My child was diagnosed six years ago and I’ve never seen anything with visuals that are this clear and with such succinct explanations. The CF clinics should use this for newly-diagnosed patients.
Incredible video, I really liked it. professionally speaking I'd only add a bit of information on the different types of protein mutation, meaning the different deformed protein channels that can arise. All the rest was just great!
wow, thank you :). I read half of two papers about CFTR and still didn't get how it's regulates water, because the paper was too in depth about signaling cascades and localization in apical membrane. I still didn't get how it regulates water. But, I just found the answer from this video, through osmosis and salt regulation. I'm too dumb to remember that aquaporin should exist everywhere in membrane and yeah, salt attracts water. And water can pass through this channel right?
Probably because they were forced to do this, lol I was, but I thoroughly enjoyed this and really appreciated the high quality images in it, so I'm not one of them!
Hello and good day.. I am Dr. Chaey Rellegue of DepEdTV Philippines. I would like to ask permission if we can utilize some contents of your video for educational purposes for our senior high school learners? Thanks and more power
Our materials are free to use for educational purposes. All videos and other resources are freely downloadable from our website: www.biointeractive.org/
I am suffering with severe cystic fibrosis, nasel polyps and lung infections.. I need the medicine that is made after research on this.. Can you provide me?
I’m so sorry you’re going through this. It all depends on your mutations, and you would need to discuss with a CF doctor. CFTR modulators is what they are called. The mental health side effects from the drugs were so bad we had to take our daughter off.
It is definitely on the short list of resources that will be translated to Spanish. I don't have a timeframe for when that will happen, but it is in the works.
Researchers tested over 200,000 small molecules to see if any of them would bind to the CFTR protein. Then for each small molecule that had some binding ability, researches chemical synthesized different variations of that molecule and tested them. They identified a drug that when taken by patients with a certain type of CFTR mutation, binds to the CFTR protein, opening the channel and allowing improved ion transfer. This increases chloride ion flow and maintains a watery, clear mucus, which helps the cilia move more freely and reduces the risk of bacterial infection.
