I don't get why people complain about how he explains in the comment section. I listened to his video at 2.0x speed while working on something else, and it was very easy to understand and straight-forward. Very well explained.
Wow you just explained this so well thank you. I've been looking for this kind of information all over the Internet and you're the first source that I've found that isn't opinion based and biased. I never comment on videos but I'm currently on vyvanse so my brain feels like writing a paragraph over the information it just absorbed.
Thank you! It was tremendously helpful! I am not a chemist, but I have learned about different antidepressants and ADHD medication enough to understand your explanation very clearly.
Adderall vs Vyvanse @ 10:00 answer starts(listen to whole thing if you are not from medical background) , once you understand that Adderall is mixed( Levo & Dextro) amphetamine , while Dexedrine is Dextro-amphatmine Vyvanse is Lysine + Dexedrine is Just one . NOTE: You can't snort as you need stomach enzyme acidity to break Lysine -Dextraamphamine bond. I am sure people will find way to abuse anything. If you can take more than prescribed medications, and if you take them enough, you are abusing it at the cost of downregulating the dopamine receptors, and going on dangerous addiction path. Good Videos.
Hydrolyzing Vyvanse (lisdexamfetamine) was ORIGINALLY believed to take place in the stomach as an acid-catalyzed acyl substitution, so I don't blame you. However, Vyvanse is mostly absorbed intact from the small intestine. It is hydrolyzed by esterase enzymes in blood. Snorting Vyvanse probably does not work because it is positively charged and cannot cross the mucus membranes of the nose. Injecting Vyvanse has been shown to get you high, in pioneering research done by kids at your local Emergency Department.
Thank you very much for this explanation. I've been taking adderall IR for about 4 years now and was wondering what the difference was between the three. You have cleared this up. You earned my like.
It 2022, in March, and I just found this video but it is still so helpful for me. Thank you! I have had the worst time trying to get my ADD medication dialed in because I have the absolute most uneducated people in the area of ADD/ADHD medication‘s, prescribing my Vyvanse. ADHD medication do not take weeks or months to dial-in. They’re not Anna depressants or something, they don’t take forever and a day to start seeing if it works for you or not. It takes literally, 5 to 6 days to know if you are on the correct dosage and the right set up. Meaning, you shouldn’t have to keep increasing your medication because it stops working, which is my current problem. Instead, Dr. Parker says in another video, who specializes in us, you need an afternoon dose that’s a short acting to carry you through for the rest of the day. But since I have to be my own advocate and my own educator, these videos are what help me when I have to go in for another prescription (as by law, schedule 2 medications, they can only give you 3 months at a time and they’re 3 separate individual prescriptions, not refills.), and explain it to them with all the information/knowledge I have gathered on my own, in hopes that they won’t argue with me and treat me like I’m a drug seeking addict. It is awful to be treated like a pill head because everyone else ruined it for people like me, who actually do have ADD.
The best explanation I've seen online. And you confirmed my own conclusions about the increased ethicasy of dextroamphetamine compared to the racemic mixture. Who wants increased levels of norepinephrine when they're trying to focus?? I also like how you rightfully attributed this fuckup to the pharmaceutical industry and the patent process without dwelling on the politics and getting up in arms which would have been off topic. Great video, well done mate.
My doc put me on vyvanse cause adder all made me so anxious and paranoid and now I know why she did that. I always thought these drugs were all the same. I don't feel no physical side effects like I use too and no wonder I can't use vyvanse in the gym also. Aderall worked like a charm there . Thanks for this info . Helped a lot
This man is quite intelligent. Thanks for your exquisite explanation. One of the better ones I’ve ever seen on RU-vid over the course of the last 12 years. You have the potential to become a full time youtuber if you had the interest. I digress, I learned a lot from you today. Will be consider asking my doctor for a switch off Adderall to something that wears off sooner than 12+ hours
Thank you so much for this as someone with ADHD who wants to know WHAT IS HAPPENING and WHY THIS AND NOT THAT and so many other things, thank you so much. My need to know has been sated.
Appreciate the video immensely! Just switched back to adderall from vyvanse. I felt as if the half life of the drug made it harder for me to sleep than adderall, which makes sense now.
Make a video on DMAA and how it compares in effects and in molecular structure to Adderall, Vyvanse(dextroamphetamine), and Ritalin. Dmaa is or was a big thing in pre workout supplements. Im curious if its effects on cognition are similar to dextroamphetamine or adderall cuz it can still be gotten online for cheap wit no script as a "reaearch chemical" like $15 for 1 gram
this was an excellent video i can not praise it more i now have a complete understanding of vyvance and adderal! i have been looking online and starting to learn it now i get it. thank you kind sir
Thank you for the explanation. I actually learned a lot. I wanted to know if I should switch from Adderall to Vyvanse for my ADD and it looks like Adderall generic is just as fine.
