Can We Create Universal Blood? 

My Dad was a universal donor. During WWII he served in the U.S. Navy in the Pacific, and was often "asked" to donate. Sometimes more often than was good for him. He spent part of his duty years laying flat in his hammock, while his body recovered. But saved many lives.

I complained about the volume of the background music in the last video. In this video, the music is very well mixed and not distracting at all. Thank you very much!

Wow, this was actually insanely cool. I can't understand why the RU-vid algorithm isn't showing this to more people!

This channel and Real Engineering are two of my favorite notifications to see. I know for sure that the video will be interesting and informative. Thank y'all so much for your work.

Thank you for covering a statistic on people *not allowed* to donate blood. I fall into that group, and sometimes get frustrated when that info is left out. Thanks!

I love how you include the references in the description. Kudos to you, my friend

i effin love science

I'm really starting to consider studying blood now after watching this.

The comments are very scientific( which, in my experience is very rare). So, great job Real Science. You help advance Science.👍

I love the Real Science videos. They always make me feel excited for the future and give that humanity, fuck yeah! feeling.

I have O- blood, and I'm 17. I've been wanting to donate my blood for months now but covid has made that difficult 🥺

this channel needs more subscribers

8:13 - "2007" 10:30 - "Sixteen years later" ... So we'll have it sorted in 2023!

Next Step: Synthetic Blood.

0:50 dear lord that needle is big!

The snip sound you used for cleaving the sugar molecules is one of the most satisfying things I’ve ever heard.

Thank you so much, this channel has opened me up to so many topics that schools don't teach- and more importantly kept me curious and wondering. The animations and concise explanations make the concepts so easy to understand. Huge shout out to all the work you guys do. :)

After donating for years, I went to the city donor centre to donate and they said they hadn’t seen blood so enaemic and asked to take the blood, not for donation but for study. Apparently instead of round disc red cells, they had taken on the form of peanut 🥜. I did have Bowel Cancer but that was years later. Maybe a sign to look for in Cancer possibilities.

I'm only a little bit in, but this reminds me of what is refered to as Chimera. Depending on the part of the body some rare people have diffrent blood types. Its mostly only come up for child paternal/maternal tests and donation compatability; it is extremely rare. I think it happens due to absorbing a twin early on in conception.

Sadly, I had finally found out my blood type was o- as I was in the hospital dying of AML. I am now in remission. (Little over a year now) I would donate often if I could. I am grateful for those that gave me countless pints of blood and platelets.

The topics this channel covers are amazing. This is some sci-fi Utopian future stuff right here. It's impressive how this advancement was made possible, by simply the ability to crunch more data more efficiently, allowing for the discovery of what nature has already created. It wasn't some miraculously out-of-the-box epiphany that only someone with an extraordinary mind could have thought about, it was discerning through a greater amount of the data that is all around us.

you are amazing, this is incredibly detailed and informative than 90% of the other science channels on youtube

Thank you for the subtitles!

Why aren't they looking for enzymes to cleave the rh-antigen ? There seems to be so much O+ blood in population. All of that would be O- aka universal donor blood.

What an awesome video! I thought I was up on the blood supply chain, glad to be proven wrong. Also the segue from Universal Blood to the Logistics of Normandy was top notch! One of the best seen.

Love this channel glad I was able to find this channel, just wish you all uploaded once a week. Never change the narrator please :)

you need way more subscribers, you are soo good at teaching

Great content guys!

Harvesting blood to fuel war is some dystopian shit

Keep up the good work

Fascinating stuff. Thanks 😀

One of the best channel

I srsly love human ingenuity. Big shoutout for all the researchers on this planet. Thank you

this was very good. I feel uplifted.

Glad I am. the universal recipient blood type AB+. I donate plasma since ab+ is the universal donor for that.

