Very happy Vincent asked why it makes headlines when a few more poultry workers get infected, especially considering how low these numbers are. I admit whenever I'd read these headlines I'd feel impending doom, but Dr. Offit's answer was very reasonable, logical, practical, and comforting (as always). Bottom line: If you guys aren't worried, then I won't be worried. Thank you, gentlemen!
I appreciate Dr. Offit's moderate tone and desire to be measured and not sensational in his language. However, I'm struggling to reconcile two statements that he makes; his statement that H5N1 has not yet adapted to bind to alpha-2,6 sialic acids (@ 4:55 of this video) and his later acknowledgement that H5N1 influenza viruses isolated from cattle DO bind alpha-2,6 sialic acids (@ 6:40 of this video). While it is true that receptor-binding is likely insufficient to create the next pandemic virus, acknowledge that H5N1 actually is adapting to receptors in the mammalian upper airway seems to be at odds with the title of this video.
@@Fishevo The authors show that the virus replicates in mice and ferrets, but that is different than the receptor-binding assay. The receptor binding assay is an in vitro assay using immobilized sialoglycopolymers. That's the experiment Dr. Offit is referring to and the result shows that the bovine H5N1 isolate, similar to a human H1N1 IAV, binds to alpha-2,6 sialic acids, the receptor type present in the human airway. I suppose whether or not bovine H5N1 isolates replicate in primary human cells or cell lines is not shown in the UW-Madison paper. Though I suspect that experiment has to have been done by somebody.
And yet my Grandmother age 8 lost her mother in rural Wisconsin from H5 influenza in 1918...and now today July 15, 2024 it's up to five poultry workers in Colorado tested + H5N1 of double digits symptomatic. And it does bind to the sialic acid receptors they've found last week I thought? 🤔 But 'On Wisconsin', thanks for the mention.❤🧀
@@vin5388 There are other H's that will infect the respiratory tract. I'm old enough to remember the 1968 flu pandemic which was an H3N2 (just looked it up).
With everything else going on in the world these days, it is great to know that I can cross avian influenza off of my worry list. I view this channel as an authoritative source of information, so I will let the people I know who are worried about this nothing burger virus check this video out and stop listening to the mainstream media. Now, if only Dr. Offit could get the media to stop Yap yap yapping about the return of Covid.
As a layperson, I don't understand why a distinct bovine strain of H5N1, in the right circumstances, has infected humans. Do we humans become dead ends for the bovine strain? What could be the probability that the bovine strain will evolve within a human host to transmit between humans? Finland now offers H5N1 jabs to its agricultural workforce. It takes the precautionary approach (even though it has dropped its guard against SARS2 in terms of public health protection).
@@Headroomtalking Aye, that I've read. I've also read that only one US State bans the use of poultry waste within dairy cow diet. Neighbouring Canada, the UK and EU (among other countries and trading blocs) also ban the practice. The US knows the risks, but appears to be sleepwalking into risk of further bovine to human transfer of H5N1 that lets the virus evolve to pass between until human to human takes place. What testing is done in people who have contact with cattle fed derivatives of poultry waste? What mandates for PPE for those people under employment laws? Prevention of means for virus to make the jump is surely vital.
Maybe mRNA vaccination must use intradermic way,If intramuscular way did not avoid blood spread of liposomes with mRNA ? If liposomes with mRNA blood spread, theoretically can induce endothelium transfection and inflamation after
If intramuscular injection way will be used,must avoid intravesel inject by using aspirate before inject technique,and inoculation must be lent to avoid blood spread of liposomes with mRNA. After strict intramuscular injection injected muscle must not be contract some hours. If forearm is suport sustain like after shoulder trauma deltoid muscle did not contract.,and liposomes did not blood spread.