Hi! I have a question, even if the video if somehow old, but I have a question I can´t find a straight answer for, and u said u had researched the topic... Do you have any idea about how can Dexadrine cause more physical side effects than Adderall for some people? It doesn´t seem to make sense. Both the little chemistry I know from college and the "research" I have been doing this past year support exactly what your video says, that it is the Levo the one that causes most of the side effects( heart punding, insomnia, etc...) but still I know Dex has worse effect on those areas than Adderall for a bunch of us...Do you have any idea of how or why that may be 0.0? I haven´t manage to get any straight answer besides "everyone reacts differently", but this sounds like a very weird kind of different, when one isomer has an effect it just shoudn´t have at all... So I´d appreciate your thoughts on it Thanks!
I don't think you can snort it. from what I know about digestion, protein breakdown takes place in the stomach and then continued in the small intestine by proteases. isn't this the case?
With Vyvanse, release begins from the small intestine, the l-lysine gets cleaved off by stomach ph, and releases the dextroamphetamine. (making it strictly biologically activated.) Levoamphetamine effects the PNS nervous system indirectly effecting nor-epirnephrine.
I've personally taken both but I was only on Vyvanse for ADHD for a couple months in the first semester of my senior year in fall 2010. The doctor took me off of it because my social worker at school and my therapist at the time thought it was causing me to act up. However, Adderall and later concerta also did the same thing, but although not quite as much. I think I was able to sleep a little more easily on Vyvanse though, and didn't perform quite as well academically on it compared to the regular Adderall concerta. However on Vyvanse I had less tics compared to when I was on the other. I also had a dual diagnosis of bipolar and also took risperdal for it from 2003 to 2012. Some years later ASD was officially diagnosed and bipolar was dropped and I no longer take ADHD meds.
Adderall/l-amphetamine really helps my mood for some reason while vyvanse/d-amp is solely a focusing tool. Adderall fully cured my bipolar problem for ~8 months'ish so far. Amazing time we live in.
Same here. I need the L amphetamine for more full coverage dopamine boost. Just pure amphetamine (Dexedrine), doesn’t have any mood elevation component, and no body stimulation. Not bad, but I def prefer a mix salt treatment
To my knowledge, levoamphetamine was never approved or marketed in the US. I could check the FDA website, but making it enantiopure costs money and I have never heard of a motive. In contrast, levomethamphetamine is called levmetamfetamine and is marketed for nasal congestion.
Hi! Not sure if you will ever see this, but I'm curious about something and would appreciate your feedback. I took vyvanse for several years and it worked very well for me but recently stopped working. I suddenly had horrible side effects ("physical" anxiety, lack of focus, restlessness, repetitive fidgets/ weird muscle movements, intrusive thoughts, etc). I am now on adderall and I feel less anxious, less restless, and more focused. Considering what you explained about the two drugs, I cant imagine why this would be the case if the l-isomer is the one that increases physiological symptoms of anxiety. Any ideas? Thanks for the honest video, your content is valuable.
Hi, I know this is an old comment but maybe I can contribute. I should preface by saying I am not a psychiatrist or a pharmacist, so take this with a grain of salt (haha pun). If the dosage of adderall and vyvanse are approximately the same then you are actually receiving more dextroamphetamine by taking vyvanse due to only 75% of adderall being that compound. However it is unlikely that your dosages over time were exactly the same, so I’d have to know what they were to comment more on that. The other thing that I personally felt was neglected in this video is that the release time of each compound matters a lot in terms of the effects. The faster the release happens the more of a “high” one gets, for example when someone snorts adderall at a college party. Vyvanse, due to its extra step, has a much slower release time and this means that the therapeutic effect tends to be more stable over time as opposed to adderall, at least in general. Finally, the way each one is metabolized is heavily impacted by an individual’s physiology. My Dr even told me that I should not drink lots of orange juice as it could affect my stomach’s pH and allow less of the dose into my system! Having a relatively “inert” version of the compound prior to it entering the blood could have a large effect depending on an individual’s digestion.
Wow, so helpful. I'd love to hear this excellent presentation style on comparing dextroamphetamine and methylphenidate. Also this is gonna save people a lot of money.
so I've been on Vyvanse since 2012 and it's now 2017 and I really want to change things up and I did the other day! got prescribed dexedrine 30mg IR. but supposedly the pharmacy I'm at won't support it or maybe there is an insurance problem.... Any tips?