I’m glad I watched this video before I make an appearance on a quiz show (which, in all honesty, I expect to occur approximately never). The statistic at around 2:52 that only approximately 7% of the population has universal donor O- blood is exponentially lower than I would have guessed. I’m O- and, to my best recollection, so are my three siblings and my folks and I’m sure there’s one or more cognitive biases that caused me to think O- blood is more prevalent than it actually is. Against this background, whereas I have for a long time thought that prohibitions against gay men donating blood were an archaic relic of the 1980s, the thought that an HIV- person who is on PrEP, who is tested quarterly for HIV and other STIs and who is fully vaccinated against “everything” (including Hepatitis A and B) seems utterly irresponsible (although not being a big fan of being jabbed, I suppose I personally benefit from this as I have a clear conscience about not donating).

Excellent video

Whe need to share this marvelous piece of information Pls RU-vid, make this channel more famous.

W0000h Yes, yes we can

I'm curious if a similar process can be done for plasma as well. There are situations where blood plasma is specifically needed but the red cells are not. Add-On Edit: After some investigation I now understand the info I was recalling was about antibody incompatibility between plasma groups; thus, not applicable to the surface protein cleaving methods covered in the video.

Wow that transition from blood supply logistics to D-Day logistics, bravo.

People need to get out and donate blood. From needle prick to a full pint (500ml) donation takes between 5-8 minutes and they give you cookies and juice afterwards. And you're saving lives. Shit, take some of my vital life's blood in exchange for some cookies and apple juice?! And it can save lives?! What do you have to lose?!??....except 500ml of blood....

awesome

This needs more views and likes!

Lovely video. It gives hope n inspiring

A blood type that would change depending on its surroundings? That would be cool Maybe nanobots could manipulate the blood like the bacteria

I love that the references go through sci-hub.

Good stuff ❤ this channel

I love this real science documentary, it makes a lot of sense, is facts as right now.

I can't believe the video has less than 100k views. This is so amazing. I plan to make a presentation on this topic, inspired by your video. I'll definitely cite this video and encourage people to come over to your channel.

In the end humanity finds a way to help soldiers fight war with medical breakthrough.Genius level.

It's so cool how scientist just look to nature and then use it to create cures or tools.

This is gonna be a bloody video

Damn cool Thank you

Some good news for a change, very nice, thanks!

Very informative. I just came upon this channel and I like it, so thumbs up and subscribed for me. Maybe I can see if there is any info on neuroscience since I'm currently studying and working on a project to allow such to work jointly with a form of technology that I am developing. If successful (in maybe 10 years) we'll see what happens 😉.

I was a typed O- at birth. When I was 16, I got pregnant. My mother was worried that the father's was positive and would need to get shots to protect my future children. The father and I were both tested. We both were positive. I was O+. He was A+. I've never understood how I went from O- to O+. I am a blood donor and give when I can . If I can't, it's due to my iron level being high enough.

I've heard somewhere there are more blood types than the a, b, an o. Mostly in remote locations. Could be a cool video to do as a follow up to this video if it were true.

I love this! This needs more views!

And you got the bombay blood type, hh-, where the h antigen is missing.

It's about time, we're in 2020 already

Amazing

u asked us to donate our blood for free, and yet at the same time u charge the patient with hefty hospital bills for every pint of blood bag that he/she receive.

After my problems I had with my second pregnancy the doctors told me I dont have a blood type. Just a bunch of letters and numbers. Very true

Brilliant

well done.

A special type of RH- is considered a golden blood and it can be transferred to anyone. But the problem is only 43 people have it

This is so entertaining

Remember, there are always costs and other effects (not side effects, silly term) that must be learned and dealt with.

Is there a technology today to "cultivate" O- blood in a culture medium just like how we produce monoclonal antibodies and enzymes like rTPA, alpha 1 antitrypsin, adenosine deaminase?

Awesome! I'm A+ and tried to donate many times but was refused due to the fact that I'm anemic and not universal donor like my mom. Once the pandemic is done I'll check again if my blood is still crap. I'm currently not leaving my house because I have a crappy immune system. Been hospitalized twice before, not looking for a 3rd stay.

"Unfortunate Organism" is my new DJ name.

