Computational Design in Grasshopper & Rhino3D. 

Thank you!

Yes, of course, you can learn how to do this with our Computational Design workshop at cademy.xyz/code

I am not sure if you can do something similar in Houdini. :(

houdini is a vfx software, specifically designed for movies/game development/content creation. Topology optimization is a branch of core mechanical engineering which is used to optimize engineering products and structures for weight savings, cost savings, and overall performance over the lifetime. there are multiple commercial packages available in the market which do the same for decades. if you only want it for the visuals, and your end goal is different, then you can simply create cad from scratch.