Do you know if Dexamfetamine Sulphate is another term for Dextroamphetamine? If same/different do you know what the equivalent dose of Dex-Add would be? Great video, you covered everything so clearly
ok, so now that adderall IR as well as XR is available in generic forms, WHY do doctors still prescribe 'mixed amphetamine salts' aka generic adderall when dextroamphetamine (dexedrine) is really the only useful molecule? Would it be reasonable to bring this up to my doctor and request just generic dextroamphetime? Also, I recently came across another ADHD drug called Evekeo™ which is 50/50 levoamphetamine/dextroamphetamine. Seems like they're reinventing the wheel. What do you think???
Have you ever seen street Amphetamine being made? It's unhygienic,it's explosive environment,it's rotting people's stomach linings and there teeth. I paid $189 for a tub of 28 Vyvanse capsules yesterday,only 30mg capsules,but I can definitely say hand on heart Vyvanse is very euphoric feeling. Plus it's clean and won't ruin your teeth. Dexedrine (Dexamphetamine sulphate 5mg tablets Vyvanse capsules 30mgs Adderall 30mg capsules. Dexedrine is very affective in stopping people use street Amphetamine and get them of dangerous unhygienic Amphetamine,which rots the users the teeth,and lining, psychiatrists for the majority do not agree with prescribed Amphetamine to stop illicit use of Amphetamine made in a bath,with more adulterants than Amphetamine. Fact. Portugal legalised drugs and look ,drugs are taxed,and regulated,crime rate has fallen by 52% ,no drug dealers making money of people's misery. It's safe,it's taxed,less people are dying due to poor quality drugs,look at Alcohol the most problematic and addictive substance available without prescription and people die daily due to Alcohol .
Can someone please explain to me the difference with Vyvanse and Adderall and meth and speed? I always get into this argument and i am tired of getting called a meth head!
Yes hello dextroamphetaine- is it otc available? How is dex. Modified to become effective? Also could one supplement the amino L To create the same effect?
Amazing and clear review, thank you! I have a question regarding statements made 03:00-03:25. Specifically you mentioned that the levoamphetamine in Adderall, releases or somehow effects the norepinephrine which I assume is a positive and necessary process, helping the dopamine get transported or attached to the receptors...? Would the absence of levoamph... in for example Vyvanse or Dexedrine have a negative impact on the norepinephrine release and therefor affect the dopamine negativley(in terms of absorbtion/transport/attachment)? Or does dexoamph... also take care for this norepineph... release and fully or to some degree? I am above all assuming norepinephrine release is positive...(maybe that is not the case?).
+Aname No it has nothing to do with dopamine release. It was added to extend the patent, since now it is technically a new compound. If anything it is detriment to concentration as it activates the sympathetic nervous system, which prepares the body for action, which in turn makes it more difficult for one to sit still. In England, where the company that makes Adderall is from, they never approved it, because for study purposes it is less effective than dextroamphetamine for the reason stated above, therefore they did not approve it because it would be a waste of billions of dollars. It was developed for the sole purpose to replace the money they were going to lose when the patent of Dexerdine (dextroamphetamine XR) expired.
having experience with the adhd-meds, including ritalin/concerta, i prefer vyvanse. i like the slower gradual onset. adderall was good but due to the various salts and metabolism rate i found the onset a bit jerky. dexedrine was fast but it also has a lot more abuse potential (sniffing & injection) which is my understanding as to why it's not as prescribed. ritalin was too short lived whereas concerta wasn't, although with that i was clenching/grinding my teeth. btw - i'm coming at this from a therapeutic perspective, not someone whose used these recreationally. fortunately where i am in canada i don't pay a cent for any of these :D
On Concerta was it effective for you. I’m taking adderall but I feel like my metabolism runs through it quick so it doesn’t feel as effective but so did the XR version
Hey no prob. I'm actually going to make a min documentary about the history of these drugs. You'll see why one would be so cynical about the patents. Its important because how one one gets rewarded dictates what products are produced.
TLDR; Adderall takes immediate effect and requires multiple doses, Vyvanse takes approximately an hour to kick in and lasts longer; only requires one dose a day. Vyvanse (most likely) does not work properly or at least as effectively if snorted. Vyvanse is approximately $300 (as someone that has been prescribed a daily dose of Vyvanse, I can confirm this. In my experience, the price does not change based on the mg dosage.) The medications are very similar but, again in my experience and own research, have different side effects. From what I have asked two different doctors, Vyvanse is far more natural and safe than Adderall. Adderall is also far cheaper than Vyvanse (probably due to the whole patent thing) and, according to the person in this video can range from $10-$70, depending on where you're from. It is vital in my opinion to note that (at least in Canada) if you visit your psychiatrist, s/he can give you little prescription cards (no idea what they are actually called, sorry!) that you can give to the pharmascist whenever you are due for a prescription refill (they may not allow you to get a refill if it is more than something like 24-48 hours before necessary as they don't want to risk any possible prescription abuse on your part) and it is far cheaper that way. I believe it's something like $50-something for it in that way. (Only been on it a few months and my father is the one that keeps the cards on him and does refills so I don't know anything about it besides that, sorry!)
