Curtain Raiser 9 - Luteal Phase Defect (Part - 1) By Dr. Prof. (Col) Pankaj Talwar, VSM 

Curtain Raiser 9 - Luteal Phase Defect (Part - 1) By Dr. Prof. (Col) Pankaj Talwar, VSM
An interactive video lecture series: Curtain Raiser meant for IVF Doctors, Clinicians, Endocrinologists, Reproductive Medicine Specialists, Embryologists By IVF Specialist - Dr. Prof. (Col) Pankaj Talwar, VSM
𝐋𝐮𝐭𝐞𝐚𝐥 𝐏𝐡𝐚𝐬𝐞 𝐃𝐞𝐟𝐞𝐜𝐭
Welcome to our informative training video on Luteal Phase Defect. In this video, we will discuss the various aspects of Luteal Phase Defect, including its causes, symptoms, and treatments.
𝐖𝐡𝐚𝐭 𝐢𝐬 𝐋𝐮𝐭𝐞𝐚𝐥 𝐏𝐡𝐚𝐬𝐞 𝐃𝐞𝐟𝐞𝐜𝐭?
• The corpus luteum does not produce enough progesterone,
• It leads to an inadequate lining of the uterus
• Thus, it becomes difficult for a fertilized egg to implant.
𝐖𝐡𝐚𝐭 𝐚𝐫𝐞 𝐭𝐡𝐞 𝐜𝐚𝐮𝐬𝐞𝐬 𝐨𝐟 𝐋𝐮𝐭𝐞𝐚𝐥 𝐏𝐡𝐚𝐬𝐞 𝐃𝐞𝐟𝐞𝐜𝐭?
There are many possible causes of Luteal Phase Defect, including low levels of
• Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH),
• low levels of Estradiol, and low levels of serum Progesterone.
• Ovarian reserve, which refers to the number and quality of follicles in the ovaries, can also play a role in Luteal Phase Defect.
• Stress and hormonal imbalances
• Obesity and insulin resistance
• Endocrine disorders such as thyroid disease and polycystic ovary syndrome (PCOS)
• Uterine abnormalities and structural issues
• Chronic illness and medication use
𝐇𝐨𝐰 𝐭𝐨 𝐓𝐫𝐞𝐚𝐭 𝐭𝐡𝐞 𝐋𝐮𝐭𝐞𝐚𝐥 𝐃𝐞𝐟𝐞𝐜𝐭?
Luteal Phase Defect can be treated in several ways, depending on the underlying cause.
1. use of medications such as
• Clomiphene or Letrozole, which stimulate ovulation and increase the production of progesterone.
• Gonadotrophins, such as Oxydrogesterone, may also be used to increase progesterone levels.
2. In some cases, luteal phase support may be used, which involves the administration of Progesterone supplements to support the growth of the embryo.
3. Addressing any underlying conditions, such as thyroid disease or PCOS, can also help to improve the luteal phase defect.
4. Making lifestyle changes, such as managing stress levels and maintaining a healthy weight, can also improve fertility and the chances of conception.
𝐖𝐡𝐚𝐭 𝐚𝐫𝐞 𝐭𝐡𝐞 𝐌𝐚𝐣𝐨𝐫 𝐈𝐦𝐩𝐚𝐜𝐭𝐬 𝐨𝐟 𝐋𝐮𝐭𝐞𝐚𝐥 𝐏𝐡𝐚𝐬𝐞 𝐃𝐞𝐟𝐞𝐜𝐭𝐬?
It is important to note that Luteal Phase Defect can lead to infertility and difficulty in achieving pregnancy. It also leads to
• Increased risk of early pregnancy loss or miscarriage
• Reduced implantation rates for assisted reproductive techniques such as in vitro fertilization (IVF)
• Irregular menstrual cycles and menstrual flow abnormalities
• Delayed ovulation and reduced luteal phase length
• Decreased endometrial receptivity, which can affect embryo implantation and growth
• Higher risk of complications during pregnancy, such as preterm labor and preeclampsia.
Therefore, it is essential to seek medical attention if you suspect this condition
𝐖𝐡𝐚𝐭 𝐚𝐫𝐞 𝐭𝐡𝐞 𝐭𝐞𝐬𝐭𝐬 𝐭𝐨 𝐝𝐞𝐭𝐞𝐜𝐭 𝐋𝐮𝐭𝐞𝐚𝐥 𝐏𝐡𝐚𝐬𝐞 𝐃𝐞𝐟𝐞𝐜𝐭𝐬?
𝟏. 𝐏𝐫𝐨𝐠𝐞𝐬𝐭𝐞𝐫𝐨𝐧𝐞 𝐁𝐥𝐨𝐨𝐝 𝐓𝐞𝐬𝐭:
This test measures the levels of progesterone in the blood during the luteal phase of the menstrual cycle.
𝟐. 𝐄𝐧𝐝𝐨𝐦𝐞𝐭𝐫𝐢𝐚𝐥 𝐁𝐢𝐨𝐩𝐬𝐲:
This test involves taking a small sample of the lining of the uterus during the luteal phase to assess its thickness and the presence of abnormal cells.
𝟑. 𝐁𝐚𝐬𝐚𝐥 𝐁𝐨𝐝𝐲 𝐓𝐞𝐦𝐩𝐞𝐫𝐚𝐭𝐮𝐫𝐞 𝐂𝐡𝐚𝐫𝐭𝐢𝐧𝐠:
This test involves taking daily basal body temperature readings to identify patterns of ovulation and luteal phase defects.
𝟒. 𝐔𝐥𝐭𝐫𝐚𝐬𝐨𝐮𝐧𝐝 𝐒𝐜𝐚𝐧𝐬:
These scans can be used to assess the thickness of the endometrial lining and monitor the development of follicles and ovulation.
𝟓. 𝐇𝐨𝐫𝐦𝐨𝐧𝐚𝐥 𝐓𝐞𝐬𝐭𝐬:
Tests such as Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH), and Estradiol can be used to assess ovarian function and identify any abnormalities that may be contributing to Luteal Phase Defect.
𝟔. 𝐂𝐲𝐜𝐥𝐞 𝐌𝐨𝐧𝐢𝐭𝐨𝐫𝐢𝐧𝐠:
Regular monitoring of menstrual cycles, including ovulation and menstrual flow, can help to identify any irregularities or patterns that may be indicative of Luteal Phase Defect.
𝘿𝙤 𝙡𝙚𝙖𝙫𝙚 𝙮𝙤𝙪𝙧 𝙘𝙤𝙢𝙢𝙚𝙣𝙩𝙨 𝙝𝙤𝙬 𝙙𝙞𝙙 𝙮𝙤𝙪 𝙛𝙞𝙣𝙙 𝙩𝙝𝙚 𝙨𝙚𝙨𝙨𝙞𝙤𝙣 𝙖𝙣𝙙 𝙥𝙡𝙨 𝙛𝙚𝙚𝙡 𝙛𝙧𝙚𝙚 𝙩𝙤 𝙡𝙚𝙖𝙫𝙚 𝙮𝙤𝙪𝙧 𝙦𝙪𝙚𝙧𝙞𝙚𝙨 𝙧𝙚𝙡𝙖𝙩𝙚𝙙 𝙩𝙤 𝙩𝙝𝙚 𝙩𝙤𝙥𝙞𝙘.
You can watch the Part -2 of this Curtain Raiser - 9 here: • Curtain Raiser 9 - Lut...
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