Avoid carbs is bullshit. The biggest example is that the longest living people on earth (living in the blue zones) eat many carbs. We have to distinguish between Refined sugar (which you should definitely avoid) and complex carbohydrates, that the body needs to digest, these carbs have low glycemic index. Many healthy foods like whole grains, legumes, fruits, and even vegetables have a big amount carbs, and to avoid carbs, we would have to avoid those foods, and essentially avoid important nutrients like vitamins, minerals, and disease-fighting phytochemicals. I highly recommend a video called: „Deconstructing the Paleo Diet“, that talk touches on the carb myth.
@@LeanAndMean44 Look at Asian population 50 years ago...Especially India they lived on so called low GI carbs... I think I don't have to elaborate more on that... Carbs are futile
@@LeanAndMean44 It’s a pity the science disagrees with you. Carbs are totally unnecessary and too much too often leads you to insulin resistance, which leads to metabolic disease.
@@snowflake5204 No, you shouldn’t elaborate from epidemiology. I just gave an example, but we shouldn’t elaborate from epidemiology - it just gives us a clue what to look at.
and he finished with a bang... "you've gotta take some risks, not everything will work, when they fail just keep going, you'll eventually get there if you focus on a dream" !
Interesting the comment on fasting. When I was a child I had quite severe asthma and eczema. The nail on my left hand index finger was buckled with a cakey something underneath it. My sister used to tease me... I'd never get married with those hands... lol.. kids. At age 11 I decided to fast once a week. Missed breakfast and lunch, just took a thermos with hot water with lemon and honey in it to school every Monday. Had a cabbage and carrot salad with a light lemon and oil dressing and then cooked non starchy vegetables around 4pm when I got home from school. By the end of the year I had no asthma or eczema and my fingernail had grown normal like the others.
How could you at this young age be so wiser? Fews people are awake enough to even see they have body to take care of, just leave it para some known dr out there.
I'm almost 69 and been following Dr. Sinclair's program for about a year, including taking a gram of NMN a day, and the results have been fantastic. I really do feel as though I am aging in reverse. I have more energy than I have ever had in my life.
@@ElonizuMuskamoto I get it from Amazon. But in my experience, I don't feel much effect unless I exercise. When I take NMN, the more I exercise, the more I want to exercise.
@@lourdesmartin6602 I searched on Amazon. A lot of brands were too expensive but the Livemax brand in multiple bottle packages came out to a dollar a day or less.
A fascinating book. Much of it way over my head but he explains everything well. Everyone should read Lifespan. I'm 78 so I can't stay young but maybe I can stay old a little longer.
one of secrets to living to 100 is proper food, toxic one gets stores in our bodies for years and years and eventually coming up and some for of diseases, natural food (and not all) can help you live longer. Feel free to read some articles about that - but be aware there's lot of noise in it - false theories etc. try to verify elsewhere everything you read about it
I really hope David achieves something great with his but imho what is really hopeful is the growing number of biotechnology companies investing in this field. If the science can continue showing it can be done there could be a huge acceleration of progress in the years to come.
Don't just be hopeful, Margics 🙂 because hope is not enough when action can be done: Donate in favor of the anti-aging research as much as you can, even just €1 per month like me (I'm still poor and I can't afford more). You can donate to the SENS Research Foundation here, for example: www.sens.org/get-involved/donate/
I thank "Talks at Google" for sharing all these novel talks worldwide instead of keeping these closed-door. Now I can sit in my study room and learn about some cutting-edge developments from the other side of the world. Thank you!
@@ogungou9 100%. I most definitely want to live a long healthy life plus I have a personal vendetta with diseases. Cancer killed my mom in her 40s. I know this is not directly about cancer but who knows where his researches will lead us. Preventions and Cures maybe.
This is how it sounds when an expert speaks. Unfortunately in society today we hide our experts under mountains of Grant proposals while we let the clowns with no practical competency to speak of run the world. Occasional breakthroughs of transcendent, species-level imperatives like this one (plus the institution known as Elon Musk) are exceptions defining the rule.
@@josephkellum2083 Yes. It’s a shame anyone will need to be “amazed” by a highly trained academic. There are lots of them out there but we’re in an anti-intellectual culture where dumbing down is the rule and intellect is often mocked and derided to make the intellectually lazy feel better about themselves. Watch out as this could result in a moron becoming president.
I love that naturally, I have seemingly gotten younger. My doctor recently said I have the physiology of a 17-year old and I am older than David Sinclair. I used to need glasses to read, but now I don't (no surgery or any other thing), my hair was thinner and now it's thicker. My sleep has gotten better in a huge way. I have more energy now than I did as a teen. I healed every issue that I had physically and emotionally. I have no pain, none of the pain I used to have. I am stronger as well. My changes were all about the inner guidance I receive. Thank you, David. This is a fascinating subject. I actually teach a class on age reversal so people look and feel more and more youthful, etc. Thank you!
@@almamunoz5276 None. It's all endogenous. I do take some vitamins but if I take them or not this happens because of natural things I do at home. Does that help?
@@ShroomGill I teach people true mastery over life, and I teach how to look and feel younger. I have 2 podcasts also and am an actress and a speaker, and have written 3 books. What do you do?
