rather than 3500. If the increase comes exclusively from lymphocytes, and other biomarkers don't correspondingly go in the wrong direction, that's ideal
Hi Mike, Are you aware of the updated weights for the PhenoAge calculator in a recent paper? The weights are in Supplementary Table 4. ExplaiNAble BioLogical Age (ENABL Age): an artificial intelligence framework for interpretable biological age Wei Qiu, MSc, Hugh Chen, PhD, Prof Matt Kaeberlein, PhD, Prof Su-In Lee, PhD The Lancet Healthy Longevity Published: November 06, 2023
Nice, thanks @justsaying7065, I hadn't seen this I entered the new weights, and got -3.86y for PhenoAge for my most recent test-did you enter the new weights on your end? I may have entered something incorrectly, I'm not sure
@@conqueragingordietrying123 I tried NHANES and got a negative age! I don't know what's going on there. I got a more reasonable age with UKB, but a smaller age difference than the original version.
looks great, looking great, what do you want more 😁 thanks a lot for the phenoage excel sheet, helps in determining the critical points, which is albumin in my case, hence you are shaving off 3y more than me ;)
@@conqueragingordietrying123 it's not, of course, was not meant like that, sorry for rising a misunderstanding. Just... I find it intriguing that even those who do a lot for optimization in more or less traditional ways, all land around 18 years younger bio age..If I will succeed in correcting the liver issues I will fall to the same range. Two possibilities: a systematic misconception, or a real thing... Both are exciting
Ha, no worries@@monnoo8221. With everything as youthful as possible, the maximum PhenoAge reduction is ~20y. Which other people are around 18y younger?
@@conqueragingordietrying123 I was near 18y younger when I tested this 2021 (my chronological age was not yet 51 years and using the 9 blood tests and Levine's calculator in october 2021, my phenotypic age was calculated to 33.7 years, I e-mailed you the results then and you kindly commented, very much appreciated). Still, I did not feel healthy, so it could be the results were "falsely high" due to some underlying health issue. My main goal is to improve quality of life (QoL). To live long is not that great if you often feel like crap.
Thanks @mannmstorm. Nope on the cold/infection 9hopefully I don't jinx it!), and during that time, my daughter was COVID + for 8 straight days, and had another serious (lots of coughing), non-COVID respiratory infecton, yet somehow I avoided them both Seasonal allergies in June + July in combination with my AC not being able to cool the room temp and/or humidity to ~70F, 40% seem to have a big impact on how I feel, which I can't fix until I move out of Boston. I do try to work around that in terms of blood testing, with late May and late July tests in 2024, for example.
Thanks! My understanding is that you recommend to test when you feel well/normal and delay testing if you feel a little off like a slightly sore throat (as it will influence results like increasing CRP).
@@mannmstorm Definitely, but if one has health issues at a consistent time each year, there is value in measuring during that period to see what can be done to ameliorate symptoms. but, in my case, June-July data is aberrant relative to the other 10 months, and can act as a confounder in terms of correlations. For example, it's only through rigorous tracking that I'm learning about the optimal room temp and/or humidity that may limit a seasonal impact on HRV and RHR (also worse during those months).
Mike I take note that you don't have GGT or ALP liver enzyme lab results . Any reason for their exclusion especially given that low levels of GGT were present within centenarian studies,
Hi@jimdres7000, ALP is in the video, I measure it at every test. I haven't measured GGT yet, and it will be on the September round of tests. Do you have links for centenarian GGT studies?
@@conqueragingordietrying123 I am, like most people, obstructed by paywalls. I was hoping, with your access, you could share more, assuming there is something to find.
Good results. You dont look 51 either. 40 at best. The only way to get T3 up is to stop chronic calorie deficit. As i commentrd on some previous vidoes, theres no other natural way. Btw, weight maintenance does not mean you have reached caloric maintenance. Some metabolic processes like free testosterone and T3 etc are used to buffer minor deficits so that weight can be maintained. Calories can be increased further without weight gain and T3 will improve. Wbc is low because of good health, low inflammation. But also because of your fish consumption. Omega3 is known to be immunosuppressive.
Thanks @ladagspa2008. Calories/day were 100 higher but yet free T3 and T4 didn't move, so I'm not convinced about calories in my case. That said, I'm ging to look into every other way besides higher calories to improve FT3/FT4.
