Are there any studies out there specific to dietary effects on medication metabolism, especiallyvsertraline and venlafaxine? I ask because if I eat a 'classical' balanced diet for more than 2 days, I may as well not be taking any meds at all, a condition which is exceedingly unpleasant for me and those around me. Look forward to your input, and thanks!!
I had a hectic week with a few deadlines 😢, sleep deprivation for a week the heat /hot days irritated me, i just want to be indoors with AC. I noticed that these combinations lead to my knees arthritis worse. I know the benefits of good night sleep but sometimes we can't control things inude which stressing us out and lead to insomnia. I was thinking about my 3 deadlines on Friday , i can't fall asleep for over 1 hour even though i was exhausted. All i had in mind were the things i needed to do by what time 😢
This study needs to be done again but add HFLS and HSLF. This will give way more information, comparing the 4 outcomes. I’m surprised they didn’t check all 4 at the same time.
An eye opening study. It's clear there is a causal link between sleep and diet. As you've also mentioned exposure to blue light in prior videos related to sleep, I 'd be curious to know what impact screen usage might have on any given cohort's sleep patterns in future sleep/diet studies.
Agreed. High fat... depending on the type of fat... can be good for a person. Whereas, a high sugar diet is not good. Also, 3 meals a day are not always necessary. I survive extremely well on 1 or 2 meals per day. Fasting is good for the body.
The problem with this study is that they changed more than one variable at a time. Was it the higher fat or the higher sugar? Or was it from having a higher protein intake (if you reduce fat and sugar, there is only protein left)? From this data, there is no way to tell. A lot of people have improved their health condition using a ketogenic diet, fasting that creates a ketogenic state, and caloric restriction overall, but this study sheds no light on whether these steps will affect the output of growth hormone as a result. Further, if the goal was to increase growth hormone, why did they not measure this in the study? or A1C? Without that data, tying these results to a positive impact on diabetes is speculative at best. Last, the Mifflin-StJeor formula is a more accurate estimation of an individual's BMR.
You forgot fiber, which when wrapped together in fruits and vegetables, do not count as typical refined carbohydrates. Sugar is a carbohydrate, apples are a carbohydrate category when talking macros. But nutrition isn't about macros. Apples > than sugar nutritionally. ALSO, Fat and carbs do not play well together, so obviously, while REFINED carbs is bad for you, and too much fat is not good for you, the combination of refined carbs and fat is a powder keg in the body. its a case of 1+1 does not equal 2, but much greater. We can inference that the combination damages the body much worse than either by itself. The inflammation is worse. I use a fitbit to track my personal data, I can see my numbers go crazy under certain conditions. If my ideal numbers are on low fat (not "no fat") whole plant based foods, they get worse if I consume meat, or more meat or fat, but if I eat dessert...especially over several days, my numbers skyrocket in the wrong direction. Especially if I'm eating things that are fried, like fried chicken, fish & chips, cheese burger w fries and gravy. So the question of whether it's higher fat or higher sugar is almost irrelevant. MOST of us eat high sugar AND high fat.
Yeah and then with short term studies using small populations where you narrow the parameters you can make anything look good etc. It's the long term epidemiological studies of the diets of billions where it becomes pretty obvious which is the healthiest diet and by far. Don't forget one could use a low oil low sodium 100 percent wholefood plant-based diet generally and fasting for ketosis. There are other matters on the table re: dietary choice: animal suffering, reducing/ reversing metabolic disease, preventing the spread of pathogens since acc. to the orthodox science 3/4s of infections are zoonotic in origin and not forgetting caring for the environment.
I started IF last year and decided to not eat dinner; snacking at night had pushed me to become pre-diabetic. Also, I have ADHD and have trouble starting sleep. Well, I did IF to improve my glucose, but, did not know it also helped me get sleepy fast.
More specifically, high fat / low carb / keto diet VS high carb diet. But they won't do that because that will discredit the SAD diet... So many times you see "Low Carb" diet still have 15% to 30% carbs eliminating ketone production... Making the whole "Low carb" claim BS
Another very good video. I like that even being a lay person l’m able to grasp all the basic information presented the first time around, and the finer points the second time.
I use my fitbit to track my sleep. I eat very healthy with my last meal happening around 5pm. Last night, I took some magnesium before bed because a friend suggested it, and I got about double the amount of deep sleep than usual.
Could you please tell me which form of magnesium you took? I bought a supposedly reputable brand which turned out to be mainly magnesium oxide, the cheapest form and apparently not easily assimilated or useful. Thanks!
