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Great video, but the tricks are not accurate and can be confusing. You left out Vancomycin, which is not an aminoglycoside, but technically ends in "-mycin". Also, a lot of the Lincosamides end in "-mycin" and are clearly not aminoglycosides either. The other thing is Neomycin is technically an aminoglycoside and it is NOT parenteral. Otherwise, I love your simplification of a topic that can be very confusing.
Great video!! Simplified and clear. Kindly note that Aminoglycosides may be used for Aerobic Gram-positive bacteria such as most Staph aureus, Viridans group Streptococci and Enterococcus BUT they must be used in COMBINATION with another antibiotic.
I was injected the gentamicin directly into my vain back in 2004 and never forget about the side effect I felt right away. I never felt such a pain from an injection in my life. My arm was on fire, it felt like I was injected with peri peri or something like that. The pain was so intense that why I never forgot about the name of this injection. P.S. I was hospitalized 10 days for severe malaria and typhoid and was getting IV treatments.
Aminoglycosides, being weak bases, have optimal potency in alkaline media. The lower the pH the weaker the effect. If you want to exploit this, use a urinary alkaliner when using AMG's to treat UTI's.
Wait,, according to this video aminoglycosides kills only gram negative bacteria ,,,but is is used in tuberculosis which is caused by gram positive bacteria,,can you explain this?
Aminoglycosides causes incorporation of incorrect aminoacids in the growing peptide chain..this will alter protein synthesis and alter cell wall permeability. Causing cell.wall.lysis and hence cidal
According to some other sources aminoglycosides bind to 50s domain. Aminoglycosides bind to magnesium in rRNA on the 50s domain. What can you say about that? Have you heard about it? It’s strange that different sources give different info.
