This week’s Fertility Fact Friday is all about the protocols for Frozen Embryo Transfer preparation.
There are 3 major methods:
-Cryo-natural cycle
-Stimulated ‘natural’ cycle
-Medicated cycle
So which ones is better? Based on the data - they are equally effective. A Cochrane review combining 31 randomized controlled trials, published in 2020, concluded that medicated vs cryonatural FET had NO difference in live birth rate or pregnancy loss rate.
There are certain pros/cons to consider for each:
-Medicated FET cycles allow for more precise timing and control of when the FET happens - this can help to guarantee your doctor can be the one to do the transfer.
-Cryonatural cycle FETs mean less medications need to be taken. This may be advantageos especially in patients who want to avoid taking estrogen due to medical conditions. The downside of cryonatural FET is lack of control over timing and the potential risk of cancellation of the cycle if you ovulate earlier than expected and can no longer pinpoint when progesterone began to affect the endometrial lining. There may be a slightly lower rate of hypertension/preeclampsia in pregnancy after cryonatural FET vs medicated - as there may be factors released from the ovulated follicle in the ovary (relaxin) that can be protective.
My preference is medicated cycle - but I will modify to cryonatural as necessary.
Questions?
#fertility #infertility #ivf #fertilityjourney #ttc #pregnancy #ivfjourney #pcos #ttccommunity #infertilityawareness #fertilityawareness #ttcjourney #womenshealth #health #endometriosis #fertilitytreatment #iui #ivfsuccess #baby #fertilitysupport #infertilitysupport #ttcsupport #infertilitysucks #pregnant #tryingtoconceive #ivfsupport #miscarriage #infertilityjourney #icsi #ivfcommunity
1 окт 2024
