Cardiac Output & Venous Return Curves | 7.08 CVS PHYSIOLOGY 

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Hello, thank you for your clear explanation. I just didn't catch why the MSP doesn't change when the TPR increase or decrease. Can you help me with that please?

Effect of inotropy on VR ??

Please make more vidoes on Usmle step 1

Hi ! I'm an Italian student, sorry for my English. I know that pressure in peripheral veins is about 7mmHg and the pressure in right atrium is, physiologically, near 2mmHg. So the Delta P, responsible of venous return, is about 5mmHg. I also know that the right atrial pressure that blocks the VR is 7mmHg, in fact: DeltaP= 7-7=0 When we have a decrease in TPR, we have an increased VR. Doesn't this increase mean as an increase of the Q variable in Poseuille Law ? The poseuille law is: Q=DeltaP/R. If Q increases, we will see an increase in Delta P (if the R remains the same). Shouldn't this increase of Delta P also increase the pressure in right atrium which can block the venous return ? For example: if 7mmHg in peripheral veins turns into 10mmHg, shouldn't the right atrial pressure that block the venous return be 10mmHg ? So why all the blue lines in the graph (13:23) start at the same point ? Thank you so much I hope you can understand what I said

Please please upload more videos on other chapters

We know that fluid overload should not be given to pts with cardiac failure... However if we use these graphs to find the results of fuid overload on pts with decreased cardiac function it seems that there is not that much of a difference in the cardiac output. Also i dont under why in some starling curves of heart failure there is a plateau while in others there is a downward depression of cardiac function towards the end. I mean if we were to use the curve with downward depression with these vascular curves it would all make perfect sense for fluid overload in heart failure.

Hey, i dont understand why cardiac output first increases when right atrium pressure increases. Can you help me out

What is the cause of the knee (flat portion) on the vascular function curve ? And if it’s because the veins collapse at negative right atrial pressure wouldn’t that render the venous return zero instead of a value near 7 liters/min ?

Hi! I have a question regarding the resistance, I don't understand why an increase in resistance would not cause a decrease in mean systemic filling pressure. If resistance is increased in the arterioles, that means that the amount of blood per min getting to the venous side of circulation would decrease right? You explained that this would decrease compliance of the veins so MSFP is maintained, but why would this then not work for, let's say the kidneys reabsorbed more water causing the blood volume to go up, then the veins could also increase their compliance right and maintain the same MSFP. or the opposite, you lose a lot of blood, so the veins then decrease compliance, and the MSFP is maintained.

Can you explain why MSP does not change when you vasodilate or vasoconstrict? Thank you

Thank you so much for the video. I have a question about TPR and venous return. If we constrict the arterioles, why does VR drop? It takes slower due to resistance but the volume shouldn't change right?

Very well presented. You must have spent a considerable amount of time to put it all together. Thank you! However, I would appreciate it if you could clarify one nagging question. At 14:25, increasing TPR or decreasing TPR leads to an increase or decrease in CO at the same RAP and MSP. That means the driving pressure is the same but outcome is opposite. How do you explain an increase in CO or a decrease in CO at the same driving pressure (MSP-RAP)? Thanks in advance.

A QUESTIONS, HAVE U THE BIBLIOGRAPHY???

Thank you so much for the video! I have a question though, how does TPR not affect the mean systemic pressure/right atrial pressure? the venous return is increased, meaning that the blood volume to the heart is increased, so why does the RAP remain the same?

You said after increasing TPR blood flows slowly to vein and blood flow decreases to right atrium. So why the msp doesn’t go down? By the way I really liked your explanation. .