I mean...I love Buffy, but the vampires she fights don't usually use weapons, especially not guns. She's dealt with people with guns before, sure, but those were human - Blade's reflexes make him much more dangerous with them, and I really don't think she has a chance here.
Have you seen the comics? Buffy has been able to dodge lightning, hold up the front of a train over her head, and also for some reason has the memories and knowledge of all the past Slayers before her, because she's the last of her kind or smth. Buffy usually gets downplayed because people only seen her from the show and she doesn't really look that impressive, but she's more deadly then one would seem. I mean she still dies to Blade but whatever