I actually am in love with you. Thank you so much for making these videos, you do an excellent job organizing and explaining the information, and I actually understand biochem after I listen to you!
I'm very detailed oriented and your lectures help give a solid baseline to think from...not to mention med school is busy as hell and it saves me a lot of time! Appreciate it bro #GRINDTIME
Was wondering the same thing, but remember the hydrolysed ATP during the activation step is converted into AMP instead of ADP and yields 2 pyrophosphates instead of one phosphate. That's equivalent to 2 ATPs.
sir i really love ur videos... u always give reasonable xplanatn...bt i hv a question...as acylcoA cannot enter the mitochondria it converts to acylcarnitine n again aftr tht it forms acylcoA on reaching the mitochondrial matrix so what is the purpose of the formation of first acylcoA in cytoplasm???..will u plz answer it sir plz
Really good one! I am Spanish and I understood it perfectly! But I have two questions: How does the CoA get into the matrix to reform the Acyl-CoA? And how do Carnitine and Acyl-carnitine go trough the outter membrane? Thanks!
There are separate reserves of cytoplasmic and mitochondrial CoA; the mitochondrial CoA doesn't move out, but the cytoplasmic CoA moves back in via Cartinine Acyl Translocase II back into the cytoplasm. As for the the second question, the outer mitochondrial membrane is relatively permeable due to porines, so Acyl-Cartinine can simply move in. I know this was asked a year ago, but I thought I should share in case someone else has the same question.
@@MonkeyDLuffy-xr4fl the answer for first question is that not because of acetyl CoA that were produced during pyruvate undergoing oxidative decarboxylation of glycolysis product...??
Hello sir, I have a doubt you haven't explain why acylcoA needs to be converted into acylcarnitine, i mean what is the significance of doing so. Also big fan of your videos, greetings from INDIA 🇮🇳✨
Mimi Sa'ari It moves from CoA to carnitine, and the fatty acyl carnitine is then transported into the mitochondrial matrix, where the fatty acid switches back to CoA and the free carnitine moves back into the cytoplasm. Did that help?
