Simply put, the Cre/lox system rocks. It is one of the most powerful tools in the mouse geneticist’s toolbox. Why? Well, it enables them to generate tissue-specific and inducible knockouts and thereby have exquisite control over the location and timing of gene expression - important stuff when deleting a certain gene everywhere or during development leads to an embryonic lethal phenotype. And, it can be used to turn transgene expression on or off, track individual cells or cell lineages.
for more detail please watch video.
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26 сен 2024