Check out his interviews from around 6-12 months ago, frown lines, nasty wrinkles that looked like a road map- Now, gone and he seemingly cannot move parts of his face...Stroke? No, BOTOX!
@@lyndenmanning8669 you are absolutely right. He looks like he's 50 or more. I just looked at his close up photos on google. He has so many wrinkles especially around his eyes.
For very different reasons, NAD+ has also attracted a wave of attention from cancer researchers. Recent studies suggest that cancer cells of many types depend on NAD+ to sustain their rapid growth and that cutting off the NAD+ supply could be an effective strategy for killing certain cancers. The data from these studies paint a more complicated picture of NAD+ and raise new questions about the diverse ways taking an NAD+-boosting supplement might influence health. “It might still slow down the aging part, but it might fuel the cancer part,” says Versha Banerji, a clinician-scientist at the University of Manitoba. “We just need to figure out more about the biology of both of those processes, to figure out how we can make people age well and also not get cancer.” This is just a fellow up to my previous post. Interesting that most sites are ignoring the possibilities of its effects on cancer.
As much backlash as he’s probably encountered, I pray that never stops what he’s trying to bring to light. If you ever need a nurse to help in research or testing, I give myself to this.
Quick your hired,run to Atlanta wearing no clothes in the middle of winter, packing meals not necessary and do it at night when you wont be exposed to the Sun and no cheating by stopping at any convenience stores to use their microwave,and when you get here will have a nice cold shower waiting and a bowl of hot soup of onions ,cabbage and carrots
I wish more people had your attitude Kelly. It amazes me that there are so many initiatives out there for every stupid thing under the sun but only a tiny fraction is put into age research.
We literally have nothing to lose trying to find elixir of youth, we may as well die trying. I myself am not really phased by dying. I dont wanna be old god damn it lol.
Just accepting ageing as inevitable seems blind. I am certain that there is at least one way to become immortal. Probably more than one way... Keep going Mr Sinclair.
@@MrManny075 If we were created by some kind of good force, then there should be a way for us to avoid all suffering to be fair. That would include watching yourself decay in the mirror by a process we call ageing.
@anders damin of course, ive been looking at all of this for like 5 years now. Aubrey says that they're doing basic research on how metabolism works and how to slow it down, he thinks that its a dead end that will eventually lead nowhere, since (acording to him) we cant tweak metabolism, and we have to treat damage directly. However, i hope sinclair and steve hovard are right about their epigenetics theory as the source of all damage. That would be a huge leap foward.
Aubrey actually says that metabolism is far too complex to be helpful to us now. Eventually, yes, we will crack metabolism, but it could be a century from now or whatever.
The fact that Calico has been at this for six years with huge funding and has produced absolutely nothing or has publicized nothing tells me everything I need to know. I hope I'm wrong though.
Don't keep this a secret folks. The best way to help Dr. Sinclair is to share the knowledge and get more people involved. Everything new needs a go through a period of acceptance from the establishment. The faster we get over the hump the better for everyone.
there are so many factors involved in anti aging. I try to do my best and tackle it from many angles. Im sure im doing a lot of things right because strangers comment ay how good my skin look and think Im younger than my biological age. The fact is you need a lot of money to cover all bases. first and foremost get rid of excess stress. no pill or drink will counter the effect of excess stress. the people in the most stressful jobs are the ones who age the fastest.
Fantastic! Thank you so much for devoting yourself to solving this important issue. If we can age without falling victim to dementia and disease, what a quantum leap that will be for mankind. May GOD guides you in your search for the answers.
Fabulous work David Sinclair. I hope the cure for glaucoma nerve damage comes while I am still alive as I have lost permanent vision in one of my eyes. My life has become different. I send you many blessings in your life and for your continued wonderful discoveries. Much love, Desiree.xx
I watched my mother shrink and not be able to walk more than a few yards without getting out of breath as she went into her late seventies. Now watching my parents in law fall apart slowly and get frail. Ageing sucks. It has made me determined to be one of the outliers that run marathons (slowly) in their nineties. Starting in my sixties and building muscle to go into old age with a good muscle base, sprinting twice a week, walking and swimming. Just started skipping meals until 11.30 am. Started NMN supplements two weeks ago and from the first day I can tell you it really works. My body runs warmer, my energy and mental clarity is much better, and after months of grinding slow weight loss, my diet is finally working and the pounds are dropping off. I am effortlessly faster on my runs. It’s crazy. Not sure I’ll take the Metformin/Berberine as I do so much exercise. Jury seems to be out on Resveratrol for similar reasons but the NMN is effective and does not block the effects of exercise. I think most of us who start it find you have to be older to feel it as your NAD levels are fine until around 50.
Sinclair doesn’t think the jury is out on resveratrol. He takes 1 gm per day. I think the known research and safety profile are almost astounding. If I could take only 1 it would be resveratrol. But I take more than 1.
