DNA, Hot Pockets, & The Longest Word Ever: Crash Course Biology #11 

On a test: Question 14: What is the other name for Titin?

My biology exam: "Describe the processes of transcription and translation" Me: So hOtPoCkEtS...

God bless the editor who had to type that word for the video

"Hey what's your WiFi password?" "It's on the back of the router." *Back of the router: **0:01*

the protein at the bottom of the screen gives me anxiety.

me, a senior in a biomedical degree, needed some hank green to resimplify transcription and translation after my professor made it unbelievably complicated. thanks hank for making me feel sane

Has anyone ever thought about this? This guy teaches in 14 minutes what a teacher takes 2 weeks to explain...

all the comments from 5 years ago then there's me in 2020 tryna study this for my final tmrw

Hank talks pretty fast. So, I decided to play it at 0.5 speed to see how that goes. What resulted was the awesome discovery that Hank sounds totally hammered at half speed. Try it, you won't be disappointed.

And that was 2 weeks of school in 14 minutes. Boy, I do love crash course.

whoever took the time to write down that protein at the bottom of the screen - I commend you for the time and effort you put into that

Imagine how chaotically beautiful medicine would be if everyone had the naming sense of the dude who named Snurps and Spliceosome

Table of Contents: 1) Transcription 2:12 A) Transcription Unit 3:00 B) Promoter 3:10 C) TATA Box 3:32 D) RNA Polymerase 4:12 E) mRNA 4:15 F) Termination signal 5:21 G) 5' Cap & Poly-A Tail 5:34 2) RNA Splicing 6:08 A) SNuRPs & Spliceosome 6:26 B) Exons & Introns 6:56 3) Translation 7:28 A) mRNA & tRNA 8:01 B) Triplet Codons & Anticodons 8:39 4) Folding & Protein Structure 10:51 A) Primary Structure 11:11 B) Secondary Structure 11:23 C) Tertiary Structure 11:58 D) Quaternary Structure 12:44

"sorry for all the terminology" NO! For gods sake man, I have a midterm in two days. More terminology. Save us Obi-Hank, you're our only hope

poor scientist who had to write down the name of titin

God bless this guy. I don't think I'd be passing honors bio with out him 🙏🏼

Nobody: Poly-A tails be like: *_AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA_* Yes, there are 250 of them

Crash course makes A level biology much more understandable and fun!

Just wanted to point out two minor "mistakes" in the video at the 9 minute mark. 1. The first tRNA should be in the middle side of the ribosome ("site P"), THEN the second tRNA will go in the right side ("site A") 2. The ribosome should be the one "moving" during the animation, not the mRNA Anyway, awesome 14 min explanation!

Exactly, in 14 Minutes he's done more than I've learned in 14 days...

These videos are a part of my homeschool biology curriculum. Great work Hank! Also ham and cheese Hot Pockets are my favorite as well.

Have you ever wondered why the DNA contains thymine, while the RNA contains uracil? Here's an interesting fact. A spontaneous process called deamination (replacement of amino fuctional groups with keto groups) is fairly common in both DNA and RNA. As it happens, the product of deamination of cytosine is uracyl, and it is the most common of deamination processes affecting the DNA. The product of cytosine deamination (uracil) is readily recognized as foreign in DNA and is removed by a repair system. If DNA normally contained uracil, recognition of uracils resulting from deamination of cytosine would be more difficult and that would in the long run lead to a decrease in GC base pairs and an increase in AU base pairs in the DNA of all cells. Establishing thymine as one of the four bases in DNA may have been one of the crucial turning points in evolution, making the long-term storage of genetic information possible. (Source: Lehninger Principles of Biochemistry) Also, we commonly speak about introns as the junk which gets spliced leaving the ''important'' stuff for translation. Why do organisms have introns at all? It has been shown that introns are responsible for boosting expression levels of proteins up to 400(!) times (parts of DNA coding for introns include regulatory elements involved in transcription), they contribute to DNA packaging (chromatin formation), control the delay between gene activation and appearence of its protein product (which is especially important in developmental processes) and are responsible for alternative splicing. This latter process is extremely important because it allows one gene to produce multiple proteins, thereby increasing complexity of organisms without the need for occurrence of thousands of new genes. Also, many non-coding RNAs are actually products of spliced introns, such as miRNA, snoRNA, lncRNA, siRNA... (Source: www.ncbi.nlm.nih.gov/pmc/articles/PMC3325483/)

How do u eat DNA spaghetti ???? . . . . . . . . . . . . . With a replication fork

I saw a typo in the full word for titin. I demand for it to be fixed.

