Development of a novel prognostic signature for colon cancer in the TOSCA trial 

Alberto Puccini, MD, IRCCS Humanitas Research Hospital, Milan, Italy, shares insights from the Phase III TOSCA trial (NCT00646607), which investigated the optimal duration of FOLFOX and CAPOX chemotherapies in patients with high-risk stage II/III colon cancer. The study involved a cohort comparing patients who experienced relapse with those who did not. Through post-treatment sample sequencing after 3 to 6 months, researchers identified a novel differentially expressed gene with significant prognostic value, indicating improved disease-free survival for patients with higher gene expression levels compared to those with lower levels. This interview took place during the 2024 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.
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