CNM AU8 for Multiple Sclerosis (Gold nanocrystals) Explained by Neurologist

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CNM-AU8 is an experimental pharmaceutical developed by Clene Nanotherapeutics. It is composed of clean-surfaced gold nanocrystals in pharmaceutical grade water believed to facilitate metabolic activity in the cell. This video explains CNM-AU8, early pre-clinical research, and the results of the VISIONARY-MS phase II trial.
Selected Sources:
ACTRIMS 2023: CNM-Au8 bound for Phase 3 testing after positive data: multiplesclero...
CNM-Au8 Lessens Vision Problems in RRMS Patients in Phase 2 Trial: multiplesclero...
31P-MRS Imaging to Assess the Effects of CNM-Au8 on Impaired Neuronal Redox State in Multiple Sclerosis. (REPAIR-MS): clinicaltrials...
A Multi-Center, Open-Label Long-Term Extension Study of CNM-Au8 In Patients With Stable Relapsing Multiple Sclerosis (VISIONMS-LTE): clinicaltrials...
“CNM-Au8 Phase 2 VISIONARY-MS Trial Results: invest.clene.c...
Clene Announces Updated VISIONARY-MS Phase 2 Trial Data Presented at 2023 ACTRIMS Forum Show CNM-Au8® Demonstrated Significant Improvements in Clinical Outcomes, Brain Structure, and Visual System: finance.yahoo....
Gold-plated Nanocrystals Could Help Fight Multiple Sclerosis: news.feinberg....
Nanocatalytic activity of clean-surfaced, faceted nanocrystalline gold enhances remyelination in animal models of multiple sclerosis: www.nature.com...
GOLD NANOCRYSTALS MAY BE EFFECTIVE AS ADJUNCTIVE MS THERAPY: www.physicians...
Study protocol of RESCUE-ALS: A Phase 2, r andomised, double-blind, placebo-controlled study in e arly s ymptomatic amyotrophic lateral sclerosis patients to assess bioenergetic c atalysis with CNM-A u 8 as a mechanism to slow diseas e progression: pubmed.ncbi.nl...
REPAIR-MS/REPAIR-PD poster: invest.clene.c...
Comment or ask questions below! I would be happy to answer!
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Check out my book “Resilience in the Face of Multiple Sclerosis” FREE on Amazon: amazon.com/dp/... It's about 5 people with MS who live incredible lives, the science and psychology of resilience, mindfulness, and ho’oponopono. Paperback priced to generate $0 royalty.
Dr. Brandon Beaber is a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system. He is a partner in the Southern California Permanente Medical Group and practices in Downey, California (South Los Angeles). He has several publications on MS epidemiology and has participated in clinical trials for MS therapeutics. You can follow him on twitter @Brandon_Beaber where he regularly posts about MS news and research.
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Music: INNER GRACE - Copyright 2018 Wilton Vought Source: Really Really Free Music Link: • Video T
he video material by Dr. Brandon Beaber is general educational material on health conditions and is not intended to be used by viewers to diagnose or treat any individual's medical condition. Specifically, this material is not a substitute for individualized diagnostic and treatment advice by a qualified medical/health practitioner, licensed in your jurisdiction, who has access to the relevant information available from diagnostic testing, medical interviews, and a physical examination. To the extent that Dr. Beaber endorses any lifestyle change, behavioral intervention, or supplements, the viewer should consult with a qualified healthcare professional to determine the safety and efficacy of the intervention in light of their individualized information.

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6 сен 2024

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Комментарии : 88

@msguidedbits9511 Год назад

I shared this trial in a blog when the trial was recruiting. Thank you for sharing the results, really interesting. (It was fun to write, because remyelination is the Holy Grail of MS research; and the fabled Holy Grail is made out of Gold. I made an Indian Jones reference. ) Will be very interesting to see how it fares in the Progressive MS trial. 😊

@karenh7466 Год назад

Could you share a link to this blog post please?

@yourbeamofsunshine 11 месяцев назад

I reversed paralysis using colloidal gold. I had no clue when I started taking it that it had any effects on MS. My left side had paralysis issues. My whole health is transformed.