Be careful about losing too much weight. It's actually better going into 'old age' with a few extra pounds for much needed energy when your appetite begins to falter....and you eat less and less and less. 😇
Applicable and effective process of self-care is restorative for the circulation/optimal health /reverse signs of aging and auto-immune skin disorders- improves the quality of life. In my case, lifesaving. 1- Massage using oil, 2-bathe in warm water +1 third or less cup of borax, 3-massage using rough cloth, 4- stretch small area of skin, tweeze and scale using a variety of nail clippers, in spiral and arc motions guide the instruments around the freckles and moles and all lighter areas of skin, avoid direct contact with dark spots, the dark spots will fade, many will disappear. Scalp, neck, and face massage regularly. hand and wrists, feet and ankles require the same treatments, as you tweeze between the digits and remove all plaque of superficial dried skin, your circulation will improve. Inform yourself of the common and known triggers of auto-immune disorders/disease, which causes symptoms of early aging- swelling-which causes skin problems and arthritis, etc and impedes circulation, the cause of most problems. You will become very skilled as you feel and see the benefits. Amazing. Animals groom for survival,
11:53 The metaphore is mixed. The Genome is the underlying code, the Software. The Epigenome is the Operating System, that is the Base Code that interprets and actions the Software's instructions.
This is the most exciting talk I've heard in a long time... I hope more work gets done in this field. Most diseases are byproduct of aging and if you stop aging you stop those diseases too.
Actually you do have to age even if u take those shot like what David said that can reverse age by decades. He use a word ‘reset’ so it’s like u age and you reverse it so diseases will be created while aging, we can not stop aging but scientists are trying to reset it.
I don’t know if you’ve been keeping up on the research, but over the last three years since you commented, David and people like him have made huge progress
Now that I am a founder of a major IT company, I am looking for ways to live long and enjoy my soon to be incoming wealth. So here I am and am so happy to have found this very intelligent scientist working at Harvard explaining in simple terms what is involved in prolonging one's life in an enjoyable fashion. Yes, this man should be protected and encouraged to continue his research. I, for one, will be more than happy to contribute to this cause.
Buy a thousand copies of his book and give them to your well educated friends. This will trigger an avalanche of inquiry that will result in increased funding of Dr. Sinclair's very expensive research.😇
I was doing a lot of the stuff from the book before that and this January I've decided to decrease the meat intake (maybe half of what I usually consumed) and started supplementing NMN and K2. I don't know if I'll live longer, my Horvath clock tests will show that with time, but damn I feel so good that it's worth it even without a lifespan increase.
I DO! I WANT TO LIVE FOR 1000 YEARS OR MORE! Can you imagine all the amazing discoveries and achievements you normally wouldn't get to witness? I want to live long enough to see humanity create a Star Trek like society. Where people choose to do things because they want to, not because they have to. And I want to explore the universe in a star ship. That would be so amazing!
I am happy to find someone else who wants to live 1000 years! So many negative people hate this world, hate life, have given up on humanity, and look forward to some fantasized after life. I love this life and want to explore it, change the world for the better, and be alive for centuries!
For Sinclair's twin mouse, the first who came to my mind is Christopher Nolan, who is also roughly the same calendar age ...while looking more than a decade older.
Caloric restriction is something I've heard from Michio Kaku over 20 years ago when he was on Coast to Coast AM with Art Bell. I think this method of prolonging aging has obviously been studied and practiced for many decades, if not, centuries and millennia in the form of fasting.
I am missing some words about the "exogenous" epigenetics (Bruce Lipton)..he is only talking about the endogeneous epigenetics..and generally not mentioning a single word about effects from psychosocial factors to genome and whole organism..
I really find this topic very interesting. Dr. David Sinclair discusses and explains it very well that can be fully understood. Thanks for sharing us your knowledge.
David is a superb speaker and a really good molecular biologist who is working on some really important stuff which could change how we think about and treat aging.
He is a brilliant geneticist but not a medical ethicist and there is more to life than science and technology. Telling people they can just take their own lives when they have "had enough" is not going to satisfy anyone. Yes we need to save money on end of life care but there also needs to be a way out that doesn't disrupt the natural order of things.
@@Elayman1 "Natural order" is cancer & heart disease. You want that? I don't want this natural order of things and to die. But you want me to die. Funny you talk about ethics.
@@jibrankhalil4837 Cancer and heart disease are the opposite of natural. They are largely controllable with proper diet and lifestyle changes, in the case of heart disease nearly 100 percent and cancer more than 50 percent.
@@Elayman1 hahhaa, How the hell people die? People don't die of old age, but they die of some age-related diseases such as dementia or others. Dude, no matter how much you take care of yourself, you will eventually succumb to a disease in your 90's and beyond and will die because of it. You don't just die off peacefully in your sleep as they show it to you in movies. Chances are you will "naturally" enter a slow, deteriorating decline for the last twenty years of your life where you would experience cognitive & functional decline and would eventually die in agony & pain. Although the unnatural morphine they give you in palliative care would help your suffering a bit.
@@jibrankhalil4837 They can die of pneumonia, asthma, bronchitis, and emphysema, and unintentional injuries (accidents) etc. The leading causes of death are all preventable as they overwhelmingly involve tobacco, high blood pressure and being overweight. Look up the statistics if you don't believe me. The importance of Dr. Sinclair's drug development would be largely be to support quality of life declines such as Osteoporosis, arthritis, muscle weakness (frailty) vision and hearing loss, etc.
I agree that eating right, getting enough sleep, taking vitamin supplements, exercising and not abusing our bodies (avoiding toxic things like alcohol, smoking, drugs) and you will live longer!!!
