A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: kikoxp.com/posts/5084 (dermpath) & kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology). Also, Useful new info on angiomatoid fibrous histiocytoma: - They often express ALK-1 www.ncbi.nlm.nih.gov/pubmed/29877921 ; don't confuse AFH with inflammatory myofibroblastic tumor (see my video on IMT: ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-7Dl_bofTYYs.html ) - They may express TLE-1, giving me yet another reason to dislike TLE-1! (www.ncbi.nlm.nih.gov/pubmed/28248724 ); don't confuse AFH with synovial sarcoma (see my video on synovial sarcoma: ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-ERUTFHJ1zZM.html ) -They may express MUC4: www.ncbi.nlm.nih.gov/m/pubmed/31652145/ (don’t confuse with low grade fibromyxoid sarcoma...although they usually look quite different morphologically; check out my video on LGFMS: ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-QDb68_G1HR4.html ) - They may have pleomorphism or a range of other unusual histologic features. Great paper on this by my friend Summer Bohman and colleagues: www.ncbi.nlm.nih.gov/pubmed/24614712
Dr. Gardner, these videos are an amazing resource. I am incorporating many of your teaching points into my signouts and am feeling much more comfortable in working up challenging cases. Please keep doing what you are doing. I am eagerly awaiting your next video!
Thank you! That means so much to me, to know that these videos help my colleagues better care for their own patients. I really appreciate that feedback. Hope to have a new video sometime in December.
Great job, Jared! Thank you. The length of the video, amount of discussion and demonstration of different features and several cases is excellent! And it's nice to take a "little bite", rather than the often overwhelming litany of unusual tumors typical of a 1-hour conference talk. For these reasons, while I've not encountered this entity before, I think I stand a good chance of remembering it if/when I see it, even several years from now. I look forward to future videos!
Loved your vide.o!! Amazing work. This is so easy to follow. The quality of the video is too good. Keep up the good work Gerad. Hope to see many more videos here
Thanks Jerad. I got a case this week that I am working on that I think is an angiomatoid fibrous histiocytoma. I did not know that they could be EMA positive. Good to know because our differential diagnosis was epithelioid sarcoma.
Hi Yve. AFH can express EMA and desmin but are usually CK negative. Justin told me about your case and explained that it was very atypical. That is quite unusual for AFH but not impossible (www.ncbi.nlm.nih.gov/pubmed/18422688). Please keep me updated about the case!
Great session, Jerad. Thanks a mil! BTW, I never understood how to distinguish a "pseudocapsule" from a true capsule. Maybe you can explain that to me sometime.
Yve Huttenbach Thanks for the follow up info, Yve! I would love a recut of that case if you have one to spare. My email is at the end of the video if you want to get in touch with me directly ever.
My Gf has lung cancer it was in her blood she had neurofibromatosis as a child then the tumors got cancerous in her lungs then she did chemo and after her second round it spread to her lower back and was in her blood idk what type she had it sounds close to this but the oncologists said it was a type of sarcoma didnt know specifically what it was. Its really rare and progressive nothing like he has ever seen please give me some knowledge she is still alive but not expected to live and past the time they gave her to live she is tough .
I'm so sorry to hear this. It's difficult to know what exactly is going on from this description. Having the pathology specimens reviewed by an expert pathologist might be helpful. I wish peace and healing to you and her during this very difficult time.
Sure happy to explain the best I can. My email is JMGardnerMD@gmail.com. And just FYI the term “angio” is included in many many different unrelated diseases.
