COVID-19 | Pathophysiology 

“When you take a breath in...” *takes deep breath automatically, oddly proud of my lungs for doing such a great job*

Thank you Doc for the wonderful lecture. Well, that explains why we as healthcare professionals should not sedate heavily or paralyze these COVID pts. Because when you sedate a vented patient, the blood pressure drops. And the traditional response is give more fluids. And the result is a viscous cycle of sedate, bp drops, then more fluids given and those fluids will go to the lungs. Thus needing more peep and oxygen requirements. As a respiratory therapist, we need to find the happy medium of ventilator settings and some sedation just to keep them comfortable. Thank you.

this guy explained it so well. haven't been this interested in a science lesson in a long time

Ngl I originally clicked because I thought you were shirtless in the thumbnail and I was intrigued by the thought of chaotic science man, but then I stayed for the engaging and informative presentation and overall I was absolutely not disappointed

Thanks so much for taking the time to post this. I have a layman interest in virology which is to say I don't have a medical background but to have viral interaction with body cells explained so clearly is really interesting especially in explaining why fluid in the lungs is generated and the mechanics behind that. I had no idea it was breakdown of the blood vessels and leaking plasma. Thank you, especially as I grew up hearing old folks in my Welsh village speak about fluid on the lungs and too much coughing leading to scaring. Until your post I didn't understand what was behind this.

One of the best COVID tutorials I've seen!

The simpler way you explain the pathophysiology is fantastic. Anybody can understand. Thank you.

Brilliant!!! I'm an RRT boning up on ARDS, and this is the most informative video i've found yet!

Pathophysiology: I learned a new word.

I was waiting for macrophages to come in earlier but the scenario didn’t go as I planned in my head! You’re explaining in such a great way that I remember the joy of studying when I was studying biology in university. Thank you :)

What does your fitness routine look like? You get a gold star for health good sir!

saving me minutes before my pathology exam

Hi Dr. Mike! Thank you, this is the best coronavirus video so far. I’ve been watching your videos for my A&P class, you make it so easy to understand. You helped me a lot 😀

Would you be kind enough to review how the virus in its relation to Cytokine Storm causes issues with coagulopathy? Thank you!

I love people like you sharing important information for free

It would help plenty to have links to research articles in the description or in the comment section, as references or for further reading

Amazing video. The audio could have been louder though😅

Incredible! Thank you for this explanation. You inspired me

he's so quirky and cute. like the awkward moment at the start and end where he just smiles lol

sir, that was mind-blowing. tomorrow i have an exam, and this helped me much♥️

A Big THANK YOU for making this video, it was asked in my VIVA examination.

Excellent. Thank you. Clear and concise.

Thanks for explaining it the way you did! Great video

Thanks Doc Mike.. wonderful lecture..Now I understand the concepts very well..You are a great teacher ☺️👍🏻

you explained it amazingly, thank you so much for all the effort, you are helping a lot of students.

Great explanation! Thanks from NZ

Excellent explanation as usual, but somehow you are very underrated

Hey! Just wanted to say I was watching your videos when I was reviewing for the licensure exams, and now i’m a registered medical lab scientist! So great to have watched this, as always, so easy to follow 😊

Awesome description, great understanding about pathophysiology of COVID 19

Realistically video, thank you so much, Doc

Thanks doc...great explanations

well done doctor💜

Superb presentation... well done

wow, your explanation on what surfactant does was really helpful, finally get it now thank you heaps

Thanks a lot, Doc!

Thanks for the video ! Ur a genius for simplifyiing medicine in sucha manner !

Outstanding presentation!

Awesome video, been trying to get my head around the whole coronavirus thing and watching this video really helped clear the gaps and understand it so much better. Great explanation cheers!

Great explanation. Cheers!

i took good notes and learned more about sars-cov-2 virus.thanks #stayhome #alertnotanxious

Amazing video. Appreciate the time and effort!

Thank you Doc, I t gave me a good understanding. I really appreciate you having done. I buried so many during the AIDS crisis and feeling like were are in the medical storm of a lifetime once again.