When I talk about this kind of thing to friends, many say "well I wouldn't want to live forever", or "I don't want to live 500 years". My answer is simple, do you want to live until next week? Do you want to see the next walking dead episode or whatever? And they all say yes. So I explain whether it's now or 100, 500, 1000 years from now, it's always just living until tomorrow or next week.
But is that going to result in a more meaningful life for the average person ? Even if people had all the time in the world, they will never be able to do all the things they wanted to do, and even if they do it again and again is that going to result in a similar experience to the first time ? I don't think so. At some point the law of diminishing returns is going to kick in and you are going to end up with people looking to suicide to relieve themselves of unending boredom.
With the realization that death is a rarity and that you and the tree will likely always be there, I can imagine it is going to be hell on earth for a lot of people.
Thanks so much David, you are a great help to me and being healthy and for looking forward ⏩ to live healthier and longer. Congratulations for all the good works you have made.
Back in day, when I was a "starving student", I too noticed that I had more energy, and improved mental focus; eating less + moderate exercise, coincidental?
Nothing to do with food but more with ignorance and the strong hypnosis to the young consciousness. (hypnotized by this existence and wanting to be and play in it)
I started intermittent fasting 8 weeks ago (16:8) and it is awesome! I'm vegan (10 yrs), and even fasting for 16 hours (skip breakfast, and go for as long as possible before eating), I'm' not really hungry since vegetables don't create hunger spikes. I just feel light and focused when I don't eat. And then when I eat I can eat tons of veggies and easily keep my weight at low-normal. This is a keeper! So glad I discovered it.
Meat does not create hunger spike either. What seems to the deciding factor is how much carbohydrates a person eats. Most people that eat a lot of processed foods are eating wheat in abundance and this appears to be the driving force in insulin resistance.
@@bighands69 "Meat does not create hunger spike either." Back in the day when I ate meat, I distinctly remember waking up ravenous for food when I had a meat dinner the evening before. On a plant-based diet, I can easily skip breakfast and actually feel better for it, lighter, sharper, happier. And getting hungry is a slower process, too. I can easily go into the afternoon before I start eating. I started doing 16:8 intermittent fasting 8 weeks ago and it was a winner from day one. After seeing the latest research from the Stanford Medical School, Harvard ditto, and listening to retired plant-based general practitioner-doctors s who have applied it to themselves and their patients and followed the results over decades, my own food intake has become much more serious to me. I'm eternally grateful that so much information is now available to the public!
Awesome Talk. I love the idea of being able to reset an individual's physical body back to an operation of the previous 10 years. I've thought about this concept myself over the years and have tried to implement a solution via Low carb eating, raw vegetables, no sugar, daily low impact exercise, B vitamins, hydration and other supplements (natural & synthetic). I have always dreamed about telomere extension since I thought that was the primary solution to extending life but now after this talk and previous ones I've seen and heard from David Sinclair, I now see that there's far more going on in our cells that will lead to healthy longevity. I'll continue to follow his research so I can continue to have a good understanding of these exciting discoveries.
@@irumkhan3381 The list is extensive. You may have to narrow your question up a little, such as "what supplements do (I) take for longevity, or focus, or daily regiment."
The real problem with all of this research into the biochemistry of aging is that we are living in a world grossly contaminated with thousands of chemicals known to be harmful to human beings. With the dumping of human trash in the oceans and burying it in the ground, this toxic chemical contamination problem will only increase exponentially as the world population increases. Ask yourself this question: What happened to all the nuclear fallout that resulted from above ground nuclear testing on this planet from 1945 to 1963??😇
Very interesting. I am a layperson. "Cancer. The Emperor of all Maladies" (circa 2015) states that it is not known how 40% of cancers work or how to treat them. That's a huge number. Proactively, I feel it is my responsibility to give my body all the nutrients it needs as a preventative dynamic living within the big 40% unknown. I've been consuming a 40-ingredient smoothie for four years, all plant based, fruits, nuts, vegetables, seeds. Very expensive, time consuming and major clean up. But it kind of flies in the face of your research and fasting. I very physically active and can't imagine a go-together between resistance exercising and fasting. Just ordered your book. Than you again for picking up all the pieces and searching for answers.
I'm 42 and I feel as if I'm only just finding myself, but the physical signs of decay are already apparent in my body. It's mostly cosmetic, but even still it's your body doing something with itself that you can't control, and that's never a good thing. Human life as we know it is far too short, and 70-80 years or so just isn't enough for me. A couple of hundred years would be nice, but 500 would be even better. I'd even settle for a workaround. If I could grow a clone of myself then mature it for 20 years, then transfer my consciousness to it then that would be fine too. Do that every 60 years or so and bingo - immortality (sort of). It's not as if the Universe doesn't have the space. Infinity is pretty big.
I completely agree with you. However, the physical appearance ("cosmetic") is a very important component for psychological well-being, needless to lie. And in any case the appearance reflects the functionality, as always happens in biology. "Aging Looks Are Not Just a Matter of Aesthetics": www.leafscience.org/aging-more-than-aesthetics/
it's hard to believe that googlers and whoever else is reading comments here would up vote such stupidity. For starters - if you will be able to 'upload' your personality / mind to the brain of another person (which will never happen, it's just a weird pipe dream of fiction literature) - this action means that you have to 'wipe out' the mind of that 20 yrs old clone which is in other words equivalent to a CRIME OF MURDER. Think for a second- how that person (clone) would feel if he/she learns that their only purpose in life is being body double for some schmuck, who will wipe their mind / memory /soul, if you like- just to replace it with theirs, lol.. beyond ridiculous..
