Shiver clean with a pinch of grind boost for a little dirt, and the Brit SV20 with boost and/or overdrive is my new fave for mid to high gain (and some master volume tweak like a modded marshall) mostly with humbuckers.
Go to clean is the Dr. Z 38, mid gain I just add the Blues OD and high gain Friedman BE V3. If I played ultra high gain I’d probably use the Revv or 5150 stuff.