A new kind of cell division 

open question: Would it be called that because the cell isn't "synthesising" anything new?

Good eye, that was easy to miss

@@roidroid my thought also. I can't find any specific definiton of the term. But the 'a' making the synthetic unusual/anti. Biological Fission defined as "reproduction by spontaneous division of the body into two or more parts... relating to, or produced by chemical or biochemical synthesisespecially." So to breakdown the term "unusual cell splitting."??

@@roidroid It is claimed in the video that the cells are not duplicating their DNA, but it may synthesize cellular organelles & other cellular constituents before dividing. Whether it happens, is not mentioned in the video.

If something analagous does turn out to take place in humans too, would we call it `asynthetic humion'?

Yes..I am a biotech major student and my snacks are now even tastier as I saw this video..I just feel estatic when these basic things take turn..it's like a new branch in time line which is yet to be explored...have a good day

absolutely. We shouldn't assume we know the basics at this point. There is so much more. Remain humble in your studies and you just may see things that have always been there.

@@devinyoung5735 working on your advice sir..every day

I completely agree and keep wondering why is there no funding in basic sciences. Being a basic scientist myself, lack of funding is a major restrain in pursuing many unanswered questions in fundamental biology. But somehow the forces-that-decide the distribution of funds, seems completely unaware of this!

If I say I'm going to look into an already studied field, nobody would give me money.

We're fishy ?

@@DAMfoxygrampa we started out as fish

@@DAMfoxygrampa in early embryonic stage, all vertebrate animals (including us) do look like fish!

@@DAMfoxygrampa we also have gills in the embryonal stages

Edit: embryonic*

2:31 "Ooh shit nevermind i forgot to pick some pieces of my dna"

Cells be like: we ran out of blocks, let's use slabs for a temporary fix.

fascinating

Wow thanks for that thought

I like your idea but, in one hand, It's said that those irregular cells are replaced eventually by normal cells. On the other hand, scars can be permanent.

Scars occur because of an excessive amount of collage build-up on the wound.

interesting idea

This video just wouldn't be the same without the sound effects.

What?

@@warbler1984 Basically, Sceintific undertsanding is based on observation and theories which often get what happens in reality wrong, we are only capable of describing/observing something to a certain point/limit, and often than not we get things wrong because of it. Its okay to realize what science gets wrong as realizing what is and isn't correct is what make science as accurate as it is. Science is an everlasting work-in-progress co-operation, if something appears that changes how it is described, it doesn't mean that science before that change was all for nothing, it just means that what we had before was inaccurate and we need to work on it so it makes more sense, to the best of our capabilities. Hindsight is much clearer than the fog of the unknown we have to sift through ahead of us.

@@themushroominside6540 i've heard it very much simplified vaguely into something like "nothing ever breaks reality, rather our understanding of reality grows with each new discovery". i don't know who said that though, i think i heard it through an educational science channel, and it might have been a quote from someone else, but i thought it was incredibly powerful and simple. basically, anything is possible as far as we know. but to the limits of our knowledge, senses, and technology that we or any other animal have at any given time determines exactly how much they're allowed to know

@@hits_different that might be where i heard it. that guy was the master of communicating to the lay man!

It's not nature being sloppy but rather it doing what it can given its current energy structure

Well, we did see an example of apoptosis there, so we know that process is used. I mean, the possibilities could be endless, but one possibility could be that they switch off their ability to divide after two divisions. I don't have a very deep knowledge of biology, but slapping some blocking protein structures onto the DNA at all the binding sites for replication and transcription would go a long way to preventing cancer in these cells. If they're meant to be temporary they shouldn't need to last very long, so they shouldn't need to transcribe too much. Maybe.

@@irregularassassin6380 That's my own view as well, non of them seem to last more than a couple of generations away from the original source cell.

The bad thing about canser tumors that it lives while it shouldn't. Canser cells achieve it by don't obeying "kill yourself" comand from white blood cells. Basically, canser cells is undying, super-healthy monsters. In contrast, cell without complite set of DNA will decay and die wery fast.

Without DNA, I suspect these cells have a limited lifespan. Think of how they would renew the RNA supply they need for normal cell function.

My thoughts turned to the origins of cancer too.