I'm studying for the AP Bio 2020 test on Monday the 18th, so the Crash Course intro is now my personal theme song XD Also, for anyone studying (or cramming) for the AP Exam: Things are different. Things are /hard/. We've struggled all year, clawing and biting our way through the piles and piles of knowledge that class has thrown at us. But this just proves how freakin' STRONG we are! Look at all we've come through! For what feels like forever, we sleep, eat, and breathe SCIENCE. And it's gonna pay off. I promise. WE CAN DO THIS!!!!!!!!!! On Monday, we're gonna put on our comfiest clothes, grab some coffee/tea, log onto that computer, and show this world just how awesome we are!!! You might be feeling a little powerless in the face of new changes - or even in the face of the all-too-familiar enemy of self-doubt. But once you realize that there's no punishment for failure and only reward for success - that's power. Once you realize how /prepared/ and /intelligent/ you are just for making it this far already, /that's/ power. You've got this. Trust yourself to do amazing on this, and I promise you, you'll come out on top.

there honestly needs to be teachers like you because teachers who cant teach but are there cause that the only job they can have need to stop.......

I will find that word and dedicate my life to memorizing it

This taught me, in 11 minutes, what an entire chapter in my entire textbook's failed to. Thanks for such an amazing content!

Hank Green is saving my Biology A Level one video at a time.

thank you for making biology relatable and understandable!!!

guys This entire thing is INSANE Don't you guys think this shit is MIND BLOWING? this shit is happening in EVERY SINGLE ONE OF YOUR CELLS How do they? Who.. Who told them to do this? WHy do they do this?? WHAT

Im convinced the editor just wrote random letters after the first 10 seconds

"All of those hydrogen bonds cause wrinkled sheets. UHUH!" XD Hank, that had me weak! 10/10.

Wow, great video. Only like ten percent of it stuck, possibly less but it's still a good video.

These videos are more helpful than any office hours session I've ever attended for any college science class -struggling nursing student

When he writes with the marker on the glass, he write backwards, doesn't he? drah eb tsum tahT

I would not have passed AP Biology without these videos

This video taught me more in 15 minutes than my biology teacher ever explains in a week. Basically this video alone got me a 90 on the test to thank you Hank!

LOVE Crash Course! You guys perfectly condense a really complex and complicated subject into like 15 minutes and present it in a way that is super easy to grasp. Y'all are my HEROES!

Macro-evolution truly is insane. The fact that a bunch of subatomic particles can create intelligence from only wanting to bind with each other. And then the intelligence is capable of seeing and studying these particles! Amazing.

"What are you going to name the Splice thing, professor?" "The... Ummm.... Uhhhh.... Splice... osome? Spliceosome???? I guess???"

I love the way he explains: easy and, at the same time, deep on the topic. Thank you very much for the classes. The edition and animations are GREAT too!

Today I had a lecture by a lecturer who studies proteins. When he asked us to give examples of proteins, I gave Titin as an example. He was like "OK...that's a protein, apparently." Longest protein in the world and he doesn't know about it, despite studying proteins...what?

who else has a final tomorrow and didn't study?

Easiest way to remember the START codon for translation: school starts in August "AUG". The movement along the ribosome, the "E" site: exit site, "P" site: polypeptide chain site, and "A" site is the amino acid site. I hope that helps with remembering some information during translation!

an 80000 letter word? ain't nobody got time for that...

they should have these vids be required watching in school

"YOU NEED TO KNOW IT" lol died laughing

thanks for helping me through 1st year bio x

Explained it better in 14(ish)minutes than my Bio teacher could in a week!

Hi Hank--my students and I love your videos. Have you every considered doing a short series on the discoveries that led up to these concepts, especially all of the molecular biology? I know some things, and have been able to research others, but would love to have it all collected in one place! Then I wouldn't so often be stumped by questions like "how do they know that DNA polymerase is the enzyme that connects the Okazaki fragements" and "how do they know ribosomes have 2 sub-units" and "how did they figure out which codon codes for which amino acid"? (you can see I have students that prefer not to take things on faith!!).

All the comments from 5-7 years ago and here I am in 2022 studying for my midterm thank you crash course

I really enjoy your videos. I went from a C in lecture to a B within a matter of a few weeks after finding Crash Course. Thank you Hank for being awesome and funny.

You just gave me more information in 14 minutes then my lecture teacher gives me in 5 hours and it was easier to understand... Thanks :)

A BIG THANK YOU FROM GERMANY! You really helped me getting through my exams with the funny and informative way of teaching these complexe topics! Without your videos studying really sucks... :)

college senior...still needs crash course xD

Hank is my new favorite person.

Thanks so much for these awesome videos! I get so bogged down in the details and these really help me to get back to the "big picture" :)

This is amazing, i'm mechanical engineer (not english native speaker) and i'm understanding everything in this series of videos; the nature is amazing, how through evolution it has created this enormous machinery that can store and use information to make and incredibly complex machine like multicelular living beings!

