It assumes the nebulizer will produce the same % of small droplets at the same condition and a homogenized solution will have the same concentration in those smaller droplets. So even if it only can take 5 % of the analyte in the small droplets to the detector as long as it's always 5% it will still be proportional to the quantity of analyte. You will need to run a set of known concentration calibration standards to find out the signal to concentration ratio.
@@zeusyanexactly. Like a lot of analytical detectors work. Good example is the yield of ionisation of mass spectrometers. Guess the ionisation yield of a GC-MS (Gas chromatography with quadrupole MS and EI electron impact ionisation. It's 0.1 %. And a GC-MS is already sensitive as heck.