Very interesting video, thanks! But please, can you also use SI units? For someone not from the USA, it's difficut to figure out how much a pint is :)

the problem with "synthetic bloods" is they tend to interfere with most blood tests. I have only once seen a sample of blood with a synthetic oxygen carrier in it and I couldn't reliably test it for a Full Blood Count as the numbers were all nonsense and the plasma was so dark that many other tests which rely on optical techniques like spectrophotometry couldn't be done either. For making all blood group O, that's fine but the next time I test the patient's blood I'm not going to be able to tell which group they are, so then they MUST have group O blood until their own group is clear again (because safety) which would massively increase the demand for group O. That makes it difficult to phase this in. Once you've started using it, it's all you can use.

Wow!

Vampires be like: "Sure, I mean you could create universal wine, but who would drink it?"

Can we do studies on bone marrow and somehow take donated bodies from science and see if we can find a way to farm blood creation from bone marrow....? That would be absolutely crazy.... Just these machines set up to farm blood out of bones from individuals carrying each type of blood type...

0:15 Does anyone knows how to get that sweet piano piece/song at the background or hows named?

Could they eventually culture and maintain O- bone marrow in a lab from stem cells to make blood c constantly?

I miss this channel

Good news about blood, man. Science working sh*t out! =D

What about turning Rh + blood into Rh -? You only spoke about turning A or B into O. Considering O Blood also has to be Rh - to be universal donor blood. Considering the Rh - blood types are a lot less common than the Rh + especially in A and O it would seem to be pretty important to do that too.

What about the Rh antigen? That seems to have been left out in the latter part of the video.

Wonder what blood type vampires prefer... this would be like real deal science, probably too real for this channel

The next step could be synthetic, cloned or bacteria-grown Rh-null blood

Yes, the marine worm has a blood stream that hold up more oxygen and is consider as an universal blood. A mouse who has its blood switch to marine worm blood shows to be healthy, no negative reaction. A blood like this would reduce fatigue and tiredness. For now, it is used to conserve an organ longer. French Video: ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-CbCrqGiZhCs.html There is another way we can change our blood type: pelvis donation. It's not instant though but the receiver will get the same blood type as the pelvis blood.

Another great episode. Here's a question though: Why is it so hard to directly supply oxygen and remove CO2 from the blood artificially? I've been wondering about that since start of the pandemic - It seems to be possible, but only through an invasive method that can't be used for more than a few days.

How does the conversion process work for people with AB blood type? Would it need both the enzymes that are used for A and B types to convert them in to type O?

I'm confused. Research started again in 2007 but hit a wall with the enzyme from the river bacteria being 30x less effective than that of the gut bacteria. Then at 10:30 the narrator says 'but then, 16 years later, scientists have become armed with new technology". So a few options here: 1. She meant 2016 2. She meant 6 years (2013) 3. She is from the future. (2007+16y being 2023, this dumpster fire of a year is still 2020) 4. I missed something In case of 3: When, and has it been solved yet in your time? Also, can you make a video on the science behind that please? :P Other than this, great video (as usual)!

This is huge.

I think you should rename this channel to Real Biology.

My question is why is that the question and not how close we are to having fully synthetic blood

When data hoarding and break neck computer speed produced wonders.

So we can't force a blood type to change at all then? Or is it the latter l, I'm a bit confused.

Thank you real science for this information, but as we kno everything is tied in money today so does anybody or real science can give any rough figure of the cost of the new converted blood if they can mass produce it ? Because now the process is efficient can we take a price point of known method of synthesizing the enzym and added it the current cost of blood ?

I make a whole circulatory system worth of blood every 3 months

This is making me feel bad for not donating in a while as an O- type

Ab+ blood, universal recipient boi.

While the above video is exciting and promising, we really need to make it legal to pay people for blood. We already have a robust system of testing and accountability for plasma donation, not allowing more than so much at a time, how many times and how far apart, etc. And if over-donation is the primary concern, it seems that the development of a test could determine if the person had enough blood volume to donate. At the very least, given Universal Donor blood type is needed for not only those who have this blood type, but also in emergency cases, a program paying for this blood type could be started. Selling blood could become a nice way to make a few extra $ for students, and those in need.

What about the Rh Factor?