Antianginal Drugs Pharmacology | Dr Najeeb🩺 

#antianginal #antianginaldrugs #pharmacology #drnajeeb #medicines
Antianginal Drugs Pharmacology | Dr Najeeb🩺
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▬▬▬▬▬▬▬▬▬▬ Contents of this video ▬▬▬▬▬▬▬▬▬▬
00:00:00 Introduction, what is Angina?
00:03:52 Types of Angina
00:04:52 Pathophysiology of Classical Angina
00:11:50 Pathophysiology of Prinzmetal Angina
00:15:42 Pathophysiology of unstable Angina
00:24:15 Pharmacological strategies to manage classical angina
00:25:58 Pharmacological strategies to manage Prinzmetal Angina
00:30:28 Pharmacological strategies to manage unstable Angina
00:34:50 Preload and after load, Determinants for the work of the heart
00:44:34 How antianginal drugs should work
00:54:40 Reduce the Preload of heart
00:58:30 Example
01:02:07 Reduce the After load
01:08:02 Reduce the heart rate
01:14:50 Long term management of Angina
01:17:46 Classical management of Angina
01:18:16 A) Nitrates
01:19:27 GTN
01:26:00 Isosorbide Dinitrate
01:27:10 Isosorbide Mononitrate
01:29:00 Why mechanism of nitrates loses its action after sometime?
01:38:36 Monday disease
01:42:36 Physiology of smooth muscle contraction and pharmacological action of Nitrates on them
01:56:24 Recap
02:00:34 Adverse effects of Nitrates and their reasons
02:18:08 B) Beta Blockers
02:26:24 Selective and non-selective Beta Blockers
02:29:00 Role of beta blockers in Angina
02:36:49 Combination on Nitrates and Beta blockers in Angina
02:46:35 Adverse effects of Beta Blockers and their reasons
03:28:50 C) Calcium channel blockers
03:39:23 Role of Calcium channel blockers on heart, Heart block and its types
03:58:44 How Calcium channel blockers alter the mechanical and electrical activity of heart?
04:28:58 Adverse effects of Calcium channel blockers
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Antianginal agents are drugs used to provide immediate relief from angina symptoms and prevent angina attacks.
Angina is chest pain or discomfort that happens because of reduced blood flow to the heart. Angina results from an imbalance in the oxygen supply/demand ratio. Due to the lower oxygen supply and greater oxygen demand, there is increased pressure on the heart. Constriction of blood vessels and formation of blood clots may be the major reason for disturbing the oxygen supply/demand ratio.
Antianginal drugs act by:
Increasing blood flow to the heart
Increasing oxygen supply to the heart
Dilating the blood vessels to reduce the load on the heart
Preventing clot formation in the blood vessels
Reducing oxygen demand by decreasing heart rate and contraction
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