Hello Quynh! You can check it out here: www.chadsprep.com/chads-elementary-biochemistry-videos/ There's a nice drop-down menu outlining the entire course. It was designed to follow a 1-semester survey course on biochemistry. Hope this helps!
Excellent video. Just a quick question. We have to add heat here in step 3 because removing OH as a leaving group is so unfavorable right? Also, would we consider the red boxed in product thermodynamic and the other 2 kinetic?
So step 3 is an intramolecular aldol condensation. We need the heat to favor the aldol condensation mechanism to form the alkene product - this is an elimination mechanism (which is favored by heat) where we lose H2O (hence the name condensation) from the OH and H (alpha carbon) which I discuss at 5:00 onwards. If we don't apply heat we would get the aldol product (with the OH group still attached).
@@ChadsPrep It's less so from this video but more so hypothetical. Because at 8:12 I noticed that a conjugated ketone could have been formed so I was just wondering. Thank you!
We have to consider both steric hindrance and the presence of donating groups (alkyl groups) in this case which reduce the electrophillic nature of the beta carbon