@@cherylreid5768 I have being taking Magnesium Bisglycinate 200 mg (only one capsule) at 8 pm and that makes me sleep very well. The dose depends on the person's need and diet. If i take more than one capsule I might get diarrhea. Other persons might need more.
@@LoveAcrossAmerica Magnesium Oxide is good for constipation because it's not well absorbed. For sleep, Magnesium Glycinate is frequently recommended. Magnesium Citrate is somewhere in between: Fairly good absorption but pretty good for constipation as well.
I have to agree with many of the comments, that far more work needs to be done on the topic. That said, I do feel the studies accomplished what it set out to do. That is show a linkage between diet and quaility of sleep and vice versa. I would bet that the papers recognized this and ended with the disclaimer that further study is needed.
It would be interesting to differentiate between healthy / unhealthy fat and sugar diets. I'd be particularly interested in seeing what would happen with a healthy fat intake and high sugar vs low sugar diet.
@@richardfeuille1212 Well, I'm no doc or even an amateur dietitian / health food person. But, it is my understanding that one should limit the intake of saturated and trans fat. From anecdotal evidence, myself, I consider sugar a poison. Fats, even the ones considered "unhealthy" seem to be far less of a problem than eating too much sugar. But, I'd love to see some studies differentiating all of that because my opinion is worthless. All I know is when I stopped eating refined sugars, and starting eating almost nothing but ingredients, rather than processed foods, I lost a lot of weight.
@@wocket42 Lol. I've been through all this, and have come to the conclusion that we're all different and we need to find what works for us as individuals. My cholesterol tends to run high, especially on a keto diet, and I was able to cut it in half by ditching keto and reducing sat fats and dietary cholesterol, while adding two cans (~600 g) of legumes per day for the protein and fiber. Plus exercise. I eat nuts (omega 6) and fish (omega 3) together once per day, to help maintain a balance.
And a fourth (what’s called the athlete macro split high complex carbohydrates, (for lots of exercise) pretty high in the protein 2 grams per kilogram and low fat.)
The results look negligible What dietary factors INCREASE slow wave sleep significantly from low levels? A lot of focus on sleep hygeine but very little on actually increasing slow wave minutes specifically
So , I didn't really take home with me , anything from this rapid explanation of some studies. I expected clear recommandations what to eat and when to eat for a good night sleep.
I suspect carbs are the most important factor. I don't think healthy fats (i.e. keto diet) is as important of a factor. Would be interesting to see a study of keto vrs normal American diet on sleep patterns. Cutting sugar and excess refined carbs from diet is never a bad idea, imo.
Interesting studies! Certainly I think we need more studies to elucidate the mechanisms here, and to change the diet in a variety of single isocaloric macro swaps. Also need to consider meal timing (particularly late eating) as we know this impacts sleep quality, though I don't know about SWS in particular.
One of the downsides of having a career in the health field is at one time or another you are required to do overnight shifts. How can people who are required to alternate between day shift and night shift within the same week stay healthy? Caregivers are exhausted as they go on to promote health and wellness!
I do see flaws in this data, mostly in the many possible variables not included like overall health including exercise, DNA, individual propensities like bedtime, (I go to sleep at 12:30 - 1:00am) , screen time, physical geographical location, meal times, etc. For example , when I go to sleep, I have to eat a meal at 8:30, or I am too hungry to sleep, I go right to sleep and sleep 7 hours straight. Still, your study is compelling.
are telling me is the bros were right? Drink 1kg/protein per kg body mass before bed in either whey or mycosoyprotein isolate mixed in a lowish fat milk? (Nothing about that was put into this study) I wouldn’t say that dietary fat should be completely avoided, as it’s really important for the sexy time and getting your period, and stuff. Diabetes can be caused by pretty much all of the psychiatric meds.
This presentation was completely confusing and didn't do anything to show what kind of diets best increased N3 Stage of sleep. Just a wa s te of time to watch.
Yeah I’m part of this bad cycle 😂 I’ve always been the nocturnal type. I like to eat at night but that’s usually what kicks in my fight with the Devil or as my a doctor calls it… Sleep Paralysis. 😂
I sleep horribly. My diet is IF, low carb/no processed foods, I'm a meat, veggie & healthy fat eater. Once an avid exerciser I only do some walking now. Just had labs done 2 weeks ago: A1C is 5.2. Triglycerides 68. Insulin resistsnce score is 3 ( less than 33 being insulin sensitive.)
