6.047/6.878/HST.507 Fall 2020 Prof. Manolis Kellis
Computational Biology: Genomes, Networks, Evolution, Health
Machine Learning in Genomics: Dissecting the circuitry of Human Disease
Latest slides and course today: compbio.mit.edu/6047
Fall 2020 slides and materials: stellar.mit.edu/S/course/6/fa20/6.047/materials.html
OVERVIEW
0:00 Intro and Lecture/Module Overview
4:19 Functional element discovery power
11:11 Detecting constrained nucleotides
16:50 Rates vs. Patterns of Selection
22:50 Estimating fraction constrained
29:27 Evolutionary signatures
36:05 Protein-coding evolutionary signatures
43:26 Reading-frame conservation
44:58 Codon Subsitution Frequencies (PhyloCSF)
55:55 COVID-19 SARS-CoV-2 genome reannotation
1:02:52 Revise genes, readthrough, excess constraint
1:07:30 RNA structure evolutionary signatures
1:11:05 RNA motif evolutionary signatures
1:16:43 microRNA evolutionary signatures
1:21:53 Lecture summary
1:22:34 Measuring constraint within human lineage
31 окт 2020