I was prescribed adderall XR. I am 51 years old.. I’m on week one. I started at on 5mg, no effect. I’m up to 20mg, I haven’t noticed anything. My focus hasn’t improved. I still have an appetite. Is this normal?
Evekeo is racemic amphetamine and it was launched in the US recently at high price. Benzedrine was the ORIGINAL commercial formulation of racemic amphetamine, I believe Benzedrine launched in the 1930s as an inhaler and as a pill in the early 1950s. Benzedrine was then replaced by the enantiopure Dexedrine, made by Smith-Klein French (SKF), which has since changed its name.
Donivan Reis Vyvanse is dextroamphetamine bonded to an amino acid. In the blood this bond is broken leaving dextroamphetamine. It would be like the difference between an orange that is peeled and one that is not. It is one way to repatent a drug, since now it is technically a new compound. It would be as if you had a patent for peeled oranges and that expired. You would then patent the unpeeled oranges, since technically it is different compound, and continue to sell it for the patented price. They are both oranges and the same thing. Dextroamphetamine is peeled, Vyvanse is not.
@@Yippeekiyaymummy Sometimes a certain drug might not be right for you which is why you should bring it up to the Doctor prescribing them so you can try other medications. But as someone else said, its not a magic pill, you also need to work for it
Great video. BTW, interesting pharmacology, but the bigger and more muscular you are (more lean mass), the longer Vyvanse will last. The reason is because more blood volume means the drug disperses into more blood, and your body only makes a certain amount of the enzymes to activate it. I found studies on PubMed about this. Vyvanse is a lot better than Adderall, at least in my case. Frankly, I think the only real downside of Vyvanse is it can last sometime too LONG! I take it with Intuniv (guanfacine) which HUGELY help extend it even more. Great combo. Good video.
I think that although you are factually correct in saying that there is technically no difference between the 2 base compounds, the inhibitor has some positive aspects that help make the drug a lot more sustainable for certain patients. Since the drug requires protein and amino acids from food for it to work, it forces you to keep up with your nutrition giving you an incentive to eat as apposed to adderall which can have a greater negative effect on your appetite. This helps to extend it's effectiveness and provide a more consistent, level feeling of focus which is preferable to the distracting peaks and crashes of other versions. It also makes it easier to come off of since it seems to stay active for a while after you stop taking it so the come down is less pronounced and it doesn't give you the same "I need to eat everything" crash that adderall does.
wow that was so helpful man. PERFECT EXPLANATION. I'm in AUS and this drug just came in the market, will be getting 70mg Vyvanse for $32 as we have PBS (Pharmaceutical Benefits scheme) along with my normal 5mg Dex amphetamine IR for ADD. thanks again mate
Wow, thanks for the clear explanation. I just got prescribed Vyvanse price is out the ass expensive however, my insurance covered cost but they didn't want to my doctor had to give them an explanation as to why I need vyvanse instead of addreal because they didnt want to pay for it. eneded up getting approved my dr had to throw the word bieng eat disorder and adhd to get it approved. lol toatally ridculous
Lauren A Ask your doctor to write you a prescription for Dexedrine extended-release spanules. My insurance stopped covering vyvanse so I switched to cheap generic Dexedrine spanules. If your new med isn’t helping you might need a higher dosage.
Been prescribed both, sometimes at the same time. 1-75mg (orange/blue) capsule of Vyvance in the morning, & 3-30mg tabs of Adderall taken throughout the day. Being said, Shire’s original product Adderall (Amphetamine Salts) is far superior to Shires new gimmick Vyvance.
Zenzedi is exactly the same as Dexedrine and somehow it looks like it got a patent. I am not a lawyer, it may be a "branded generic" similar to Methylin, which is generic (non-patented) Ritalin, trade name methylphenidate, with a special trademarked name - specifically, Methylin.
+My Balloon Guy Sorry about that, I originally made this as answer to someone who was a chemistry student. I honestly never expected that so many people would watch it. Most of my videos have less than 50 views. What I will do is make a new channel devoted strictly to medicine and healthcare and try to make it as concise and understandable as possible. I made a test video, different type of drug, but if you have a minute check out and let me know how you like the format. If you think its good I'll remake this one in that style.
@@14thSun mate,i bought a tub of 28 X 30mg Vyvanse made by Shire Pharmaceuticals. Ive never took these before,i live in the UK where we just have Dexedrine 5mg tabs,i took 5 of these last night,fuck me i was euphoric and chemically close to God. There great,but 28 cost me nearly $190
So weird. Evekeo was the first stimulant I tried that didn't make my heart rate go up and it is 50/50 levo and dextro. Adderall gave me the worst panic attack of my life.