@mballer 9 месяцев назад

Why did you think to use it? Was it long lasting? What kind of paralysis was it?

@msguidedbits9511 Год назад

Lol, love that line- “RU-vid analytics suggests my audience is 0 percent rats and 100 percent humans!” 🙌🏼😂

@DrBrandonBeaber Год назад

@timm8860 10 месяцев назад

But is that number statistically significant?

@AaronBosterMD Год назад

Excellent video!

@DrBrandonBeaber Год назад

Thanks 😊

@homeofficecooking333 Год назад

Wow! Thank you for the great content again! I get so excited every Wednesday to see what you are going to be looking at next 😁

@keeferification Год назад

Daaaam. Gonna bling out my MS.

@michaelriddick7116 Год назад

Woop woop! 😎 😂🤣😂🤣😂 Spinning rims next! :D

@DrBrandonBeaber Год назад

@stonz42 Год назад

Thanks for explaining this Dr. Beaber. I read about it recently in a newsletter and was hoping it could help repair some damage to the optic nerves. I'm hoping clemastine shows promise as well. I have significant vision loss in one eye, but partial optic atrophy in both due to prior optic neuritis. Uhthoff's makes my vision terrible on a regular basis, so my summer activities are unfortunately very limited. Any treatment that improves vision (even marginally) would be a big win.

@ScottMarc-RT1 Год назад

Fascinating video. Thank you. These studies feel like modern day alchemical wizardry. Kudos to the volunteers . I'm interested in the impact of diet on the process of energy production on the cellular level. I believe the Wahl's diet is based on this theory.

@user-bx9le3cp5k Год назад

Gold has always been a natural healer

@4inrev Год назад

Thank you for your work.

@DrBrandonBeaber Год назад

My pleasure!

@enajenaj6841 Год назад

Thanks for the video. How about a video on coming off DMT after 60 for stable patients. Would you recommend your patients to come off DMT if they are stable at 60 or what would be the criteria.

@DrBrandonBeaber Год назад

I briefly comment on this at 12:19 in this video: ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-ADnBu8bqHy4.html

@youandmeandmultiplescleros402 Год назад

Fascinating! I wonder if insurance would cover it.... 🤔

@DrBrandonBeaber Год назад

If it succeeds in 2 phase 3 trials and gets ema/fda approved, why not?

@roberture5903 Год назад

@@DrBrandonBeaber that would be great news. Sir and thank you for everything that you do

@freethinkeralways Год назад

@@DrBrandonBeaberBecause insurance companies r not healthcare companies. They r financial companies & gold is expensive! 😀

@emconnell3519 3 месяца назад

I sprayed coloidal gold on my sons feet when he was in a coma. He's got marburgs version of ms. He's doing really well 👌

@DrBrandonBeaber 3 месяца назад

I'm glad to hear he is doing well.

@freethinkeralways Год назад

Thank you! I prob will not invest yet but willing to try it. There s nothing for DMTs exc immunosuppressives.

@MysticalDreamFire Год назад

Very interesting Ty for sharing and explaining

@Umetastic Год назад

I was invited to this trial but they needed me to go to the hospital 6-8 hours every 2 weeks. Couldn't swing that with a full time job. Wish I could have though!

@SammyJo99 Год назад

Fantastic coverage pf this exciting therapy! , I've been wondering how CNM-Au8 Nanocrystalline Gold could have such great effects when EBV is still in place. So I looked and found this cell study that showed Nanocrystalline Gold does have an effect on EBV. What do you think? Effect of Metal Nanoparticles on EBV-Associated Cell Culture Authors A.V. Holovan, G.V. Baranova Journal Mikrobiolohichnyi Zhurnal Date Feb 17, 2023

@SReegs2023 2 месяца назад

Very good 👍

@ahmedfowad2122 Год назад

Thanks for the information. I do have concerns about effects of gold on kidneys. I hope these nano particles will not damage kidneys and won't cause proteinuria...

@elizabethrash7370 Год назад

Thank you for another great video. Any thoughts on the commercialized NAD+ tru niagen ? Thank you

@yumpiri Год назад

It's the NAD+ and increasing the energy efficiency in the brain in my opinion, not something exclusive to gold particles. Companies should focus on effects of NAD+, NADH, NMN, NR.

