Incase someone wanted a brief summary of functions, Functions of the following components: Collagen - Collagen has great tensile strength, and is the main component of fascia, cartilage, ligaments, tendons, bone and skin. Along with elastin and soft keratin, it is responsible for skin strength and elasticity, and its degradation leads to wrinkles that accompany aging. Proteoglycan - Provides hydration and swelling pressure to the tissue enabling it to withstand compressional forces. Lamina - Laminins also provide adjacent cells with a mechanical scaffold and biological information either directly by interacting with cell surface components. Fibronectin - Cellular fibronectin is assembled into the extracellular matrix, an insoluble network that separates and supports the organs and tissues of an organism. Fibronectin plays a crucial role in wound healing.
wow. you are amazing sir. you are moving at a very well pace and audible enough. everything you say is just so clear and simple. I need more of your videos.
There's some confusion here with what constitutes a GAG and a proteoglycan. GAGs (shown here as red lines) complex with core proteins (black line) to make proteoglycans (erroneous labeled here as a GAG). These proteoglycans can then complex with an HA backbone to make a superstructure. Also important to note that HA is in fact a GAG within itself, that is unique among the GAGs in that it does not complex with proteins directly to form a proteoglycan, but rather, serves as a foundation for other proteoglycans to be complexed with it via serine residues.
I thought the lamina are the intermediate filaments found in between chromosomes and the nuclear envelope and helps give the envelope structure. Then the laminin are the multi-adhesive matrix proteins that cause the cross linkage to collagens and Proteoglycans.
There are a number of different biological constructs called "lamina" - anything that forms a layer is basically a lamina. Laminin happens to be a lamina associated protein.
good efforts sir! you explain and draw very good ,only you should need to focus on arrangement and planning of your lecture ,you were forgetting some points of collagen and were adding it later on......otherwise you teach excellent !!!