Do you use any supplements? If not I recommend Magnesium (glycinate or threonate is best), apigenin, L-Theanine, and Glycine. Some others include glycine, myo-inositol, and GABA but I think it’s not recommended to use every night.
Are you a woman and around menopause? It seems we have trouble sleeping at this period in our life. Go watch The Proof with Simon Hill, he has 2 episodes about menopause with an expert on menopause if you need more info about this.
5:00 One problem with this setup, high fat high sugar, they should add a "high fat low sugar" and a "low fat high sugar" group. I'm very sugar sensitive since I was a child so I gradually gave up almost all sugar intake. I read some of those studies and find out that they always like to put high fat and high sugar together. And this is not how I eat for over 20 years. I eat high fat low sugar or zero sugar, not even with artificial sweeteners. I start to eat high fat low sugar since around age 18, and I'm always lean. I'm on my way to 40 now, I start to eat less carbohydrates and more protein.
the metabolism of carbohydrates involves an increase in adrenalin proportional to the glycemic index of the carbs that are consumed. this is why obesity experts restrict carbs late in the day. no new information.
They should have done high fat low sugar. This is the proper way to eat. Carnivore diet, etc... The lower score in the high fat high sugar group isn't because of the fat. It's because of the combination of high sugar along side the high fat. Fat wasn't the culprit, sugar (carbs) are.
How about not lumping high fat and high sugar in the same group because many people are opting for a low-carb high-fat ketogenic or even a carnivore diet end this study obviously does not include them .
Those plots show no change. The Medians touch on most plots. All you see is the noise comming from the limited number of samples. I have the impression you do not understand box plots. As you circle an outlier and say "show statistically significant difference". Quite sad to be honest.
@@Medcram I would want to look at the individuals who hit each end of the box plots and figure out what happened with them. Look at their blood. Did they monitor or ration water intake?
Thanks Dr. Seheult This video shows compelling data and conclusions, and sleep is so important. For the last 25 years or so, I have been using Niacin as B3 for sleep. I take 100mg of Nature's Way (B3) Nicotinic Acid before bed. If I open the capsule and put the powder in water to take, this speeds up the process. 10 minutes later, I experience a full-body flush, and use a rough cloth to gently massage skin where it itches. I am tempted however do not press hard on my skin. When the flush stops, I feel cool and tired, and quickly go to sleep.
I'd love to see a similar study that includes intermittent fasting free of this three square meals/day with healthy snacks in between, 2500 calorie/day dogma. Nutrient dense veggies/fruits, calories based upon season and level of activity. RDA with respect to calories is just too much as a one size fits all.
I think you would be able to draw better conclusions if they studied high fat/low carb vs High carb/low fat. It is silly to compare high carb/high fat against low carb/low fat. And it would have been even more interesting to test people in ketosis... I think you would find the saturated fat is a complete red herring... unless the study was funded by a pharmaceutical company in which case all the findings would really need to be thrown out.
@@Medcram But if you consider that there are three macronutrients. Protien is primarily for building muscles, bone and other structures. Fat and Carbohydrates are primarily used as fuel. So few people restrict both. The Mediterranean diet is not necessarily low in either fat nor carbs. On that diet you eat certain types of fats such as olive oil or fish fat. and you certainly eat plenty of grains, beans, starchy veg.
Why did they not do a high fat low sugar? They want to say high fat is similar to high sugar and blend t h e two together when they are really different. Thanks but this is wrong and animal fat is not unhealthy. Sugar is the killer here.
I can attest that eating has direct impact on sleep quality. I eat only meat, eggs, butter, salt, fish. I never slept better my entire life (56 years old). I fall asleep within 3-5 minutes usually around 11 PM and wake up fully rested and refreshed around 5:30 AM. Sleep is extremely deep and can last till 4 AM. If I have even small amount of carbohydrates, I have difficulty waking up. I feel tired for the better part of the morning. The sleep is affected for at least a week. If I have something that contains gluten, that period of disrupted sleep is extended up to 30 days. I prefer to eat meat for lunch. For dinner I will eat some eggs and little bit of meat. Once or twice I woke up around 1-2 AM after eating too much meat or raw eggs. This is a time when digestion kicks in. Butter plays major role. It is nature’s sleeping pill.