I did the NAD+ IV drip at age 39-40 about ten months ago and it was very powerful. My mental acuity increased, soreness in my muscles and joints decreased, inflammation decreased and I gained strength, flexibility and mild gains in agility. The process literally 'purified' my body (you can imagine what the purification was like ;) So yes, I am 40 when I look in the mirror but I don't feel it. I go every three months now. You can take the pills too, or the powder, both are sold on Amazon or you can order them from a naturopath who does NAD drips...they aren't as effective as the drips but they ARE effective. Ideally, you should purchase tablets that you can dissolve under the tongue, as that maximizes absorption into the bloodstream. I also do hot yoga and hit the gym. I'm probably as fit and strong as I've ever been. So 42 is nothing to fear these days, although it does take some serious contemplation and maybe a mid-life crisis to realize that. Another thing that is often neglected is the mind. We have piled on 20 years of adult shit, caution, bitterness, anxiety, neuroses etc. that we lacked when our minds were young. In a phrase, life has kicked our asses. Therefore, it is important to explore potential brain technologies to basically function as meditation on steroids, such as neurofeedback (I use NeurOptimal) to calm the chattering mind and remove layers of trauma. This device has the potential to make us feel psychologically younger when we were bulletproof while retaining the wisdom of experience. Many other devices are coming out or are already out. Ask me if you want to know more :)
Occupy Mars still good, it’s said to reverse the aging process so it’ll still work 😄 My big though on this topic tho is that people want to make money on everything... so longevity (maybe immortality even) could be priceless. And I just hope it won’t be the case so everyone can be equal (which sadly is rare on this planet).
@@Lottiya Well, they will hopefully make it affordable. I tell you one thing, don't listen to Prof. Sinclair about eating less meat. He didn't do a deep research on this study and it's turning out wrong. So plz eat your meat.
Occupy Mars I’m vegetarian since birth and vegan for like 4 years now soooo I won’t eat mean hah And you should definitely read more about benefits of plant based diet! There are a lot out there and I think it’s worth to check it out ⭐️
@@Lottiya I did check it out many times, all of these plant based studies are weak, biased and full of anecdotal evidence. I can't understand nutrition completely and to other 99% of people it's way over the head to get a grasp. I also like animals and feel bad, but that's why I buy meat at a local farm where animals at least live a good life. Please eat at least fish sometimes.
I have been saying this... longevity is our choice! If we want to sustain our health, we have to do something about it! This will start by knowing what supplies our body needs. Start by eating a balanced diet, quit vices, exercise regularly and take an NMN supplement. Mine is a 500mg per day, NMN by Vitruvin. I just knew all of this lifespan information through Dr. Sinclair's book. It says there's no point increasing lifespan without. The goal should be to live longer while staying young and healthy. Sinclair believes that in the foreseeable future, it's possible for humans to live beyond 120 or even 150, without the frailty, diseases and disability we now associate with old age. See your result and tell the same experience.
that was some eureka moments for all of us. but i would like to add that as an indian(hindu) we do a lot of fastings(the religious ones) a year in the festivals and i would always think that how god can be happy by making us starve, its really awesome to have science backing this tradition.
I am 68 and eat one meal a day, usually after 8pm, for most of my adult life and don't feel hungry also stopped drinking soda at 19 after a Mountain Dew binge for a few weeks one summer was making me feel ill same weight as I was at 20, no belly fat, some of the work I do daily is quite physical which takes care of my exercise have not been ill in going on 20 years, take no medications, not even an oral antibiotic in 45 years I am low sugar (dark brown sugar in coffee only) .. ZERO high-fructose corn syrup whole milk, butter, cheeses nearly every meal, about a dozen eggs a week, lot's of fatty beef, fish about once a week, and quality hot Italian sausage as a treat, Chicken thighs for 3-4 meals about every 2 weeks, rye bread .. lot's of Broccoli (with onion, butter and cheddar), beans, red onion, garlic, .. cumin and turmeric as spices
Amazing information. Thank you Dr. Sinclair for sharing your research. Wow. I am enjoying the aging process very much. At age 67 everything is working just fine so far. If I were a mouse in your lab, maybe I'd still be going strong at 100.
@lanamuir9352 how And why the fuck would you enjoy the aging process why would that be something you would openly express positive comments about aging Evetually having little to no mobility and looking like a wrinkled prune and hair falling out
How interesting a pursuit! His book is very appealing; what a brilliant man is Dr. Sinclair. This is one of the foremost concerns of mankind historically, although there is such a massive amount biological information related to this line of inquiry. We are fortunate to have such a brilliant young man in our culture.
I am in awwww of this man. I understand what he’s saying to a certain extent but there’s a part(a HUGE part) that I’ll never understand. He’s a PHD n still learning and trying to save us and I’m a mere nurse just trying to fight Stage VI cancer. I only dream of knowing what his mind knows. Hopefully I’m around to know what he’s trying to know for us.
Dear Professor Sinclair, dear scientist and esteemed man! Although your concept of fasting, which is not new, but has been here at least for two thousand years, is trustworthy, you never mention how to manage craving for food. How can I fast if my appetite craves for delicious meals and takes over mind?
