2024: Emerging Therapies and Parkinson’s 

Julia, gracias por tu mensaje. Por el momento, sólo te podemos sugerir la traducción automática que RU-vid ofrece al español. Para eso tienes que ir al ícono de "setting" en este video, dar clic, darle clic donde dice "Subtitles/CC" y activar la opción "English [autogenerated]". Después de eso, debajo de esa opción se debe haber activado la opción "Auto-Translate", haga clic allí y busque el idioma "Spanish" para que los subtítulos aparezcan en español. Si tienes otras preguntas, nos puedes escribir en español a micomunidad@dpf.org y te invitamos a que sigas nuestro canal de RU-vid de la Davis Phinney Foundation www.youtube.com/@DavisPhinneyFdnEnEspanol

The Neupro patch delivers the dopamine agonist rotigotine through the skin, directly into the bloodstream, 24 hours a day. You can read our article about the neupro patch here: davisphinneyfoundation.org/rotigotine/ In this emerging therapies webinar, Dr. Okun and Dr. Mathur discuss subcutaneous infusion systems that will deliver levodopa.

... i was just about to ask if she was sick... the amount of movements with the entire body (and espesially when speaking) made me "nouseous".

Dr. Mathur takes an active approach to managing her Parkinson's symptoms, including medications and daily exercise. Specific questions about individual treatments are best asked of your care team--especially related to DBS as there is an involved process to determine if one is a good candidate for that treatment. Tremor can be treatment resistant, and it is sometimes not well-managed by levodopa. Also, note that for each person, symptoms that are not levodopa responsive are also typically not responsive to DBS therapy. Here is a research article describing some treatments for Parkinson's-related tremor: www.ncbi.nlm.nih.gov/pmc/articles/PMC10041452/

I understand that Michael J Fox had brain surgery to cause micro-strokes. Where are we with that type of therapy

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Dr. Sinclair's work is interesting, and there are some studies investigating some of the compounds he discusses as possible interventions in Parkinson's. At present, though, more research is needed. Some more information is available here: scienceofparkinsons.com/2022/03/11/nad-2/

Sinclair is a fraud.

Thanks for your comment! We recently had a webinar on about nutrition and Parkinson's. You can view that here: ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-Z80GEQwmbZI.html It's certainly true that nutrition and diet warrant more investigation, and many people with Parkinson's notice that their diet influences their experience of living with Parkinson's. At least at present, however, pharmaceutical interventions are important parts of living well with Parkinson's for most people.

@@davisphinneyfdn 12:49 12:49 😊

Dr. Mathur does experience dyskinesia, and you're right to observe that this dyskinesia is apparent in the video.

Thanks for your comment. Cell replacement therapies are undoubtedly important and exciting! In this video, while Dr. Okun says explicitly that he doesn't want dampen excitement about cell replacement therapies, he also observes that there are many questions remaining about efficacy of these treatments. We'll learn more as trials for these treatments move forward. On that front, there was news two days ago about advancements in a clinical trial in the US: www.prnewswire.com/news-releases/aspen-neuroscience-announces-first-patient-dosed-in-first-in-human-phase-12a-clinical-trial-of-autologous-neuronal-cell-replacement-therapy-for-parkinsons-disease-302119216.html Also, note that there are complications with fetal stem cells--both practical and regulatory--and that other ways of deriving cells for cell replacement therapies prove more practical. In addition to our blog post, which is featured as a link in the description above, you can find more information about cell replacement therapies in this article written by multiple global leaders in cell replacement therapies for Parkinson's: content.iospress.com/articles/journal-of-parkinsons-disease/jpd160798