This seems to be a foolish study. Instead of differentiating between a high fat diet and a high carb diet, which is mostly the difference between a SAD diet, and a KETO/CARNIVORE diet, so a standard poor diet, and a much healthier version, they conflate a bad intake with a good intake, and then reduce both but presumably infill with veggies? Had they used high carb, low fat, or high fat low carb, I am pretty sure they would have got a more definitive result. Carbs, especially processed are terrible for you. Fats from meat are not.
Useless video bec it does not factor anything else like fighting with your wife or partner or parent, or if you have too much work or under a lot of stress or have an anxiety disorder, all of which would affect sleep and insulin resistance. No one person can isolate one thing in his life no matter how hard one tries to. Certain food items also have an impact on sleep quality (some cause many dreams etc), also nocturnal heartburn is another factor. As you can see, these studies are meaningless.
@@Medcram we understand but to single out one minute factor makes such studies too weak to be applicable. Besides, no one uses exclusively either of the diets studied
Five years ago I retired from a high stress job, supporting complex communications and IT equipment in a Fortune 100 electric company. I often described the job as "taking Computer Age skills to the end of Bronze Age roads at any time, in any weather." My cohorts and I were on call 24/7/365 and often got calls in the middle of the night. I recall a lightning strike that stretched an 8 hour day to 20 hours, with 4 hours of sleep before the start of a 16 hour day. We were all quite fit at the beginning of our time in the department; I was an avid cyclist who was chronically underweight. With the physical challenges and tower work we had to be in good shape. All that changed for every one of us during our time in the field. Those who had fewer callouts did fairly well; those who went out time and again faired worse. I wrote it off as the result of distraction: it is hard to maintain a physical fitness regimen on too little sleep and too little rest. Over the course of my 34 years I changed from being chronically underweight, and unable to gain weight regardless of diet, to chronically overweight and unable to lose weight until after I retired. This study makes me wonder if our sleep and rest habits are even more important than our dietary choices.
I've noticed for myself that a higher carb intake results in poorer sleep for me. Small meal, mostly vegetable, small amount of protein is the ticket for me
From my readings, I think that high fat low sugar diet is a much better alternative to either. I don't understand why nobody tried the high fat/low sugar/moderate protein alternative in this study.
I had problems with my sleep for years! What turned my life around was introducing L-Reuteri home made yogurts and other probiotics yogurts. Its incredible! Your gut microbiome may need resuscitation in order to help you sleep.
I do the 12 hr cycle, no eating outside that period. Not sure if its any better but add a day of light fasting did the trick. Thanks doc...never considered diet as part of sleep function other than no eating b4 sleep.
Lots of people are insulin resistant for many years without knowing it. Their fasting blood glucose tests come back normal so they think everything is ok. But they aren't and are shocked when diagnosed with type 2 diabetes. Doctors rarely do the kind of tests needed unless you go to functional medicine doc. Do a Kraft insulin assay to determine if you have hyperinsulinemia. (Kraft Prediabetes Profile - Meridian Valley Lab) Also, research has found that being exposed to any light at all while sleeping contributes to insulin resistance...which of course influences weight. The take away - sleep in pitch blackness. Get a red light if you must get up during the night to use the bathroom.
@@HidingFromFate Yes, blue light is daylight. You don't want to wake up too much in the middle of the night so if you need to get up use red light to see. It's not as disruptive so you can get back to sleep more easily. Some people wear blue blocking glasses in the evening so they can wind down several hours before bedtime. Also using dark screen mode on your phone/computer helps if you must use them....and just lowering the light all over your home in the evening. Being a night owl all of my life has not been good and I'm only recently learning about ways to improve my life and health. Circadian rhythm is such a power force that's It's best to be in tune with it. Our early ancestors were up at first light and retired when the sun set. Our bodies perform many repair processes to keep us healthy and these are done at night during the hours of darkness and, hopefully, restorative sleep. I'm only now learning about this and have decided to completely change my habits and see what happens. Good luck on your journey...whatever that may be.
The primary study used here was flawed to the point of being useless, but it is revealing regarding your understanding of the importance of fat in the diet. Both diet cohorts were unhealthful in different ways. Fat is good. Sugar is bad. Therefore, high-fat high-sugar has one good and one bad. Switching to low-fat low sugar also has one good and one bad. The only way to make that study useful would be to test sugar or fat independently, (or possibly test high-fat low-carb against low-fat high-carb), although this does demonstrate how easily people can be misled using "studies."
High sugar is clearly unhealthy. High fat not so. Combination of sugar and fat (Randle cycle elevation) is unhealthy. Pity the study didnt deal with sugar and fat separately.
