In this video, we review amyloid beta (Aβ) generation from amyloid precursor protein (APP), Aβ endocytosis and intracellular trafficking, and mechanisms of Aβ-induced cell death and neuroinflammation.
What mechanism mediates the beta/gamma secretase cleavage? At least in this video, it seems to initiate the entire cascade, or at least is a culprit in the main machinery that's responsible.