Very interesting talk. My real life observations as to how lifestyle habits etc converge with some of the info. My old dad is 91 now and if it was not for type 2 diabetes he would still be very able and fit. The diabetes and all its derivatives ie, initially heart disease (quadruple bypass) then the weight gain and circulation issues was the key to his lack of health. Much of this was brought about by the high carb, low fat diet he spent the last half of his life on, thanks to the 80's and onwards flawed medical advice, even though he never overate as such but did eat far too much sugar, but that was ok because it was all low fat 😒. About 5 years ago the doctor told me that I was close to having diabetes and would have to go onto drugs for the rest of my life. I asked him if I could override it with diet and exercise to which he replied no, wont work. So 5 years later I have consistently lower HbA1c thanks to diet and exercise (and no drugs). More recently I have moved onto a 16:8 eating pattern and reduced calories to get the weight down further, next move will be to a more plant based diet.
May I ask how old you are now ? I am eating plant based already but I find impossible to do 18:6 at night I get horribly hungry and in the morning I am hungry as a lioness would be !
@@andrewmays3988 We need to get to the root of the problem for every problem. Sugar is not the culprit. Glucose is the basic fuel that drives our cells and our body’s activity and it is essential for life. The fundamental problem of diabetes is that the glucose is not able to pass from your bloodstream into your cells. Since your cells are not getting the fuel they need you experience fatigue. There is also increased urination as the body tries to get rid of the excess sugar in the blood. High levels of glucose in the blood can damage the heart, and the delicate blood vessels of the eyes, kidneys, and extremities. Insulin is a hormone produced in the pancreas. It acts like a key opening a door in the cell wall that allows the glucose to enter the cell and fuel the cell’s activities. If your pancreas is not producing insulin or if when the key goes in the lock the door does not open that results in high blood glucose levels. Insulin functions by attaching to a receptor on the cell’s surface, which signals the cell membrane to allow glucose to enter. However, if muscle cell fat, called intramyocellular lipid, accumulates inside the cell it interferes with insulin’s signalling process. It’s like if the lock on a door became gummed up with chewing gum then the door can’t open. Fortunately, a number of studies have shown that diet can clean out our biological cellular locks so that the insulin keys can start working again. Usually, tiny organelles called mitochondria are supposed to burn the fat stored in our cells. When people are on a high fat diet, fat builds up in the muscle cells but also it seems the number of mitochondria that burn up fat are reduced. Historically, this could have been advantageous in environments where fatty foods are hard to come by but in our current environment it is problematic. It has been shown that when people adopt a low fat diet the fat in their cells drops and their insulin resistance disappears.
The most beneficial of the whole talk: hunger. Fasting for 2 and 3 days in a row is not bad. Your body is forced to kill old cells and create new cells. This is fact. I practice fasting 1, 2, 3 days of fasting and only drink water at least once a week. At least once a week. A regular week I will fast 3 time at one fast-whole-day per fast. Other times I will fast 2 days in a row in that week up to 3 days. I've fasted up to 6 days, but it's very difficult only because of habits, not really from hunger, but the habit of reaching for that thing I love to eat. Cutting sugar is the MOST difficult for me. I can say that I have not had milk in about 10 years. I stopped drinking soda years ago, diet soda about 4 years now ( I fell for that diet food/drink trick which is lethal on the body's health ). I have only stopped eating meat about a year now. And besides sugar, cheese if also a hard habit to break. Sugar and cheese, my problem areas. Eating for fun and taste is the basis of all get-together's, all things fun, involves stuffing the face full of horrible chemically treated dead-food sold as "edible food".
Hello! It feels that you are describing me! 😊After reading the book Paul C. Bragg "The miracle of fasting", I was 19 at that time, but I was so impressed that I have made a decision to give it a try and to see how it actually works in reality. I started with 3 days fasting (that was a mistake, because I never done that in my life...) , I thought that I will faint a couple times, but I survived and then I tryed slowly to come back to the regular eating, it was really hard not to overeat. It's really a challenge. Right now I am 48 and I have decided to do a regular 36 hours fasting once a week and I feel great! I have so much energy and I don't feel hungry at all. Going for 3 days fasting the next week, will see how is going to work. The hardest part is the cold when your metabolism is slowing down. I am trying to be more active then, to walk more, I wish that I could work out, but it's not good while you are fasting. I can't do only with the water for the same reason, so I take a tea, green tea is good especially if you have headaches while fasting, but water is essential. I drink min 2 liters per day anyways, so while fasting is even more. Yes, cutting sugar is the hardest part, I don't use any white sugar while ago, but a honey or maple syrup is still on my list, otherwise I have no energy, my blood pressure becomes much lower while fasting, otherwise it's perfect. I don't use any coffee for 3 years now, it was hard, because it's usual to drink so much coffee at work here is Sweden and it's very strong coffee. It took around six month until I could walk away from a coffee shop without just enjoying the smell like an ex smoker who enjoys another person smoking beside. Now coffee beans smells horrible to me, like something burned and unpleasant. Cheese was another challenge of mine, before I got lactose intolerant 4 years ago I use to eat it every single day, maybe that's why... 🤔 I don't see another reason, once my body just said: okay, honey, enough is enough, your cheese intake in this life is just finished... 