Interesting study so I looked up the paper. I think there is a bit more to it than just macros. The main difference in the diets was dinner: the hfhs group got pizza and chocolate, while the lfls got salmon and vegetables. So I’d say the main difference is junk food vs very healthy food, on the meal before sleep. Pizza also includes high wheat exposure (both groups had some pasta for lunch).
Nothing wrong with wheat per se. The problem here was the pizza is made with refined flour. That’s not the same as having whole wheat berries in your salad or something like that.
0:27: 💤 The video discusses how diet and sleep can affect each other, creating a potential vicious cycle. 2:31: ⏰ Suppressed slow wave sleep can increase the risk of insulin resistance and diabetes. 4:41: 📚 The video discusses a crossover trial where participants were randomized to either a high fat high sugar diet or a low fat low sugar diet, and the effects of these diets on different phases of sleep were examined. 7:02: 📊 The study found that a high fat, high sugar diet led to an increase in slow wave sleep and duration of slow waves in N2 sleep. 9:24: 💤 Lack of sleep leads to increased hunger, food intake, and poor dietary choices. Recap by Tammy AI
The AI made a mistake. Mistakes happens from time to time with AI. The high fat high sugar diet negatively impacted sleep. Watch 7:05 to 7:11 when he summarizes the colored graph. The key information is there. It looks like the AI misunderstood the summary at 8:30 onwards. High fat high sugar diet reduced quality sleep on average. Best wishes. 🙂
I wonder what the effects are as it relates to Narcolepsy. I have N with cataplexy and have heightened symptoms with the consumption of carbs. However, I have noticed that fasting with eating at the end of the day helped me sleep for longer periods of time due to carb induced sleepiness. When paired with physical activity I saw a dramatic increase in my mood and restorative sleep feeling upon waking up.
Comments like this don't really make any sense when you have no idea when people wake up or go to bed. How does that work if you are on swing? A more appropriate way to put it would be compress your feeding time and don't eat a certain number of hours before bed. Like for me it would be six hours before bed I quit eating
This would have been much more useful if the fats and sugars were separated. Bad sleep raises morning blood sugars and therefore hunger, and morning blood sugars are more affected by sugar intake than fats. How would those cravings have been different with lower sugar intake?
Very good video! It would be interesting to look at it from the perspective of Long Covid treatment, as one of the main characteristic is the feeling of non refreshing sleep. Probably more than just a feeling, or we wouldn't be that tired. Also in perspective of its effects on the autonomic nervous system, which is also severely out of good working condition in LC. Thank you!
Incorporate exercise and wellness regimens into balanced diet, sleep will be good. Problem is most people not only drink alcohol, smoke substances or take various pharma-narcotics….this is extremely disruptive on the brain if not down right damaging……it’s that simple.
I admit this video does not fully make sense to me and maybe some of the information I would want is in the actual papers themselves. What bothers me is that there are different kinds of fats and sugars (or carbs if you will). Some fats are high quality, others are not. Some carbs are slow, some are not. I would have loved to have had a few more details in this video on that.
Thanks for this video and the others on sleep. After watching the one on beating jet lag (specifically the part about wearing sunglasses when the plane lights come on), I was thinking that avoiding sunglasses sometimes when outside might be something to try. I was taking melatonin every night at ~2am and have stopped doing that as I think it messed up my circadian rhythm.
I fasted for 5 days with fruit infused water and tea only. Nothing negative other than hunger pangs that were remedied with hot tea. At 67 years old, no arthritis pain, slept like a baby, sinus cleared up, face cleared, excema gone, more energy, more focused. So no food clearly helps to reset the body's system.
You are absolutely right! Although I was able to do a 4 day fasting I did notice the benefits on my brain function. I am doing fasting once a month 2--3 days depending on how I feel. I am having a hard time concentrating during a fast. Probably low blood sugar...
This study is flawed in so many ways. Small sample size is one. Being your own benchmark is another. What journal was this published in? Who reviewed the paper? Seems pretty weak.
I missed the change to 'professor'. Congratulations whenever that was! Not been watching so many recently although I'm definitely following the near infra-red light themed videos - a fascinating new field.
Very narrow. What about high fat, NO sugar, low carb? What about intermittent fasting? All this report does is try to push low fat diets. Ancil Keyes was full of crap.
The diet in the study has the high fat low sugar keto carnivore grouping excluded so has the group with perhaps the most benefit absent so it is interesting, but seems to include research funding bias that should have been rejected in it's ultimate format.