@jonathanplatts5825 Год назад

Question for Dr Brandon Beaber, have you heard of topical insulin eye drops? Insulin eye drop is an old treatment for repairing injury to the cornea and is sometime used ‘off licence’ for the treatment of eye ulcers. Recent research into treatments for glaucoma has shown that six weeks of Insulin eye drops can repair/restored damage to the optic eye caused by glaucoma. Insulin eye drops could be a potential treatment for damaged to the optic nerve caused by optic neuritis in MS. Insulin eye drops may also help to repair MS lesions at the front of the brain because Insulin is able to pass through the blood brain barrier. Love to see a future video on this topic to get your thoughts on this potential treatment.

@DrBrandonBeaber Год назад

I would be skeptical of insulin as a treatment of MS but if know of any published data on this, I would take a look.

@jonathanplatts5825 Год назад

@@DrBrandonBeaber The research into topical insulin eye drops is focused on damaged to the Optic Nerve caused by Glaucoma. The research has just moved into human trials following a successful mouse model of optic nerve transection, the research team showed that insulin administration after optic nerve injury promoted robust dendritic regrowth restoring vision after just 6 six weeks of administration. The teams research validates insulin as a powerful medication to restore dendritic function in glaucoma. I personally have suffered damaged to the Optic Nerve from Optic Neuritis caused by MS, therefore I am really interested to understand if insulin eye drops could potentially be a treatment for damage to the Optic Nerve and brain lesions behind the eye. The research I am referring to can be found here: classic.clinicaltrials.gov/ct2/show/NCT05206877 classic.clinicaltrials.gov/ct2/show/NCT04118920 www.medifind.com/articles/clinical-trial/217275467 There is a RU-vid video were one of the lead researchers discuses the findings of the animal trials stating that vision loss was restored after just six weeks of treatment.

@mballer 9 месяцев назад

Could this be overcoming excess sugar? Could lowering blood glucose do similar things I wonder. Thank you for posting the study.

@deaundrabrown3561 Год назад

Oh wow Interested information

@shadiothman4206 Год назад

Can you please comment on PONS therapy?

@cherylnavarrete4198 Год назад

My mom has Parkinson’s and I have PPMS and I have gotten a lot of similar symptoms she’s gotten 💁‍♀️

@Jerusalem_Warrior Год назад

Yeah, same here, poor dad, may he rest in peace.

@lindavanzwol2643 Год назад

An old lady in my street had MS, said she had coloidal gold, which did her good. She still walked and lived at her own home. She was between 70 and 80 😊. Just her living like that, gave me sooo much comfort. MS can be calm too.

@DrBrandonBeaber Год назад

Yes. Sometimes MS can be surprisingly benign as explained here: ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-t4tvdSwNE3k.html

@melissamcdonald5962 Год назад

Thank you for the video, Dr. Beaber! I have a video suggestion for you, I recently came across UCLA’s research that the hormone estriol given to mice with the mouse equivalent of ms promoted myelin repair. Could you do an informational video about the possibility of using estriol to treat ms in women?

@DrBrandonBeaber Год назад

Thanks for the suggestion. I Know Dr. Barbara Geisser and her research on estriol, and I may do a video on it at some point. There is much more than just animal data.

@marybethcully5883 Год назад

Wow that was interesting…I am looking forward to seeing the second and third trial studies. Thanks for sharing!

@DrBrandonBeaber Год назад

I will do a follow up video when these studies are published.

@andrewreisinger6860 Год назад

I would love to be able to time travel 50-100 years in the future and see where MS research and drug therapies are. I think the most likely progress will be made in STOPPING EBV infection in the first place with a real vaccine (not the mRNA CRAP), and we prevent people from developing MS.

@mballer 9 месяцев назад

Any mention of what this does to the gut bacteria?

@SirAlford 6 месяцев назад

I wonder if Nano Gold would help with Wilson's Disease?

@user-ht1ye8en8o 6 месяцев назад

There are colloidal gold products on the market already, what makes this one different?