How would I cite this lecture? Is there a print version that approximates to this lecture?

Great Information Thanks

Amazing video !!thank you

Hey I have a question. During when the Spike proteins of the virus inhibit the ACE2 receptors, what will happen to Angiotensin I? Is it correct they are converted to Angiotensin II by ACE1 receptor. Since ACE1 has more activity it will cause more binding of Angiotensin II to type 1 Angiotensin II receptor and thus creating more pulmonary vascular permeability?

Nicely explained. but audio shoulde be more loud and clear!🎉

good and clear , easy to understand. thanks

Thanks Dr. Mike this video was really helpful. One thing that I didn't quite understand is, how does the virus inhibit the anti-inflammatory effects of AT 1-7? Does it use up the ACE2 proteins on the type 2 cells thereby reducing their availability or is their another mechanism I'm not understanding?

excellent!

Thanks doc! I just lost my step dad to covid on the 17th. It happened very suddenly. He started out delirious with a fever then two days later it went into his lungs and they inserted a ventilator. A day later they took it out and he died immediately. He was also a heavy drinker and had kidney failure and heart failure. We are heartbroken. He was only 61.

Thank you so much for your such elaborated video. It helps to clear my concepts.

Hey Dr. Mike and Dr Matt - Thanks ever so much for this detailed explanation of the pathophysiology of SARS-CoV-2 - My wife and I really enjoyed it! Nice one! In other news, my placement in ED was unfortunately cancelled (no more students in ED) - Totally makes sense from a risk mitigation perspective. I've been redeployed to the renal ward - Which of course is, AWESOME. The renal system is grouse! Your previous videos are helping heaps in this placement. Thanks mate. Take care!

Beautifully explained!

Very helpful.. Thank you so much!

Good explanation, thank you.

Thanks for the explanation. Its very helpful.

This is excellent information, not too technical for the lay-person (me), and very clearly explained. One thing I've not seen discussed, probably because no one knows, is the infectious dose necessary to start an an infection. My understanding is that different viruses vary widely in that regard. With HIV, for instance, I'm told that a huge dose is necessary, and that with norovirus, as few as a dozen individual viruses can be enough to start an infection and make you sick.

Thanku for this.....👏👏👏

Thank u for this

Great teaching!

amazing video really good explanation but the only thing I could focus on was his biceps and triceps :) XD

Thank you!

u are the best,sir

Very good. Thank you

this is sooo good! pls keep making videos 😊

Thank you. Your video is very helpful and it's also easy to understand.

Can you do a video on the microvascular thrombotic properties of COVID-19

Nicely explained. Thank you.

Very great video ! easily to understand and memorize!

Thank you so much

What happens when it goes through the digestive system?

this is excellent. Great job

I really understand the pathogenesis of the virus. Thanks very much.

Very nice lecture

Oh god , you are amazing 🤩 Keep uploading such lectures

You're amazing please make a video about dialysis hemo and peritoneal

Amazing expansion 😊

Excellent and very clear Dr

Very good, clear explanation.

Thank you Doc

Thank you

You really helped me through school last year and I see you are still doing amazing videos. Thank you..🙌🙌

We are armed with knowledge against the Corona Virus thanks to you.

Nicely explained..thanks

Thanks a lot from me in Germany! Very clear information.

Thank you very much👍👍👍

Thanx.. Very good

nice information but can you make a concept map of virus that how it links to varioussymptoms , risk factors , diagnosis and treatment please. waiting for this video

"So basically the patient is dying very fast for multiple reasons... I hope that helps!" *big smile XD Seriously though it was very informative.

Great lecture! Thank you!

perfect thank you

Nice presentation

great info mate...

Please make vedio about bone disorders like cervical spondylitis etc

Great info. So this is mainly droplet and not airborne? I work in a hospital and I feel like I can't get a straight answer.

Great summary!

What causes the sore throat ? Is it because the virus getting expelled out of the alveoli ??

It was very good presentation. Thanks for explaining so nicely. But you didn't explain the fecal oral transmission.

Thanks a lot, you make it so easy to understand. I don't even know much about medicine.