4.1 Center-Surround Receptive Field 

Yeah, I still don't get it...

Even with a great explanation like this, this shit is still complicated as hell!

Fantastic explanation about the concept of the receptive field of the RGC - I'd just want to add something in case some people had the same question as I did whilst watching this video: Both photoreceptor cells of the retina (Rods and Cones) utilise ONLY glutamate as a neurotransmitter - which evokes the question: How is it possible that an ON CENTER bipolar cell even exists, because glutamate is EXCITATORY and somehow the ON CENTER bipolar cell reverses the sign of the ON CENTER cone cell, so how such an arrangement possible? So apparently it is because in the retina we have a special type of glutamate receptor which is actually INHIBITORY, and the ON CENTER bipolar cells have these kind of inhibitory glutamate receptors on their synapses - therefore when the ON CENTER cone cell is going to release glutamate on the ON CENTER bipolar cell it is actually going to be an INHIBITORY "message", NOT an excitatory message, which totally goes against the conventional "glutamate is an excitatory neurotransmitter idea" - apparently for this type of arrangement in the retina glutamate can actually act as an inhibitory neurotransmitter because of these specialized INHIBITORY glutamate receptors.

Literally the best explanation of the On Center/ Off Surround and Off Center and OFF surround ever. It even has a animation to help you visualize the process. Please, make more... This was extremely helpful.

Really great job! It's clear, simple and well put. I was desperate, I didn't understand it, but thanks to you now I do. 👏

god this hurt my brain watching

Finally I understood most of the mechanism. The explanation is very good and the images are also very well chosen. The visual material made it so much easier to follow the auditive explanation. Thank you

Finally a clear and straight to the point video. Good work, and thank you

This was GREAT. Thank you very much. The thorough example was so useful.

thanks for posting !

Thank you for making learning fun and describing it in a comprehensive way

Best explanation of this topic in the internet

This was so helpful thank you!!

Very well explained, many thanks

Thanks for make a great animation video. Thats make this topic is more clear for me

Thank you for this. I finally understand it!

my ears & eyes:yeah now I understand my brain: no you don't

Well explained...good job.

Great video!

best explanation ever ... keep on

after 2 hours or more of reading notes and books i gave up. I watched this video and managed to understand it, thank you so much

much better than textbook or some online lectures

Best explanation!!,

excellent video!

Thank u sooooo much I finally got it 🥳

Can you please give me an live example of where it comes to use

Legendary work 🔥❤️❤️❤️❤️❤️❤️

Wonderful video

Thank you so much this saved me

Thanks! This video is much better than the interpretation presented by my teacher in university LOL

nicely explained

Thank you!

super clear explanation. Thank you !!!!!

Brillant So easy to learn

This is a way more complicated explanation than necessary if you’re trying to get a basic understanding. I wanted to link a video on the subject. I’ll keep looking.

Please can you give me a good review paper where you got this information from?

thank you!

good explaining

This was SO clear thank you so much!!!

Thank you so so so much Mam 🥺

Holy hell its amazing

One thing the video missed out is that the neurotransmitter used from the presynaptic membrane of the cones to the postsynaptic membrane of the bipolar cells is GABA. GABA is an inhibitory neurotransmitter, hence the less of it being produced the more the bipolar cell will be activated. So when a cone receives light and hyperpolarises (as mentioned in the video) it will decrease the amount of GABA released (as the cone cell cannot propagate the signal to the presynaptic membrane) and hence the bipolar cell will be less inhibited and will fire more. The opposite is true for when there is no light input, the cone cell will be depolarised so an action potential can propagate meaning more GABA will be released by the cell and so more inhibition will occur on the postsynaptic bipolar cell.

You re amazing

Sensational

I ve understood . ..but still needs clarity can anybody suggest me a book which explains this topic better.....

Maybe a stupid question but what does she mean by "preserve the sign of the cone" and "reverse the sign of the cone"?

I swear i get everything else having to do with light transmition accept for this

Even with on center off surround, why is the center hyperporalized?

This is the first RU-vid video I encountered that is harder to understand than a professor’s lecture 😢

soooo counterintuitive but great explanation

thats good

wow i get it thank mam

I'm learnding

Plz break it down further..I'm lost😲

I thought off bipolar cells keep cell depolarized

OMG now my PhD is safe!

This can't explain off center off surround.Both off center and off surround will excite the horizontal cell and the horizontal cell will inhibit the center cone a lot. And then the bipolor cell will be excited a lot.

Why tho

👌🏻👌🏻👌🏻

inte fashtoooor

on off on off on off OMG :(((

What da fuck

this shit dont make sense

I'm going to fucking shoot myself