Rewatching these for studying :D though sadly I need to know more than what Hank has presented lol~ solid refresher tho ^^

I have a test tomorrow on this subject, you helped me very much!

This is what i am naming my first born child. Just to bother his teachers when they introduce him. ("This is..." *Five hours later...* "Say hello class!" Am I evil?

he is the reason I pass my biology tests. After j watch his videos I go through my notes again, and then they make sense. Also I have a good biology teacher but having it all compacted and visual is a blessing.

This video is so helpful!! I learned so much more in this video than I did in 2 biology classes- Thank you Hank!

I failed my test because I spent two hours looking up and creating a hot pocket rather than studying for my bio test....

I don't think that I can express my appreciation for these videos. Crash course biology is the only thing getting me through AP biology. Hank green, you are my hero.

Is no one going to talk about 2:34 - 2:38? lmao

College Biology Exam tomorrow. You just saved my grade!

I have a bio test over this tomorrow and I've missed so much school when we were learning it you're literally my life saver

I can not thank you enough for this, as well as your other videos. You make learning college biology fun and actually understandable!

Hank has a tick that I cannot unsee... he constantly bumps his glasses up on his nose with his finger.... 2:18

Hank, everyone i know at sixth form loves you, keep going buddy!

Why didn't I discover these videos sooner, I could have done better on my exams :(

Hank Green; better than a hot-pocket.

i hav a big bio test tomorrow. This video really helped me understand DNA to RNA to protein!!!

AP exam tomorrow. Here goes nothing

I can make the word go in whatever direction I want it to go, if I want it to go right, it goes right and vice versa. Try it and amaze yourself.

This channel is insanely good at getting the point across with minimal confusion. Hank speaks at 200% the speed of a teacher yet he is 1000% more understandable.

"Hank Green: Better than a Hot-Pocket"

When crash course gets you a better grade on finals than your acctual teacher 😩

You're the reason I made it through pre-ap biology with a 97% average, I'm forever thankful

Who else is watching this 20 minutes before their honors bio exam?

There was a typo in Titan... Good luck finding it :))

I watch this and the DNA replication crash course before every exam I've done this year... Incredibly helpful

"So grab a hot pocket" Me, sitting on the couch with a hot pocket: way ahead of ya buddo

This series has been pretty good for the most part. On this video though, gotta complain about Introns. They aren't just junk. We're still barely scratching the surface. The most notable is MicroRNA. But I guess as a general class setting, that little bit isn't that important to talk about yet.

Crash course helped me pass my psychology class in college, now I'm back for biology, so thank you for all that you do.

Having the word scrolled at the bottom of the screen is distracting...

My mom "What are you doing waching videos, you need to study for biolo... Oh you are. My bad" me:" L0L"

You make me love biology again by making things so simple to understand!! Thanks!! NOW I ain't afraid of molecular biology anymore!!

Hank is left-handed YES!!!!

Just in case anyone is doing homework (like me) and just wants to get to the point: Transcription begins at 2:53, and Translation begins at 7:58.... Your welcome.

7 years later and this still helps me with school … amazing! Your videos truly transcend time! Keep up the great work! Yes, Hank, I think we'd all agree that you are better than a hot pocket

Never had a hot pocket :( (Blasphemy, yes, I know.) Are they good?

ive been watching this video for hours LITERALLY!! Finally got a bit of it iN ma head ..phew thnx :P

The concepts make way more sense in college Biology than it did in Biology from Freshman year of high school. Very detailed and informative! Thank you!

You can change the direction of the words scrolling below just by thinking!!!!

O______O; Just mind blown is all... I couldn't help but try to imagine a computer acting like that, but that killed my brainz.

Thank you for helping me with biology. I have a biology class and you make it ten times as interesting. I have ADHD so it is really hard for me to concentrate but you make it super easy for me to concentrate. I really like these videos. They make it click in my weird brain. I am DEFINITELY going to recommend this video to people. And this channel. In fact, I already have. I also like it because I learn a lot of new words.

Rant: I *hate* the way that my college teaches biology. *Haaaate it*. I understand the concepts; I get it. What I don't get is this archaic lab book, its vaguely-worded questions, the dog-piling of mile-long assignments and stupid art projects that don't actually teach me anything other than how much this system sucks... GrrrrrrrrRRRRrrrrr. I've had a 4.0 throughout my entire college run; I'm not dumb. But this stupid, stupid class and the way that the entire thing is structured is abhorrent. How can we expect people to get into careers involving biology if it's being taught in a way that would make any sane person hate it to death?