🙄😏 Otherwise I am quite good with my diet, trying to eat as much organic fruits and vegetables as I can. Beans and lentils are good meat replacement. I still need some fish (mostly wild salmon or herring ) as a protein and vit D provider, but meat intake I have limited very much lately, I still enjoy some turkey breast sometimes, but like only once a week or less often. I hope I am on a good path. I workout regularly for 10 years now, I love to move all the time. I think that I will be fine, I got good genes as well, my mom is 73, she still don't need glasses just while she is writing something, almost no grey hair whatsoever, amazing memory (I wish I would have that!) she is growing her own natural food in the village, moving a lot, excercising every day. My dad died a few years ago, but he also had a terrible diet, nobody could change his habits, not even my mom, may rest he in piece. 😟 I am trying my best here, I never smoked, never used any alcohol in my life, the last and most difficult one is to cut completely a drug called SUGAR. The longest time I survived without any sugar whatsoever was for 6 weeks... 😏 It was a hell, just because my daughter likes to bake sweets. 🍰🍮🍪 I felt much better though, it's nothing to compare, it really takes a lot of power of will, as an addiction is 10 times stronger than to cocain... 😒 If I can do it, so do you! Good luck and stay healthy people! 🍀
I don’t buy that crap... and it’s not that cells forget their functions as he puts it, it’s rather the cells become less robust as we age. I don’t buy his analog/digital analogy at all. And also think his resveratrol discovery is snake oil. The reason that wine is relatively good is not just because resveratrol, but many other ingredients including the alcohol. In my opinion even a small amount of alcohol daily is beneficial. But I agree with most other things he says or recommends including making your heart beat fast/intensive exercise for shorter periods (not overdo it) because that fools our bodies into thinking that it needs to maintain its vigor. Don’t forget our bodies think that everything we do, we do it for survival reasons and as such our bodies respond accordingly to help us survive, and in this case maintain our strength and youth so we can keep doing those push ups(our body thinks we are crawling to get out of a dangerous place we fell, or lift those weights(lift necessary supplies for later use/survival) or run very fast one mile (get away from a charging lion lol) . So it’s all about lying to our bodies and fooling it into thinking that oh no no no we are not getting old at all, we still need to maintain our youth. Same with intermittent fasting/ staying hungry. Our cells in the body think that we are being deprived of food and now it goes in overdrive to protect itself and make it as strong as possible so that we will be capable of going out there and secure a meal (hunt/kill that impala, or catch that fast swinging fish, or walk long distance to find those yummy fruits and seeds/nuts) . Think of as if we are the devil and our body is the angel, or our brain is the snake, and our body is Eve. Devil is smarter and keeps tricking the nice angel to do what it wants lol.
@@otherone1234 He knows about the whole subject more than you do, clearly. You're not more intelligent than he is. You don't have any discovery. You're not doing any of the work. You have a fraction of the education. Nobody cares if you "buy [this] crap" or not.
@@apocalypseap apparently you cared enough that you felt compelled to reply to my message? You don’t know me, so it seems you’re being presumptuous to the point of making yourself sound stupid. As for what the dude preaches, some I do myself (figured on my own not because of him) some of what he says is pure b/s. I do respect his dedication to the field though. The more the merrier. As a side note I do know some very dumb people with Harvard degrees though, in case you’re trying to insinuate that an Ivy League school equals intelligence. I’m pretty well schooled myself, but the more I read the less I learn, so I’m back to basics, intuition and instinct mixed with a good dose of common sense and that my friend will beat any and all of your schooling credentials. I’m not quite sure if you’re lacking all three of those ingredients but as sure as hell you’re missing something.
I think that slowing down ageing , not only helps the society economically, because of age care savings, but also , imagine what will happen with individuals like Tesla , or Einstein , if they would live longer, and their creativity will continue for 20 or 30 years .I think, people will get wiser, more discoveries will happen in all sciences and arts. Not only that ageing won,t be costly for the society, but a lot of seniors will be productive longer . I do not think that seniors have to be seen as a burden to society , but will give a boost, because will be more creative and productive in old age. Having wisdom, they will not party, and watch movies, and have love affairs, but will concentrate on working at discovering new things in science or produce more masterpieces in art. Now,,it is sad, when great minds have to stop their work because of old age , or death. The civilisation will advance quicker, if ageing will be delayed.
telomere shortening was correlated with aging, so people thought lengthening telomeres would reverse aging. However, now we know that telomere shortening cause changes in epigenetic makeup of the cell. So simply lengthening telomeres never reversed the epigenetic changes. What will happen is that epigenetic change reversal, telomere lengthening and gene therapy aimed at implanting mitochondrial proteins into the nuclear genome will allow doctors to reverse aging in patients. It is coming and will likely happen within the next 30 years. Imagine what you can do with a much longer lifetime and a young body. Space travel becomes much more feasible since the travelers can stay young on the extremely long space missions that would be required to travel to near star systems which are at a minimum about 4 light years away, and would take much longer to travel to using the space travel of today without an alcubierre drive
Also if we live longer and global warming can be fixed since we are not doing it for next next next gen. It will be more realistic problem for all even the old and the old will not have to be supported health care down and plus they can be productive. A win win win situation
@@vinster9165 At max Space-Shuttle speed (17,600 mph), it would take roughly 170,000 years to traverse the 4.37 light-years, or 26.22 trillion miles to Alpha Centauri B.