@harindersingh517 Год назад

Hello interesting methylene blue seems to do the same for the mitochondrial your view use in MS

@johnkirk8650 Год назад

I guess CNM-AU8 would be a ‘heavy’ treatment, since Au has a high molecular weight

@michaelriddick7116 Год назад

With the boost in ATP, could this be used as a PED? 🤔

@DrBrandonBeaber Год назад

Interesting question.

@dominicp134 Год назад

+ in stress with arrogant league of legends player who said so often i would be bad and unflexible is another problem, so im surrounded by a couple of problems, dont know how to motivate atm

@DrBrandonBeaber Год назад

@CONTROVERSYRISING Год назад

Colloidal silver will do the same thing, quite easy to make

@joelt889 4 месяца назад

Dr. Beaber, do you think this would help my optic neuritis?

@DrBrandonBeaber 4 месяца назад

Possibly. I am working on an update to this video. The VISIONARY trial extension phase looked at ocular computed tomography and low contrast visual acuity which are relevant to optic neuritis.

@quantumdecoherence1289 11 месяцев назад

Just reviewing their results thus far have been disappointing and investors have taken note. The ALS results have been weak at best and the MS ongoing studies show very modest improvements in vision and not much with TFW25 tests or the composite as you nicely outlined here. If I were a betting man, I'd say this will go down in history like Biotin.

@harmcity9934 Год назад

you thought mavenclad was expensive... (drinkable golden diamonds for ms)>>>>>hold my beer

@DrBrandonBeaber Год назад

I think the amount of gold isn't that much. The 60mg dose would be 0.00212 ounces which is worth about $4 right now. Probably the cost of research, development, profit, and marketing would contribute much more to the cost.

@joerecto420 Год назад

Hi there Dr. Beaber, I really like your content; it's on point and very informative👏 🔥. Do you have a biz' mail and are you open for feedback? I just want to share my thoughts regarding on your videos if that's okay with you.

@hw7029 Год назад

A number of MS drug companies pivoted their studies during the covid pandemic to develop anti-covid drugs. They were chasing the bigger fish…but this meant a lot of existing investors abandoned them as they stopped developing what they promised.

@DrBrandonBeaber Год назад

Also it was hard to recruit people into clinical trials during the peak of covid.

@hw7029 Год назад

@@DrBrandonBeaber I’ve been watching the scale up/commercialisation of Redhill’s RHB-104 which is used to treat MS and Crohns. It’s basically combining a collection of off-patent antibiotics into a single medicine. It’s been frustrating seeing the MS study put on the back-burner whilst the organisation chases a covid therapy. For those in the know, the treatment is available right now by purchasing the individual antibiotics…but there’s not many specialists who know how to prescribe/manage this. This approach is explained well in the old Catalyst program “MS Cure?”…though there’s been developments in the approach since that program was aired.

@Zephas99 Год назад

Is this similar to Colloidal Gold?

@DrBrandonBeaber Год назад

I'm sure Clene would claim they are different but I am not an expert in the technicalities of nanoparticle production.

@Zephas99 Год назад

@@DrBrandonBeaber Thanks for the reply!🙂

@klburke Год назад

“A lot of these things don’t actually PAN out” lol get it, panning for gold…I’ll show myself out.

@DrBrandonBeaber Год назад

That's only funny in the UK. :)

@klburke Год назад

@@DrBrandonBeaber Well I'm Canadian, so that's probably why I also find it funny!

@debraindxb Год назад

So, with a father with Parkinson's and a daughter with MS, looks like we need to throw a couple of gold ingots in a Vitamix until this drug is approved...

@zoemcgonegal7734 Месяц назад

Micro - Greek letter mu - is one one millionth. Nano is one one billionth.

@DrBrandonBeaber Месяц назад

Thanks for the correction. I can't believe I missed that.

@zoemcgonegal7734 Месяц назад

@@DrBrandonBeaberI got one of the metric prefixes wrong on a test in an optics class. It turned out to be the difference between an A and an A minus in the class which then turned out to be the difference between magna cum laude and summa cum laude in my degree. LOL can't forget. 😅