Good thought

Cant evolve backwards either... oops!

great hypothesis to ponder

no

Cell consciousness? 😁

Realistically though, there are cellular tension receptors described already. If those also exist on these skin cells, it’s very possible that it just becomes one of the signals that then get computed into the instruction divide/don’t divide along with other signals (such as growth factors etc.). Honestly, any cell is really just a biological machine where complex function emerges from a network of simple instructions, similarly to how consciousness is an emergent features of a complex network of neural signalling.

@DragonXflyer, what organelle?

@@TonyTigerTonyTiger Organelle: Any of a number of organized or specialized structures within a living cell.

@@DragonXflyer I know what an organelle is. What organelle were you talking about when you said, "all to maintain the structure of the organelle"?

I think they treated as foreign object since they propably dont produce HLA due to insufficient dna

Mad sick thought, I like where your head is at

Yes there is a mechanism to destroy cells that are ‘wrong’ called apoptosis which is programmed cell death.

In humans, certain growth factors are only produced during the fetal stage, I believe IGF-2 is one of them, but don't quote me on that. It could be that the type of cell division seen here is regulated by such growth factors, which are no longer produced later in the organism's life cycle, thus this type of division halts. And the cells that were created through this type of division probably have a much shorter life span than normal cells, and will naturally die off through apoptosis.

It looks like from the video that they die via a form of regulated cell death called apoptosis which @LukeLane1984 mentioned. You can tell because the cells 'bleb' or separate into lots of little membrane-bound capsules. These 'apoptotic bodies' are cleaned up by phagocytotic cells called macrophages. Apoptosis is extremely widespread in development and continues to happen in adult organisms. I think what probably happens is these cells undergo apoptosis as they receive signals at a certain point in development which tells them to undergo cell death, and are then replaced by normal cells. I'm not sure how they stay alive until that point though, as one signal that initiates apoptosis is DNA damage! (I'm a biochem undergrad in my 2nd year).

It's not a channel, but the CBC's radio show _Quirks and Quarks_ (available as a podcast) is (almost) exclusively short interviews of scientists who have had new discoveries. The show covers all scientific fields, from archaeology to quantum mechanics to cetacean biology. The host, Bob McDonald, is a great interviewer who gently draws the information from the scientists, and helps rephrase it in layman's terms very well. I learn so many new things while listening all the time.

Yeah, because it's how discoveries work. Lol

Only after some replication studies have also occurred. To keep p-hacker reports to a minimum (hopefully)

Cancerous cells don’t really divide any faster than regular cells. They just don’t die like regular cells do

Yes. My thought too.

@Questa Semplice Animazione and their reproduction is very limited, which makes them the opposite of cancer

One of the best videos ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-8DX398Wj6XA.html

Yeah 🌈😍 It helps that zebrafish are smol and basically see-through, and that skin cells have to tile the surface. I remember when neurobio folks were developing this sparse genetic labeling a while back, so they could individuate neurons… the technique was called “brainbow”, if you want to look up the history of how they got to this probabilistic Voronoi coloring situation (lots of pretty figures). So cool to see what kinds of questions researchers are using it to study in other organs… even where the cells are constantly replicating and changing things up on you (as opposed to neurons, which mostly don’t). That’s why they need video, wow. But it blows my mind that in the process they found something totally new. I feel like it helps that the datasets to be analyzed are so pretty. More motivation to stare at them for hours and notice things that you currently believe to be impossible.

@@sasentaiko🧠🌈🥳 Thanks for telling us about this.

It took me until the end of the video to realize he has a goldfish ornament because he works in a zebrafish lab.

Oh I missed that lol, thanks for pointing it out

this is crazy

I love this comment section. It contains many testable hypothesis. I hope the scientists of this video will read the comments and test what your saying out.

zebra fish do have a lot of amazing regeneration functions

I'd imagine the disappearance comes from eventual cell death due to not having all of the necessary genetic information. But by then the 'normal' cells have had time to replicate DNA and divide properly.

This sounds like a good project

SAMEEE LOL. but this was very fascinating tbh.

Cute pfp you got there 🥺

@@averageneetaspirant3252 thanks, you too

I would think this kind of replication would be self limiting. But it seems these pathways could have a role in cancer in ‘normal’ cell division. It will be interesting when the initiating MicroRNA is known for this kind of division.

No, because these cells are essentially ripping their DNA apart every time they separate, it is impossible for the cells to exist long term even if they have the correct nutrients. This is likely just a short term way for an animal to gain surface area as their internal volume grows during their developing stages.

No because they aren’t replicating the DNA