That is the crux of it all. No one wants to get older because of the disease that is inherently associated with it. If we were older and had a good quality of life, no one would care if they aged. If we all lived to over 100 as many of us are now, we would have to find another planet to emigrate to. The world is already too overpopulated and having so many people living to unheard of ages would make that even more unbearable. I doubt if this will get off the ground anyway. It would be suppressed like a lot of things because health care is such a huge business.
Search Morley Robbins to learn what nutrients are often depleted, but are necessary to make Mg-ATP, the true energy molecule of the cell. In addition, you will learn what depleted nutrient activates oxygen in the human body, and deactivates oxidants. Once you get those basics down, then investigate Dr. Barry Sears and his anti-inflammatory Zone Diet. Synthesize both anti-inflammatory diet. BTW, drugs deplete Mg at an astounding rate, and Mg is required to activate ATP! INORGANIC Metallic Iron Filings in Cereal Video -- ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-HGbwFtmJOi4.html ** Some will claim beans and spinach have iron in them, so adding iron filings to cereal is no problem. Where is the video pulling metallic iron filings from spinach and beans? They can't do it. The form matters more than the name -- don't be deceived! Organic iron in plants is usable while INORGANIC metallic iron filings are quite toxic and designated as a carcinogen (increasing cancer rates are NOT coming from Mars!). Iron behaving badly: iron as contributor to inflammatory and degenerative diseases -- bmcmedgenomics.biomedcentral.com/articles/10.1186/1755-8794-2-2 Summary of Rogue Iron Accumulation in the Human Body -- veritascontent.blob.core.windows.net/audio/YTC_Archive/ytc010719-MorleyRobbins.mp3 Morley Robbins - My Theory Of Everything -- ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-Iq94ROB5qEs.html Morley Robbins - Magnesium, Copper and Iron Synergy - August 11, 2020 -- ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-kYEGfE9DUJ4.html Understanding Copper Toxicity (same as iron overload): ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-QyV4TgXCGC0.html The Iron Toxic Calcium Shell -- coppertoxic.com/calcium-shell The role of insufficient copper in lipid synthesis and fatty-liver disease -- www.ncbi.nlm.nih.gov/pmc/articles/PMC5619695/
@@LeanAndMean44 It's kind of hard to stick to a healthy lifestyle as a pizza delivery driver. 90% of the food I eat is whatever I can snag at work to bring home for the next couple days, lol. I usually try to make it as healthy as I can though, thin crust with veggies and whatnot, but it's still pizza.
Well, Botox for his forehead lines, a youthful wardrobe style (jacket over a t-shirt) and a hairstyle that pulls his hair over his receding hairline will mimic a youthful appearance. Also, white collar individuals staying indoors will always look younger longer (facially) than those that work outdoors due to excessive sun exposure.
i have been watching Sinclair lectures/presentations since whole night and what i have come to the conclusion (Correct me if i am wrong). Control your appetite is the key and hes proving the point of what Islam teaches us to fast for 30 days and this way you can control over your hunger. Glad science have proved it right and legit and people are practicing it on weekly basis as here many people claim that they fast about 7 days and keep themselves away from food. Minimize Sugar, as Sugar is destroying and i have noticed SUGAR has created a lot of diseases in asia especially in Pakistan and India (White processed Sugar is excessively used here). More research is needed to use NMN, NR or NADS (Too early as clinical trails are ongoing as per sinclair claims). Skip a meal or two, i think its a good idea to do normal breakfast with caffeine and skip your lunch (You can eat few fruits in afternoon if you cant remain hungry). May everyone lives healthy. Regards from Pakistan :)
Excellent presentation of Dr. Sinclair on Longevity. Very interesting snd educational. I hope this kind of research will continue as I see it very beneficial ultimately to most of the people especially our old folks. I hope our President at the present time will try to be involved in this kind of project since it will also help in eradicating a lot of different sickness confronting different people eventually saving a lot of people lives and making a very strong nation. Thank you Dr. Sinclair on your contribution in the field of Longevity. More power to you. Lady Liberty
NMN is nicotinamide mononucloetide. The first word is niacin related vitamin B3. You can get this NMN over the counter NOW> You can also get the precursor nicotinamide riboside over the counter for less cost.
Here's how I live as healthy as possible within my budget (I'm far from rich). I eat moderately and stay away from processed foods and sugars. I eat many tiny meals throughout the day, then fast the last 6 hours before sleep (I try get a minimum of 7 hrs of sleep). I don't over-eat but I do consume junk food in very low amounts. I avoid food colors and preservatives. I take supplements that are quite inexpensive but very effective. My top supplements I take daily are: CA-AKG (Calcium alpha-ketoglutarate) get a time-released formula. Glycine (an amino acid). Taurine (another amino acid). TMG (Trimethylglycine, also called betaine anhydrous). NAC (N-Acetyl Cysteine). PC (phosphatidylcholine) sourced from sunflower lecithin (I don't use soy lecithin). And a simple low-dose multi-vitamin. I'm 52 and have incredible health and looks. I barely have any grey hair and still have lots of energy to get things done during my busy days.
